Human Herpesvirus-6 and Human Herpesvirus-7

  • Paul H. Levine


Human herpesvirus type 6 (HHV-6) and human herpes-virus type 7 (HHV-7) are two of the most recently characterized viruses in the group that includes herpes simplex virus 1 (HHV-1), herpes simplex virus 2 (HHV-2), varicellazoster (HHV-3), Epstein—Barr virus (EBV) (HHV-4), cytomegalovirus (CMV) (HHV-5), and the Kaposi’s sarcoma-associated herpesvirus HHV-8.(33a,97a) The impact of HHV-6 and HHV-7 on the human population is largely unknown, although HHV-6 is generally accepted as the primary cause of roseola or exanthem subitum,(158,172) may be the most common pathogenic virus infecting infants and young children,(123,126) and also is etiologically linked to a number of illnesses (see Section 8.1).


Kawasaki Disease Chronic Fatigue Syndome Human Herpes Human Herpesvirus Viral Capsid Antigen 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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  1. 1.
    Ablashi, D. V, Josephs, S. F., Buchbinder, A., Hellman, K., Nakamura, S., Llana, T., Lusso, P., Kaplan, M., Dahlberg, J., Memon, S., Iman, F., Abalshi, K. L., Markham, R. D., Kramarsky, B., Krueger, G. R. E, Biberfeld, P, Wongstaal, E, Salahuddin, S.Z., And Gallo, R. C., Human B-lymphotropic virus (human herpes virus-6), J. Virol. Methods 21: 2948 (1988).CrossRefGoogle Scholar
  2. 2.
    Ablashi, D. V., Balachandran, N., Josephs, S. E, Hung, C. L., Krueger, G. R. E, Kramarsky, B., Salahuddin, S. Z., And Gallo, R. C., Genomic polymorphism, growth properties, and immunologic variations in human herpesvirus-6 isolates, Virology 184: 545–552 (1991).PubMedCrossRefGoogle Scholar
  3. 3.
    Ablashi, D. V., Salahuddin, S. Z., Josephs, S. F., Imam, E, Lusso, P., And Gallo, R. C., Hblv (or Hhv-6) in human cell lines (letter), Nature 329: 207 (1987).PubMedCrossRefGoogle Scholar
  4. 4.
    Ablashi, D. V., Agut, H., Bernemann, Z., Campadelli-Fiume, G., Carrigan, D., Ceccerini-Nelli, L, Chandran, B., Chou, S., Collandre, H., Cone, R., Dambaugh, T., Dewhurst, S., DilucA, D., FoA-ToMAsI, L., Fleckenstein, B., Frenkel, N., Gallo, R., Gompels, U., Hall, C., Jones, M., Lawrence, G., Martin, M., Montagnier, L., Neipel, F., Nicholas, J., Pellett, R. (Corresponding Author), Razzaque, A., Torrelli, G., Thompson, B., Salahuddin, S., Wyatt, L., And Yamanishi, K., Human herpesvirus-6 strain groups: A nomenclature, Arch. Virol. 129: 363–366 (1993).CrossRefGoogle Scholar
  5. 5.
    Agut, H., Puzzles concerning the pathogenicity of human herpesvirus 6, N. Engl. J. Mid. 329: 203–204 (1993).CrossRefGoogle Scholar
  6. 6.
    Agut, H., Huraux, J-M., Collandre, H., And Montagnier, L., Susceptibility of human herpes-virus 6 to acyclovir and ganciclovir, Lancet 2: 626 (1989).PubMedCrossRefGoogle Scholar
  7. 7.
    AmbindvR, R. F., Browning, R. J., Lorenzana, I., Leventhal, B. G., Cosenza, H., Mann, R. B., Macmahon, E. M. E., Medina, R., Cardona, V., Grufferman, S., Olshan, A., LE-Vin, A., Petersen, E. A., Blattner, W., And Levine, R H., Epstein-Barr virus and childhood Hodgkin’s disease in Honduras and the United States, Blood 81: 462–467 (1993).Google Scholar
  8. 8.
    Anagnostopoulos, I., Hummel, M., Korbjuhn, R, Papadaki, T., Anagnostou, D., And Stein, H., Epstein-Barr virus in Kikuchi-Fujimoto disease (letter), Lancet 341: 893 (1993).PubMedCrossRefGoogle Scholar
  9. 9.
    Ando, Y., KaiuMoTo, K., Ekuni, Y., And Ichijo, M., Hhv-6 infection during pregnancy and spontaneous abortion (letter), Lancet 1289 (1992).Google Scholar
  10. 10.
    Asano, Y., Yoshikawa, T., Kajita, Y., Ogura, R., Suga, S., Yazaki, T., Nakashima, T., Yamada, A., And Kurata, T., Fatal encephalitis/encephalopathy in primary human herpesvirus-6 infection, Arch. Dis. Child 67: 1484–1485 (1992).PubMedCrossRefGoogle Scholar
  11. 11.
    Asano, Y., Yoshikawa, T., Suga, S., Yazaki, T., KoNDo, K., And Yamanishi, K., Fatal fulminant hepatitis in an infant with human herpesvirus-6 infection (letter), Lancet 335: 862–863 (1990).PubMedCrossRefGoogle Scholar
  12. 12.
    Asano, Y., Yoshikawa, T., Suga, S., Yazaki, T., Hata, T., Nagai, T., Kajita, Y., Ozaki, T., And Yoshida, S., Viremia and neutralizing antibody response in infants with exanthem subitum, J. Pediatr. 114: 535–539 (1989).PubMedCrossRefGoogle Scholar
  13. 13.
    Aubin, J.-T., Collandre, H., Candotti, D., Ingrand, D., RouzloUX, C., Burgard, M., Richard, S., Huraux, J.-M., And Agut, H., Several groups among human herpesvirus 6 strains can be distinguished by Southern blotting and polymerase chain reaction, J. Clin. Microbiol. 29: 367–372 (1991).PubMedGoogle Scholar
  14. 14.
    Baboonian, C., Venables, P. J. W., Maini, R. N., Kangro, H. O., And Osman, H. K., Antibodies to human herpesvirus-6 in Sjogren’s syndrome, Arthritis Rheum. 33: 1749–1750 (1990).PubMedCrossRefGoogle Scholar
  15. 15.
    Barenberg, L. H., And Greenspan, L., Exanthema subitum (roseola infantum), Am. J. Dis. Child. 58: 983–993 (1939).Google Scholar
  16. 16.
    Berneman, Z. N., Ablashi, D. V., LI, G., Eger-Fletcher, M., Reitz, M. S., JR., Hung, C.-L., Brus, I., Komaroff, A. L., And Gallo, R. C., Human herpesvirus 7 is a T-lymphotropic virus and is related to but significantly different from herpesvirus 6 and human cytomegalovirus, Proc. Natl. Acad. Sci. Usa 89: 10552–10556 (1992).PubMedCrossRefGoogle Scholar
  17. 17.
    Berneman, Z. N., Gallo, R. C., Ablashi, D. V., Frenkel, N., Katsafanas, G., Kramarsky, B., And Brus, I., Human herpesvirus 7 (Hhv-7) strain JI independent confirmation of Hhv-7, J. Infect. Dis. 166: 690–691 (1992).PubMedCrossRefGoogle Scholar
  18. 18.
    Bertram, G., Dreiner, N., Krueger, G. R. F., Ablashi, D. V., And Salahuddin, S. Z., Serological correlation of Hhv-6 and Ebv infections in infectious mononucleosis, in: Epstein-Barr Virus and Human Disease (D. V. Ablashi, A. Faggioni, And G. R. F. Krueger, Eds.), pp. 361–367, Humana Press, Clifton, NJ, 1989.Google Scholar
  19. 19.
    Biberfeld, E, Petren, A.-L., Eklund, A., Lindemalm, C., Barkhem, T., Ekman, M., Ablashi, D., And Salahuddin, Z., Human herpesvirus-6 (Hhv-6, Hblv) in sarcoidosis and lymphoproliferative disorders, J. Virol. Methods 21: 49–59 (1988).PubMedCrossRefGoogle Scholar
  20. 20.
    Black, J. B., Inoue, N., Kite-Powell, K., Salahuddin, Z., And Pellett, P. E., Frequent isolation of human herpesvirus 7 from saliva, Virus Res. 29 (1): 91–98 (1993).PubMedCrossRefGoogle Scholar
  21. 21.
    Breese, B. B., JR., Roseola infantum (exanthem subitum), NY State J. Med. 41: 1854–1859 (1941).Google Scholar
  22. 22.
    Briggs, M., Fox, J., And Tedder, R. S., Age prevalence of antibody to human herpes virus-6, Lancet 1: 1058–1059 (1988).Google Scholar
  23. 23.
    Brown, N. A., Sumaya, C. V., Liu, C.-R., Ench, Y., Kovacs, A., Coronesi, M., And Kaplan, M. H., Fall in human herpesvirus-6 seropositivity with age, Lancet 2: 396 (1988).PubMedCrossRefGoogle Scholar
  24. 24.
    Buchwald, D., And Komaroff, A. L., Review of laboratory findings for patients with chronic fatigue syndrome, Rev. Infect. Dis. 13: S12 - S18 (1991).PubMedCrossRefGoogle Scholar
  25. 25.
    Buchwald, D., Cheney, P. R., Peterson, D. L., Henry, B., Wormsley, S. B., Geiger, A., Ablashi, D. V., Salahuddin, S. Z., Saxinger, C., Biddle, R., Kikinis, R., Jolesz, E A., Folks, T., Balachandran, N., Peter, J. B., Gallo, R. C., And Komaroff, A. L., A chronic illness characterized by fatigue, neurologic and immunologic disorders, and active human herpes-virus type 6 infection, Ann. Inter. Med. 116: 103–113 (1992).CrossRefGoogle Scholar
  26. 26.
    Buchwald, D., Hooton, T. M., And Ashley, R. L., Prevalence of herpesvirus, human T-lymphotropic virus type I, and treponemal infection in Southeast Asian refugees, J. Med. Virol. 38: 195–199 (1992).PubMedCrossRefGoogle Scholar
  27. 27.
    Burns, W. H., And Sanford, G. R., Susceptibility of human herpesvirus 6 to antivirals in vitro, J. Infect. Dis. 162: 634–637 (1990).PubMedCrossRefGoogle Scholar
  28. 28.
    Caligiuri, M., Murray, C., Buchwald, D., Levine, H., Cheney, P., Peterson, D., Komaroff, A. L., And Ritz, J., Phenotypic and functional deficiency of natural killer cells in patients with chronic fatigue syndrome, J. Immunol. 139: 3306–3313 (1987).PubMedGoogle Scholar
  29. 29.
    Carrigan, D. R., Human herpesvirus-6 and bone marrow transplantation, in: Human Herpesvirus-6: Epidemiology, Molecular Biology and Clinical Pathology. Perspectives in Medical Virology, Vol. 4 (D. V. Ablashi, G. R. E Krueger, And S. Z. Salahuddin, Eds.), pp. 281–301, Elsevier, Amsterdam, 1992.CrossRefGoogle Scholar
  30. 30.
    Carrigan, D. R., KNox, K. K., And Tapper, M. C., Suppression of human immunodeficiency virus type I replication by human herpesvirus-6, J. Infect. Dis. 162: 844–851 (1990).PubMedCrossRefGoogle Scholar
  31. 31.
    Carrigan, D. R., Drobyski, W. R., Russler, S. K., Tapper, M. A., KNox, K. K., And Asti, R. C., Interstitial pneumonitis associated with human herpesvirus-6 infection after marrow transplantation, Lancet 338: 147–149 (1991).PubMedCrossRefGoogle Scholar
  32. 32.
    Cermelli, C., Moroni, A., Pietrosemoli, P., Pecorari, M., And Portolani, M., IgG antibodies to human herpesvirus-6 (Hhv-6) in Italian people, Microbiologica 15: 57–63 (1992).PubMedGoogle Scholar
  33. 33.
    Chandran, B., Tirawatnapong, S., Pfeiffer, B., And Ablashi, D. V., Antigenic relationships among human herpesvirus-6 isolates, J. Med. Virol. 37: 247–254 (1992).PubMedCrossRefGoogle Scholar
  34. 33a.
    Chang, Y., Cesarman, E., Pessin, M. S., Lee, F., Culpepper, J., KNowLEs, D. M., And MooRE, R S., Identification of herpesvirus-like Dna sequences in Aids-associated Kaposi’s sarcoma, Science 266: 1865 (1994).PubMedCrossRefGoogle Scholar
  35. 34.
    Chen, M., Wang, H., Woodworth, C. D., Lusso, R, Berne-Man, Z., Kingman, D., Delgado, G., And Dipaola, J. A., Detection of human herpesvirus 6 and human papillomavirus 16 in cervical carcinoma, Am. J. Pathol. 145: 1509–1516 (1994).PubMedGoogle Scholar
  36. 35.
    Cherry, D., Roseola infantum (exanthem subitum), Textbook of Pediatric Infectious Diseases, 2nd ed. (R. D. Feign And J. D. Cherry, Eds.), pp. 1842–1845, Saunders, Philadelphia, 1987.Google Scholar
  37. 36.
    Clark, D. A., Alexander, E E., Mckinney, R A., Roberts, B. E., O’Brien, C., Jarrett, R. E, Cartwright, R. A., And Onions, D. E., The seroepidemiology of human herpesvirus-6 (Hhv-6) from a case-control study of leukaemia and lymphoma, Int. J. Cancer 45: 829–833 (1990).PubMedCrossRefGoogle Scholar
  38. 37.
    Clark, D. A., Freeland, J. M. L., Mackie, P. L. K., Jarrett, R. F., And Onions, D. E., Prevalence of antibody to human herpesvirus 7 by age, J. Infect. Dis. 168: 251–252 (1993).PubMedCrossRefGoogle Scholar
  39. 38.
    Clemens, H. H., Exanthem subitum (roseola infantum); Report of eighty cases, J. Pediatr. 26: 66–67 (1945).CrossRefGoogle Scholar
  40. 39.
    Coyle, R V., Briggs, M., Tedder, R. S., And Fox, J. D., Comparison of three immunoassays for the detection of antiHhv-6, J. Virol. Methods 38: 283–295 (1992).PubMedCrossRefGoogle Scholar
  41. 40.
    Cushing, H. B., An epidemic of roseola infantum, Can. Med. Assoc. J. 17: 905–906 (1927).PubMedGoogle Scholar
  42. 41.
    Declerck, L. S., Bourgeois, N., Krueger, G. R. E, And Stevens, W. J., Human herpesvirus-6 in Sjögren’s syndrome, in: Human Herpesvirus-6: Epidemiology, Molecular Biology and Clinical Pathology. Perspectives in Medical Virology, Vol. 4. (D. V. Ablashi, G. R. E, Krueger, And S. Z. Salahuddin, Eds.), pp. 303–315, Elsevier, Amsterdam, 1992.CrossRefGoogle Scholar
  43. 42.
    Dewhurst, S., Chandran, B., Mcintyre, K., Schnabel, K, And Hall, C. B., Phenotypic and genetic polymorphisms among human herpesvirus-6 isolates from North American infants, Virology 190: 490–493 (1992).PubMedCrossRefGoogle Scholar
  44. 43.
    Dewhurst, S., Mcintyre, K., Schnabel, K., And Hall, C. B., Human herpesvirus 6 (Hhv-6) variant B accounts for the majority of symptomatic primary Hhv-6 infections in a population of U.S. infants, J. Clin. Microbiol. 31 (2): 416–418 (1993).PubMedGoogle Scholar
  45. 44.
    DilucA, D., Mirandola, P., Secchiero, P., Cermelli, C., Aleotti, A., Bovenzi, P., Portolani, M., And Cassai, E., Characterization of human herpesvirus 6 strains isolated from patients with exanthem subitum with or without cutaneous rash (letter), J. Infect. Dis. 166: 689 (1992).CrossRefGoogle Scholar
  46. 45.
    Downing, R. G., Sewankambo, N., Serwadda, D., Honess, R., Crawford, D., Jarrett, R., And Griffin, B. E., Isolation of human lymphotropic herpesvirus from Uganda (letter), Lancet 2: 390 (1987).PubMedCrossRefGoogle Scholar
  47. 46.
    Drobyski, W. R., Dunne, W. M., BuRD, E. M., Knox, K. K., Ash, R. C., Horowitz, M. M., Flomenberg, N., And Carrigan, D. R., Human herpesvirus-6 (Hhv-6) infection in allogeneic bone marrow transplant recipients: Evidence of a marrow-suppressive role for Hhv-6 in vivo, J. Infect. Dis. 167: 735–739 (1993).PubMedCrossRefGoogle Scholar
  48. 47.
    Drobyski, W. R., KNox, K. K., Majewski, D., And Carrigan, D. R., Brief report: Fatal encephalitis due to variant B human herpesvirus-6 infection in a bone marrow transplant recipient, N. Engl. J. Med. 19: 1356–1360 (1994).CrossRefGoogle Scholar
  49. 48.
    Dreyer, Z. A. E., Dowell, B. L., Chen, H., Hawkins, E., And Mcclain, K. L., Infection-associated hemophagocytic syndrome, Am. J. Pediatr. Hematol. Oncol. 13: 476–481 (1991).PubMedCrossRefGoogle Scholar
  50. 49.
    Dubedat, S., And Kappagoda, N., Hepatitis due to human herpesvirus-6, Lancet 2: 1463–1464 (1989).PubMedCrossRefGoogle Scholar
  51. 50.
    Dunne, W. M., JR., And Demmler, G. J., Serological evidence for congenital transmission of human herpesvirus 6, Lancet 340: 121–122 (1992).PubMedGoogle Scholar
  52. 51.
    Eizuru, Y., Minematu, T., Mwamishima, Y., Kikuchi, M., Yamanishi, K., Takahashi, M., And Kurata, T., Human herpesvirus-6 in lymph nodes, Lancet 1: 40 (1989).CrossRefGoogle Scholar
  53. 52.
    Eizuru, Y., And Minamishima, Y., Evidence for putative immediate early antigens in human herpesvirus 6-infected cells, J. Gen. Virol. 73: 2161–2165 (1992).PubMedCrossRefGoogle Scholar
  54. 53.
    Enders, G., Biber, M., Meyer, G., And Helftenbein, E., Prevalence of antibodies to human herpesvirus 6 in different age groups, in children with exanthema subitum, other acute exanthematous childhood diseases, Kawasaki syndrome, and acute infections with other herpesviruses and Hiv, Infection 18: 12–15 (1990).PubMedCrossRefGoogle Scholar
  55. 54.
    Evans, A. S., Causation and disease: The Henle-Koch postulates revisited, Yale, J. Biol. Med. 49: 175–195 (1976).Google Scholar
  56. 55.
    Fairfax, M. R., Schacker, T., Cone, R. W., Collier, A C, And Corey, L., Human herpesvirus 6 Dna in blood cells of human immunodeficiency virus-infected men: Correlation of high levels with high CD4 cell counts, J. Infect. Dis. 169: 1342–1345 (1994).PubMedCrossRefGoogle Scholar
  57. 56.
    Fillet, A. M., Raguin, G., Agut, H., Boisnic, S., Agbogodeau, S., And Robert, C., Evidence of human herpesvirus 6 in Sjögren syndrome and sarcoidosis, Eur. J. Clin. Microbiol. Infect. Dis. 11: 564–566 (1992).PubMedCrossRefGoogle Scholar
  58. 57.
    Fo’A-TomAsi, L., Avitabile, E., KE, L., And Campadellifiume, G., Polyvalent and monoclonal antibodies identify major immunogenic proteins specific for human herpesvirus 7-infected cells and have weak cross-reactivity with human herpesvirus 6, J. Gen. Virol. 75: 2719–2727 (1994).CrossRefGoogle Scholar
  59. 58.
    Foucar, E., Rosai, J., And Dorfman, R. F., Sinus histiocytosis with massive lymphadenopathy (Rosai-Dorfman disease): Review of the entity, Semin. Diagn. Pathol. 7: 19–73 (1990).PubMedGoogle Scholar
  60. 59.
    Foucar, E., Rosai, J., And Dorfman, R. E, Sinus histiocytosis with massive lymphoadenopathy. An analysis of 14 deaths occurring in a patient registry, Cancer 54: 1834–1840 (1984).PubMedCrossRefGoogle Scholar
  61. 60.
    Fox, J., Briggs, M., And Tedder, R. S., Antibody to human herpesvirus 6 in Hiv-1 positive and negative homosexual men, Lancet 2: 396–397 (1988).PubMedCrossRefGoogle Scholar
  62. 61.
    Fox, J. D., Briggs, M., Ward, P. A., And Tedder, R., Human herpesvirus 6 in salivary glands, Lancet 336: 590–593 (1990).PubMedCrossRefGoogle Scholar
  63. 62.
    Frenkel, N., Schirmer, E. C., Wyatt, L. S., Katsafanas, G., Roffman, E., Danovich, R. M., And June, C. H., Isolation of a new herpesvirus from human CD4+ T cells, Proc. Natl. Acad. Sci. Usa 87: 748–752 (1990).PubMedCrossRefGoogle Scholar
  64. 63.
    Frenkel, N., And Wyatt, L. S., Hhv-6 and Hhv-7 as exogenous agents in human lymphocytes, in: Developments in Biological Standardization, Vol. 76 (F. Brown, E. E. Esber, And M. Williams, Eds.), pp. 259–265, Karger, Basal, 1992.Google Scholar
  65. 63a.
    Fukuda, K., Straus, S. E., Hickie, I., Sharpe, M. C., Dobbins, J. G., Komaroff, A., And The International Chronic Fatigue Syndrome Study Group, The chronic fatigue syndrome: A comprehensive approach to its definition and study, Ann. Intern. Med. 121: 953–959 (1994).CrossRefGoogle Scholar
  66. 64.
    Gopal, M. R., Thomson, B. J., Fox, J., Tedder, R. S., And HoNess, R. W., Detection by Pcr of Hhv-6 and Ebv Dna in blood and oropharynx of healthy adults and Hiv seropositives, Lancet 1: 1598–1599 (1990).CrossRefGoogle Scholar
  67. 65.
    Gompels, U. A., Carrigan, D. R., Carss, A. L., And Arno, J., Two groups of human herpesvirus 6 identified by sequence analyses of laboratory strains and variants from Hodgkin’s lymphoma and bone marrow transplant patients, J. Gen. Virol. 74: 613–622 (1993).PubMedCrossRefGoogle Scholar
  68. 66.
    Hagiwara, K., Komura, H., Kishi, E, Kaji, T., And Yoshida, T., Isolation of human herpesvirus-6 from an infant with Kawasaki disease (letter), Eur. J. Pediatr. 151: 867–868 (1992).PubMedCrossRefGoogle Scholar
  69. 67.
    Hall, C. B., Long, C. E., Schnabel, K. C., Caserta, M. T., Mcintyre, K. M., CoStanzo, M. A., KNoTT, A., Dewhurst, S., Insel, R. A., And Epstein, L. G., Human herpesvirus-6 infection in children. A prospective study of complications and reactivation, N. Engl. J. Med. 331: 432–438 (1994).PubMedCrossRefGoogle Scholar
  70. 68.
    Henle, G., And Henle, W., Immunofluorescence in cells derived from Burkitt’s lymphoma, J. Bacteriol. 91: 1248–1256 (1966).PubMedGoogle Scholar
  71. 69.
    Hidaka, Y., Liu, Y., Yamamoto, M., Mori, R., Miyazaki, C., Kusuhara, K., Okada, K., And Ueda, K., Frequent isolation of human herpesvirus 7 from saliva samples, J. Med. Virol. 40: 343–346 (1993).PubMedCrossRefGoogle Scholar
  72. 70.
    Hoffmann, A., Kirn, E., Kuerten, A., Sander, C. H., Krueger, G. R. F., And Ablashi, D. V., Active human herpesvirus-6 (Hhv-6) infection associated with Kikuchi-Fujimoto disease and systemic lupus erythematosus (Sle), In Vivo 5: 265–270 (1991).PubMedGoogle Scholar
  73. 71.
    Hollingsworth, H. C., Peiper, S. C., Weiss, L. M., Raffeld, M., And Jaffe, E. S., An investigation of the viral pathogenesis of Kikuchi-Fujimoto disease. Lack of evidence for Epstein-Barr virus or human herpesvirus type 6 as the causative agents, Arch. Pathol. Lab. Med. 118: 134–140 (1994).PubMedGoogle Scholar
  74. 72.
    Holmes, G. P., Kaplan, J. E., Gantz, N. M., Komaroff, A. L., Schonberger, L. B., Straus, S. E., Jones, J. F., DuBois, R. E., Cunningham-Rundles, C., Pahwa, S., Tosato, G., Zegans, L. S., Purtilo, D. T., Brown, N., Schooley, R. T., And Brus, I., Chronic fatigue syndrome: A working case definition, Ann. Intern. Med. 108: 387–439 (1988).PubMedCrossRefGoogle Scholar
  75. 73.
    Holmes, G. P., Kaplan, J. E., Stewart, J. A., Hunt, B., Pinsky, P. E, And Schonberger, L. B., A cluster of patients with a chronic mononucleosis-like syndrome: Is Epstein-Barr virus the cause? J.A.M.A. 257: 2297–2302 (1987).PubMedCrossRefGoogle Scholar
  76. 74.
    Horvat, R. T., Wood, C., And Balachandran, N., Transactivation of human immunodeficiency virus promoter by human herpesvirus 6, J. Virol. 63: 970–973 (1988).Google Scholar
  77. 75.
    Horwitz, C. A., And Beneke, J., Human herpesvirus-6 revisited, Am. J. Clin. Pathol. 99: 533–534 (1993).PubMedGoogle Scholar
  78. 76.
    Huang, L. M., Kuo, P. E, Lee, C. Y., Chen, J. Y., Liu, M. Y., And Yang, C. S., Detection of human herpesvirus-6 Dna by poly-merase chain reaction in serum or plasma, J. Med. Virol. 38: 7–10 (1992).PubMedCrossRefGoogle Scholar
  79. 77.
    Huang, L. M., Lee, C. Y., Lin, K. H., Chuu, W. M., Lee, P. I., Chen, R. L., Chen, J. M., And Lin, D. T., Human herpesvirus-6 associated with fatal haemophagocytic syndrome (letter), Lancet 60–61 (1990).Google Scholar
  80. 78.
    Irving, W. L., And Cunningham, A. L., Serological diagnosis of infection with human herpesvirus-6, Br. Med. J. 300: 156–159 (1990).CrossRefGoogle Scholar
  81. 79.
    Iyengar, S., Levine, P. H., Ablashi, D., Neequaye, J., And Pearson, G. R., Seroepidemiological investigations on human herpesvirus 6 (Hhv-6) infections using a newly developed early antigen assay, Int. J. Cancer 49: 551–557 (1991).PubMedCrossRefGoogle Scholar
  82. 80.
    James, V., And Freier, A., Roseola infantum: Outbreak in a maternity hospital, Arch. Dis. Child. 23–24:54–58 (1948–1949).Google Scholar
  83. 81.
    Jarrett, R. F., Gledhill, S., Qureshi, E, Crae, S. H., Madhok, R., Brown, I., Evans, I., Krajewski, A., O’Brien, C. J., Cartwright, R. A., Venables, P., And Onions, D. E., Identification of human herpesvirus 6-specific Dna sequences in two patients with non-Hodgkin’s lymphoma, Leukemia 2: 496–502 (1988).PubMedGoogle Scholar
  84. 82.
    Josephs, S. F., Buchbinder, A., Streicher, H. Z., Ablashi, D. V., Salahuddin, S. Z., Guo, H. G., Wong-Staal, F., Cossman, J., Raffeld, M., Sunden, J., Levine, P., Biggar, R., Krueger, G. R. F., Fox, R. I., And Gallo, R. C., Detection of human B-Iymphotropic virus (human herpesvirus 6) sequences in B cell lymphoma tissues of three patients, Leukemia 2: 132–135 (1988).PubMedGoogle Scholar
  85. 83.
    Jureti, M., Exanthema subitum: A review of 243 cases, Helv. Paediatr. Acta 18: 80–95 (1963).Google Scholar
  86. 84.
    Kakimoto, K., Ando, Y., Moriyama, I., And Ichuo, M., The significance of determination of human herpesvirus-6 (Hhv-6) antibody during pregnancy, Nippon Sanka Fujinka Gakkai Zasshi 44: 1571–1577 (1992).PubMedGoogle Scholar
  87. 85.
    Kawa-HA, K., Tanaka, K., Inoue, M., Sakata, N., Okada, S., Kurata, T., MuKai, T., And Yamanishi, K., Isolation of human herpesvirus 7 from a child with symptoms mimicking chronic Epstein-Barr virus infection, Br. J. Haematol. 84: 545–548 (1993).CrossRefGoogle Scholar
  88. 86.
    Keim, D. E., Keller, E. W., And Hirsch, M. S., Mucocutaneous lymph-node syndrome and parainfluenza 2 virus infection, Lancet 2: 303 (1977).PubMedCrossRefGoogle Scholar
  89. 87.
    Kempe, C. H., Shaw, 8. B., Jackson, J. It., And Silver, H. K., Studies on the etiology of exanthema subitum (roseola infantum), J. Pediatr. 37: 561–568 (1950).PubMedCrossRefGoogle Scholar
  90. 88.
    Kikuchi, M., Sumiyoshi, Y., And Minamishima, Y., Kukuchi’s disease (histiocytic necrotizing lymphadenitis), in: Human Herpesvirus-6: Epidemiology, Molecular Biology and Clinical Pathology. Perspectives in Medical Virology, Vol. 4 (D. V. Ablashi, G. R. E. Krueger, And S. Z. Salahuddin, Eds.), pp. 175–183, Elsevier, Amsterdam, 1992.CrossRefGoogle Scholar
  91. 89.
    KuxuTA, H., Lu, H., And Matsumoto, S., Susceptibility of human herpesvirus 6 to acyclovir (letter), Lancet 2: 861 (1989).Google Scholar
  92. 90.
    Klimas, N. G., Salvato, E R., Morgan, R., And Fletcher, M. A., Immunologic abnormalities in chronic fatigue syndrome, J. Clin. Microbiol. 28: 1403–1410 (1990).PubMedGoogle Scholar
  93. 91.
    Knowles, W., And Gardner, S., High prevalence of antibody to human herpesvirus 6 and seroconversion with rash in two infants, Lancet 2: 912–913 (1988).PubMedCrossRefGoogle Scholar
  94. 91a.
    KNox, K. K., And Carrigan, D. R., In vitro suppression of bone marrow progenitor cell differentiation by human herpesvirus 6 infection, J. Infect. Dis. 165:925–929 (1992).Google Scholar
  95. 92.
    KNox, K. K., And Carrigan, D. R., Disseminated active Hhv-6 infections in patients with Aids, Lancet 343: 577–578 (1994).PubMedCrossRefGoogle Scholar
  96. 93.
    Kondo, K., Nagafuji, H., Hata, A., Tomomori, C., And Yamanishi, K., Association of human herpesvirus 6 infection of the central nervous system with recurrence of febrile convulsions, J. Infect. Dis. 167: 1197–1200 (1993).PubMedCrossRefGoogle Scholar
  97. 94.
    Krueger, G. R. È, Manak, M., Bourgeois, N., Ablashi, D. V., Salahuddin, S. Z., Josephs, S. F., Buchbinder, A., Gallo, R. C., Berthold, F., And Tesch, H.; Persistent active herpes virus infection associated with atypical polyclonal lymphoproliferation (Apl) and malignant lymphoma, Anticancer Res. 9: 1457–1476 (1989).PubMedGoogle Scholar
  98. 95.
    Kurata, T., Iwasaki, T., Sata, T., Wakabayashi, T., Yamaguchi, K., Okuno, T., Yamanishi, K., And Takei, I., Viral pathology of human herpesvirus 6 infection, in: Immunobiology and Prophylaxis of Human Herpesvirus Infections (C. Lopez, R. Mori, B. Roizman, And R. J. Whitley, Eds.), pp. 39–47Google Scholar
  99. Plenum Press, New York. Lawrence, G. L., Chee, M., Craxton, M. A., Gompels, U. A., Honess, R: W., And Barrell, B. G., Human herpesvirus 6 is closely related to human cytomegalovirus, J. Vrml. 64: 287–299 (1990).Google Scholar
  100. 96.
    Leach, C. T., Newton, E. R., Mcparlin, S., And Jenson, H. B., Human herpesvirus 6 infection of the female genital tract, J. Infect. Dis. 169: 1281–1283 (1994).PubMedCrossRefGoogle Scholar
  101. a. Levine, P. H., And Ablashi, D. V., The new herpesviruses: Hhv-7 and Hhv-8 (KS-virus), Infections in Medicine (in press).Google Scholar
  102. 97.
    Levine, P. H., Ablashi, D. V., Saxinger, W. C., And Connelly, R. R., Antibodies to human herpesvirus-6 in patients with acute lymphocytic leukemia, Leukemia 6: 1229–1231 (1992).PubMedGoogle Scholar
  103. 98.
    Levine, P. H., Ebbesen, E, Ablashi, D. V., Saxinger, W. C., NoRdentofr, A., And Connelly, R. R., Antibodies to human herpes virus type 6 and clinicallcourse in patients with Hodgkin’s disease, Int. J. Cancer 51: 53–57 (1992).PubMedCrossRefGoogle Scholar
  104. 99.
    Levine, P. H., Jacobson, S., Pocinki, A. G., Cheney, P., Peterson, D., Connelly, R. R., Weil, R., Robinson, S. M., Ablashi, D. V., Salahuddin, S. Z., Pearson, G. R., And Hoover, R., Clinical, epidemiologic, and virologic studies in four clusters of the chronic fatigue syndrome, Arch. Intern. Med. 152: 1611–1616 (1992).PubMedCrossRefGoogle Scholar
  105. 100.
    Levine, P. H., Jahan, N., Murari, P., Mank, M., And Jaffe, E. S., Detection of human herpesvirus 6 in tissues involved by sinus histiocytosis with massive lymphadenopathy Rosai-Dorfman disease, J. Infect. Dis. 166: 291–295 (1992).PubMedCrossRefGoogle Scholar
  106. 101.
    Levine, P. H., Jarrett, R., And Clark, D. A., The epidemiology of human herpesvirus-6, in: Human Herpesvirus-6: Epidemiology, Molecular Biology and Clinical Pathology (D. V. Ablashi, G. R. F. Krueger, And S. Z. Salahuddin, Eds.), pp. 9–23, Elsevier, Amsterdam, 1992.CrossRefGoogle Scholar
  107. 102.
    Levine, P. H., Krueger, G. R. F., Kaplan, M., Bell, D., Dubois, R.E., Huang, A., Quinlan, A., Buchwald, D., AR-Chard, L., Gupta, S., Jones, J., Straus, S., And Tosato, G., The postinfectious chronic fatigue syndrome, in: Epstein-Barr Virus and Human Disease (D. V. Ablashi, A. T. HuAng, J. S. Pagano, ET AL., Eds.), pp. 405–438, Humana Press, Clifton, NJ, 1989.Google Scholar
  108. 103.
    Levine, P. H., Neequaye, J., Yadav, M., And Connelly, R., Geographic/ethnic differences. in human herpesvirus-6 antibody patterns, Microbiol. Immunol. 36: 169–172 (1992).PubMedGoogle Scholar
  109. 104.
    Levy, J. A., Ferro, F., Greenspan, D., And LennerrE, E. T., Frequent isolation of Hhv-6 from saliva and high seroprevalence of the virus in the population, Lancet 335: 1047–1050 (1990).PubMedCrossRefGoogle Scholar
  110. 105.
    Levy, J., Landay, A., And Lennette, E., Human herpesvirus 6 inhibits human immunodeficiency virus type 1 replication in cell culture, J. Clin. Microbiol. 28: 2362–2364 (1990).PubMedGoogle Scholar
  111. 106.
    Lopez, C., Pellett, P., Stewart, J., Goldsmith, C., Sander-Lin, K., Black, J., Warfield, D., And Feorino, P., Characteristics of human herpesvirus-6 (letter), J. Infect. Dis. 157: 1271–1273 (1988).Google Scholar
  112. 107.
    LuPpi, M., Marasca, R., Barozzi, E, Artusi, T., And Torelli, G., Frequent detection of human herpesvirus-6 sequences by polymerase chain reaction in paraffin-embedded lymph nodes from patients with angioblastic lymphadenopathy and angioimmunoblastic lymphadenopathy-like lymphoma, Leuk. Res. 17: 1003–1111 (1993).CrossRefGoogle Scholar
  113. 108.
    Lusso, P., Ablashi, D. V., And Luka, J., Interactions between Hhv-6 and other viruses, in: Human Herpesvirus-6: Epidemiology, Molecular Biology and Clinical Pathology. Perspectives in Medical Virology, Vol. 4 (D. Ablashi, G. R. F. Krueger, And S. Z. Salahuddin, Eds.), pp. 121–133, Elsevier, Amsterdam, 1992.CrossRefGoogle Scholar
  114. 110.
    Lusso, P., Malnati, M. S., Garzino-Demo, A., Crowley, R. W., Long, E. O., And Gallo, R. C., Infection of natural killer cells by human herpesvirus-6, Nature 362: 458–462 (1993).PubMedCrossRefGoogle Scholar
  115. 111.
    Lusso, P., Markham, P. D., Tschachler, E., Veronese, F. D. M., Salahuddin, S. Z., Ablashi, D. V., Pahwa, S., Krohn, K., And Gallo, R. C., In vitro cellular tropism of human B-lymphotropic virus (human herpesvirus-6), J. Exp. Med. 167:1659–1670 (1988).Google Scholar
  116. 112.
    Maeda, A., Sata, T., Enzan, H., Tanaka, K., Wakiguchi, H., Kurashige, T., Yamanishi, K., And Kurata, T., The evidence of human herpesvirus 6 infection in the lymph nodes of Hodgkin’s disease, Virchows. Arch. A Pathol. Anat. Histopathol. 423 (1): 71–75 (1993).PubMedCrossRefGoogle Scholar
  117. 113.
    Merelli, E., Sola, P., Faglioni, P., Poggi, M., Montorsi, M., And Torelli, G., Newest human herpesvirus (Hhv-6) in the Guillain-Barré syndrome and other neurological diseases, Acta Neural. Scand. 85: 334–336 (1992).CrossRefGoogle Scholar
  118. 114.
    Merlino, C., Sinesi, F., Messina, M., Giacchino, F., And Negro Ponzi, A., Infection by human herpesvirus type 6 (Hhv-6) and renal transplantation, Minerva Urol. Nefrol. 44: 157–153 (1992).Google Scholar
  119. 115.
    Nakagami, T., Taji, S., Takahashi, M., And Yamanishi, K., Antiviral activity of a bile pigment, biliverdin, against human herpesvirus 6 (Hhv-6) in vitro, Microbiol. Immunol. 36: 381–390 (1992).PubMedGoogle Scholar
  120. 116.
    Niederman, J. C., Lin, C.-R., Kaplan, M. H., And Brown, N. A., Clinical and serological features of human herpesvirus-6 infection in three adults, Lancet 2: 817–819 (1988).PubMedCrossRefGoogle Scholar
  121. 117.
    Hishimura, K., And Igarashi, M., Thrombotic thrombocytopenic purpura associated with exanthem subitum, Pediatrics 60: 260 (1972).Google Scholar
  122. 118.
    Okano, M., Luka, J., Thiele, G. M., Sakiyama, Y., Matsumoto, S., And Purtilo, D. T., Human herpesvirus-6 infection and Kawasaki disease, J. Clin. Microbiol. 27: 2379–2380 (1989).PubMedGoogle Scholar
  123. 119.
    Okuno, T., Takahashi, K., Balachandra, K., Shiraki, K., Yamanishi, K., Takahashi, M., And Baba, K., Seroepidemiology of human herpesvirus 6 in normal children and adults, J. Clin. Microbiol. 27: 651–653 (1989).PubMedGoogle Scholar
  124. 120.
    Pallesen, G., Hamilton-Dutoit, S. J., Rowe, M., And Young, L. S., Expression of Epstein-Barr virus latent gene products in tumour cells of Hodgkin’s disease, Lancet 337: 320–322 (1991).PubMedCrossRefGoogle Scholar
  125. 121.
    Pietroboni, G. R., Harnett, G. B., Bucens, M. R., And Honess, R. W., Isolation of human herpes-virus-6 from saliva, Lancet 1: 1059 (1988).PubMedCrossRefGoogle Scholar
  126. 122.
    Pietroboni, G. R., Harnett, G. B., Farr, T. J., And Bucens, M. R., Human herpesvirus type 6 (Hhv-6) and its in vitro effect on human immunodeficiency virus (Hiv), J. Clin. Pathol. 41: 13101312 (1988).Google Scholar
  127. 123.
    Porlotani, M., Cermelli, C., Moroni, A., Bertolani, M. E, DI Luca, D., Cassai, E., And Sabbatini, A. M., Human herpesvirus-6 infections in infants admitted to hospital, J. Med. Virol. 39: 146–151 (1993).CrossRefGoogle Scholar
  128. 124.
    Prezioso, P. J., Cangiarella, J., Lee, M., Nuovo, G. J., BoRkowsky, W., Orlow, S. J., And Greco, M. A., Fatal disseminated infection with human herpesvirus-6, J. Pediatr. 120: 921923 (1992).Google Scholar
  129. 125.
    Prussia, P. R., Mansoor, G. A., Edwards, C., And Jordan, O., Haemophagocytic syndrome, West Indian Med. J. 40: 188–192 (1991).PubMedGoogle Scholar
  130. 126.
    Pruksananonda, P., Hall, C. B., Insel, R. A., Mcintyre, K., Pellett, P. E., Long, C. E., Schnabel, K. C., Pincus, P. H., Stamey, F. R., Dambaugh, T. R., And Stewart, J. A., Primary human herpesvirus 6 infection in young children, N. Engl. J. Med. 326: 1445–1450 (1992).PubMedCrossRefGoogle Scholar
  131. 127.
    Qavi, H. B., Green, M. T., Segall, G. K., Lewis, D. E., And Hollinger, E. B., Frequency of dual infections of corneas with Hiv-1 and Hhv-6, Curr. Eye Res. 11: 315–323 (1992).PubMedCrossRefGoogle Scholar
  132. 128.
    Qavi, H. B., Green, M. T., And Segall, G. K., Hiv-1 and Hhv-6 infections of human retina and cornea, in: Human Herpesvirus-6: Epidemiology, Molecular Biology and Clinical Pathology. Perspectives in Medical Virology, Vol. 4 (D. V. Ablashi, G. R. F. Krueger, And S. Z. Salahuddin, Eds.)„ pp. 263–280, Elsevier, Amsterdam, 1992.CrossRefGoogle Scholar
  133. 129.
    Ranger, S., Patillaud, S., Denis, F., Himmich, A., Sangare, A., M’BouP, S., Ztoua-N’Gaporo, A., Prince-David, M., Chout, R., Cevallos, R., And Agut, H., Seroepidemiology of human herpesvirus-6 in pregnant women from different parts of the world, J. Med. Virol. 34: 194–198 (1991).PubMedCrossRefGoogle Scholar
  134. 130.
    Reiner, A. P., And Spivak, J. L., Hematophagic histiocytosis. A report of 23 new patients and a review of the literature, Medicine 67: 369–388 (1988).PubMedCrossRefGoogle Scholar
  135. 131.
    Reux, I., Fillet, A. M., Agut, H., Katlama, C., Hauw, J. J., And Lehoang, P., In situ detection of human herpesvirus 6 in retinitis associated with acquired immunodeficiency syndrome (letter), Am. J. Ophthalmol. 114:375–377 (1992).Google Scholar
  136. 132.
    Risdall, R. J., McKenna, R. W., Nesbit, M. E., Krivit, W., Balfour, H. H., Simmons, R. L., And Brunning, R. D., Virusassociated hemophagocytic syndrome. A benign histiocytic proliferation distinct from malignant histiocytosis, Cancer 44: 993–1002 (1979).PubMedCrossRefGoogle Scholar
  137. 133.
    Russler, S. K., Tapper, M. A., And Carrigan, D. R., Susceptibility of human herpesvirus 6 to acyclovir and ganciclovir, Lancet 2: 382 (1989).PubMedCrossRefGoogle Scholar
  138. 134.
    Salahuddin, S. Z., The discovery of human herpesvirus type 6, in: Human Herpesvirus-6: Epidemiology, Molecular Biology and Clinical Pathology. Perspectives in Medical Virology, Vol. 4 (D. V. Ablashi, G. R. F. Krueger, And S. Z. Salahuddin, Eds.), pp. 3–8, Elsevier, Amsterdam, 1992.CrossRefGoogle Scholar
  139. 135.
    Salahuddin, S. Z., Ablashi, D. V., Markham, P. D., Josephs, S. F., Sturzenegger, S., Kaplan, M., Halligan, G., Biberfeld, P., Wong-Staal, F., Kramarsky, B., And Gallo, R. C., Isolation of a new virus, Hblv, in patients with lymphoproliferative disorders, Science 234: 596–601 (1986).PubMedCrossRefGoogle Scholar
  140. 136.
    Sato, T., Indue, T., Kajiwara, M., Miyazaki, C., Kusunoki, K., And Uedo, K., Acute encephalopathy following exanthem subitum caused by human herpesvirus-6, Kansenshogaku Zasshi 66: 551–554 (1992).PubMedGoogle Scholar
  141. 137.
    Saranath, D., Mukhopadhyaya, R., Rao, R. S., Fakih, A. R., Naik, S. J., And Gangal, S. G., Cell-mediated immune status in patients with squamous cell carcinoma of the oral cavity, Cancer 56: 1062–1070 (1985).PubMedCrossRefGoogle Scholar
  142. 138.
    Saxinger, C., Polesky, H., Eby, N., Grufferman, S., Murphy, R., Tegtmeir, G., Parekh, V., Memon, S., And Hung, C., Antibody reactivity with Hblv (Hhv-6) in U.S. populations, J. Virol. Methods 21: 199–208 (1988).PubMedCrossRefGoogle Scholar
  143. 139.
    Schirmer, E. C., Wyatt, L. S., Yamanishi, K., Rodriguez, W. J., And Frenkel, N., Differentiation between two distinct classes of viruses now classified as human herpesvirus 6, Proc. Natl. Acad. Sci. Usa 88: 5922–5926 (1991).PubMedCrossRefGoogle Scholar
  144. 140.
    Scott, D. A., And Constantine, N. T., Human herpesvirus type 6 and Hiv infection in Africa, Aids 11: 1161–1162 (1990).CrossRefGoogle Scholar
  145. 141.
    Shanavas, K. R., Kala, V., Vasudevan, D. M., Vijayakumar, T., And Yadav, M., Anti-Hhv-6 antibodies in normal population and in cancer patients in India, J. Exp. Pathol. 6: 95–105 (1992).PubMedGoogle Scholar
  146. 142.
    Shen, Y. Y., Huang, A. M., Jahan, N., Manak, M., Jaffe, E. S., And Levine, P. H., In situ hybridization detection of human herpesvirus-6 in biopsy specimens from Chinese patients with non-Hodgkin’s lymphoma, Arch. Pathol. Lab. Med. 117:502–506 (1993).Google Scholar
  147. 143.
    Shibata, D., And Weiss, L. M., Epstein-Barr virus-associated gastric adenocarcinoma, Am. J. Pathol. 140: 769–774 (1992).PubMedGoogle Scholar
  148. 144.
    Shiraki, K., Okuno, T., Yamanishi, K., And Takahashi, M., Phosphonoacetic acid inhibits replication of human herpesvirus-6, Antiviral Res. 12: 311–318 (1989).PubMedCrossRefGoogle Scholar
  149. 145.
    Simmons, A., Demmrich, Y., LA Vista, A., And Smith, K., Replication of human herpesvirus 6 in epithelial cells in vitro, J. Infect. Dis. 166: 202–205 (1992).PubMedCrossRefGoogle Scholar
  150. 146.
    Sobue, R., Miyazaki, H., Okamoto, M., Hirano, M., Yoshikawa, T., Suga, S., And Asano, Y., Fulminant hepatitis in primary human herpesvirus-6 infection, N. Engl. J. Med. 324: 1290 (1991).PubMedCrossRefGoogle Scholar
  151. 147.
    Spira, T. J., Bozeman, L. H., Sanderlin, K. C., Warfield, D. T., Feorino, P. M., Holman, R. C., Kaplan, J. E., Fishbein, D. B., And Lopez, C, Lack of correlation between human herpesvirus-6 infection and the course of human immunodeficiency virus infection, J. Infect. Dis. 161: 567–570 (1990).PubMedCrossRefGoogle Scholar
  152. 148.
    Steeper, T. A., Horwitz, C. A., Ablashi, D. V., Salahuddin, S. Z., Saxinger, C., Saltzman, R., And Schwartz, B., The spectrum of clinical and laboratory findings resulting from human herpesvirus-6 (Hhv-6) in patients with mononucleosis-like illnesses not resulting from Epstein-Barr virus or cytomegalovirus, Am. J. Clin. Pathol. 93: 776–783 (1990).PubMedGoogle Scholar
  153. 149.
    Stevens, J. G., Human herpesviruses: A consideration of the latent state, Microbiol. Rev. 53: 318–332 (1989).Google Scholar
  154. 150.
    Straus, S. E., Fritz, S., Dale, J. K., Gould, B., And Strober, W., Lymphocyte phenotype and function in the chronic fatigue syndrome, J. Clin. Immunol. 13: 30–40 (1993).PubMedCrossRefGoogle Scholar
  155. 151.
    Streicher, H. Z. Hung, C. L., Ablashi, D. V., Hellman, K., Saxinger, C., Fullen, J., And Salahuddin, S. Z., In vitro inhibition of human herpesvirus-6 by phosphonoformate, J. Virol. Methods 21:301–304 (1988).Google Scholar
  156. 152.
    Suga, S., Yoshikawa, T., Asano, Y., Nakashima, T., Kobayashi, I., And Yazaki, T., Human herpesvirus-6 infection (exanthem subitum) without rash, Pediatrics 83: 1003–1006 (1989).PubMedGoogle Scholar
  157. 153.
    Suga, S., Yoshikawa, T., Asano, Y., Nakashima, T., Kobayashi, I., And Yazaki, T., Activation of human herpesvirus-6 in children with acute measles, J. Med. Virol. 38: 278–282 (1992).PubMedCrossRefGoogle Scholar
  158. 154.
    Suga, S., Yoshikawa, T., Asano, Y., Nakashima, T., Yazaki, T., Fukuda, M., Kojima, S., Matsuyama, T., Ono, Y., And Oshima, S., IgM neutralizing antibody responses to human herpesvirus-6 in patients with exanthem subitum or organ transplantation, Microbiol. Immunol. 36: 495–506 (1992).PubMedGoogle Scholar
  159. 155.
    Sumiyoshi, Y., Kikuchi, M., Ohshima, K., Yoneda, S., KoBari, S., Takeshita, M., Eizura, Y., And Minamishima, Y., Human herpesvirus-6 genomes in histiocytic necrotizing lymphadenitis (Kikuchi’s disease) and other forms of lymphadenitis, Am. J. Clin. Pathol. 99: 609–614 (1993).PubMedGoogle Scholar
  160. 156.
    Tagawa, S., Mizuki, M., Ono’, U., Nakamura, Y., Nozima, J., Yoshida, H., Kondo, K., Mukai, T., Yamanishi, K., And Kitani,T., Transformation of large granular lymphocytic leukemia during the course of a reactivated human herpesvirus-6 infection, Leukemia 6: 465–469 (1992).PubMedGoogle Scholar
  161. 157.
    Tajiri, H., Nose, O., Baba, K., And Okada, S., Human herpes virus-6 infection with liver injury in neonatal hepatitis, Lancet 335: 863 (1990).Google Scholar
  162. 158.
    Takahashi, K., Sonoda, S., Kawakami, K., Miyata, K., OK’, T., Nagata, T., Okuno, T., And Yamanishi, K., Human herpesvirus-6 and exanthem subitum, Lancet 1: 1463 (1988).PubMedCrossRefGoogle Scholar
  163. 159.
    Takikawa, T., Hayashibara, H., Harada, Y., And Shiraki, K., Liver dysfunction anaemia and granulocytopenia after exanthema subitum (letter), Lancet 340: 1288–1289 (1992).PubMedCrossRefGoogle Scholar
  164. 160.
    Tanaka, K., Kondo, T., Torigoe, S., Okada, S., Mukai, T., And Yamanishi, K., Human herpesvirus 7: Another casual agent for roseola (exanthem subitum), J. Pediatr. 125: 1–5 (1994).PubMedCrossRefGoogle Scholar
  165. 161.
    Torelli, G, Marasca, R., Luppi, M., Sellers, L., Ferrari, S., Narni, F., Mariano, M. T., Federico, M., Ceccherini-Neilli, L., Bondinelli, M, Montagnani, G., Montorsi, M., And Artusi, T., Human herpesvirus-6 in human lymphomas: Identification of specific sequences in Hodgkin’s lymphomas by polymerase chain reaction, Blood 77: 2251–2258 (1991).PubMedGoogle Scholar
  166. 162.
    Torelli, G., Marasca, R., Montorsi, M., Luppi, M., Barozzi, P, Ceccherini, L., Batons, G., Bendinelli, M., And Muyom Bano, A., Human herpesvirus 6 in non-Aids related Hodgkin’s and non-Hodgkin’s lymphomas, Leukemia 6 (Suppl. 3): 46S - 48S (1992).PubMedGoogle Scholar
  167. 162a.
    Torigoe, S., Kumamoto, T., Koide, W., Taya, K., And Yamanishi, K., Clinical manifestations associated with human herpesvirus 7 infection, Arch. Dis. Child. (England) 72 (6): 518–519 (1995).Google Scholar
  168. 163.
    Viza, D., Aranda-Anzaldo, A., Ablashi, D., And Kramarsky, B., Hhv-6 inhibition by two polar compounds, Antiviral Res. 18:27–38 (1992). (Erratum 19: 179, 1992 )Google Scholar
  169. 164.
    Weiss, L. M., Movahed, L. A., Warnke, R. A., And Sklar, J., Detection of Epstein-Barr viral genomes in Reed-Sternberg cells of Hodgkin’s disease, N. Engl. J. Med. 320: 502–506 (1989).PubMedCrossRefGoogle Scholar
  170. 165.
    Whitby, D., Hoad, J. G., Tizard, E. J., Dillon, M. J., Weber, J. N., Weiss, R. A., And Schulz, T. F., Isolation of measles virus from a child with Kawasaki disease, Lancet 338: 1215 (1991).PubMedCrossRefGoogle Scholar
  171. 166.
    Williams, M. V., Hhv-6: Response to antiviral agents, in: Human Herpesvirus-6: Epidemiology, Molecular Biology and Clinical Pathology. Perspectives in Medical Virology, Vol. 4 (D. V. Ablashi, G. R. F. Krueger, And S. Z. Salahuddin, Eds.), pp. 317–335, Elsevier, Amsterdam, 1992.CrossRefGoogle Scholar
  172. 167.
    Wyatt, C. S., Balachandran, N., And Frenkel, N., Variations in the replication and antigenic properties of human herpesvirus-6 strains, J. Infect. Dis. 162: 852–857 (1990).PubMedCrossRefGoogle Scholar
  173. 168.
    Wyatt, L. S., And Frenkel, N., Human herpesvirus 7 is a constitutive inhabitant of adult human saliva, J. Virol. 66: 3206–3209 (1992).PubMedGoogle Scholar
  174. 169.
    Wyatt, L. S., Rodriguez, W. J., Balachandran, N., And Frenkel, N., Human herpesvirus 7: Antigenic properties and prevalence in children and adults, J. Virol. 65: 6260–6265 (1991).PubMedGoogle Scholar
  175. 170.
    Yadav, M., Chandrashekran, A., Vasudevan, D. M., And Ablashi, D. V., Frequent detection of human herpesvirus 6 in oral carcinoma, J. Natl. Cancer Inst. 86: 1792–1794 (1994).PubMedCrossRefGoogle Scholar
  176. 171.
    Yamanishi, K., Kondo, K., Mukai, T., Kondo, T., Nagafuji, H., Kato, T., Okuno, T., And Kurata, T., Human herpesvirus 6 (Hhv-6) infection in the central nervous system, Acta Paediatr. Jpn. 34: 337–343 (1992).PubMedCrossRefGoogle Scholar
  177. 172.
    Yamanishi, K., Okuno, T., Shiraki, K., Takahashi, M., Kondo, T., Asano, Y., And Kurata, T., Identification of human herpesvirus-6 as a causal agent for exanthem subitum, Lancet 1: 1065–1067 (1988).PubMedCrossRefGoogle Scholar
  178. 173.
    Yoshikawa, T., Asano, Y., Kobayashi, I., Nakashima, T., Yazaki, T., Suga, S., Ozaki, T., Wyatt, L. S., And Frenkel, N., Seroepidemiology of human herpesvirus 7 in healthy children and adults in Japan, J. Med. Virol. 41: 319–323 (1993).PubMedCrossRefGoogle Scholar
  179. 174.
    Yoshikawa, T., Nakashima, T., Suga, S., Asano, Y., Yazaki, T., KimÜRA, H., Morishima, T., Kondo, K., And Yamanishi, K., Human herpesvirus-6 Dna in cerebrospinal fluid of a child with exanthem subitum and meningoencephalitis, Pediatrics 89: 888–890 (1992).PubMedGoogle Scholar
  180. 175.
    Yoshikawa, T., Suga, S., Asano, Y., Nakashima, T., Yazaki, T., Sobue, R., Hirano, M., Fukuda, M., Komma, S., And Matsuyama, T., Human herpesvirus-6 infection in bone marrow transplantation, Blood 78: 1381–1384 (1991).PubMedGoogle Scholar
  181. 176.
    Yoshikawa, T., Suga, S., Asano, Y., Nakashima, T., Yazaki, T., Ono, Y., Fujita, T., Tsuzuki, K., Sugiyama, S., And Oshima, S., A prospective study of human herpesvirus-6 infection in renal transplantation, Transplantation 54: 879–883 (1992).PubMedCrossRefGoogle Scholar
  182. 177.
    Zahorsky, J., Roseola infantum, J.A.M.A. 61: 1445–1450 (1913).CrossRefGoogle Scholar
  183. Ablashi, D. V., Krueger, G. R. F., And Salahuddin, S. Z. (Eds.), Human Herpesvirus-6: Epidemiology, Molecular Biology and Clinical Pathology. Perspectives in Medical Virology, Vol. 4. Elsevier, Amsterdam, 1992.Google Scholar
  184. Leach, C. T., Sumaya, C. V., And Brown, N. A., Human herpesvirus-6 clinical implications of a recently discovered ubiquitous agent, J. Pediatr. 121: 173–181 (1992).PubMedCrossRefGoogle Scholar
  185. Oren, I., And Sobel, J. D., Human herpesvirus type 6: Review, Clin. Infect. Dis. 14: 741–746 (1992).PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1997

Authors and Affiliations

  • Paul H. Levine
    • 1
  1. 1.Viral Epidemiology BranchNational Cancer InstituteBethesdaUSA

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