Epidemiologic Concepts and Methods

  • Richard A. Kaslow
  • Alfred S. Evans

Abstract

The epidemiology of infectious diseases is concerned with the circumstances under which both infection and disease occur in a population and the factors that influence their frequency, spread, and distribution. This concept distinguishes between infection and disease because the factors that govern their occurrence may be different and because infection without disease is common with many viruses. Infection indicates the introduction and multiplication of a biological agent within a host, leading to an interaction often manifest as an immune response. It is determined largely by factors that govern exposure to the agent and by the susceptibility of the host. Disease represents the host response to infection when it is severe enough to evoke a recognizable pattern of clinical symptoms. The factors that influence the occurrence and severity of this response vary with the particular viruses involved and their portal of entry, but the most important determinants for many common infections lie within the host itself. Of these, the age at the time of infection, genetic background, and immune status of the host are the most crucial.

Keywords

Human Immunodeficiency Virus Human Leukocyte Antigen Respiratory Syncytial Virus Human Immunodeficiency Virus Infection Infectious Mononucleosis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1997

Authors and Affiliations

  • Richard A. Kaslow
    • 1
  • Alfred S. Evans
    • 2
  1. 1.Department of Epidemiology, School of Public HealthUniversity of Alabama at BirminghamBirminghamUSA
  2. 2.Department of Epidemiology and Public HealthYale University School of MedicineNew HavenUSA

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