Epidemiologic Concepts and Methods

  • Richard A. Kaslow
  • Alfred S. Evans


The epidemiology of infectious diseases is concerned with the circumstances under which both infection and disease occur in a population and the factors that influence their frequency, spread, and distribution. This concept distinguishes between infection and disease because the factors that govern their occurrence may be different and because infection without disease is common with many viruses. Infection indicates the introduction and multiplication of a biological agent within a host, leading to an interaction often manifest as an immune response. It is determined largely by factors that govern exposure to the agent and by the susceptibility of the host. Disease represents the host response to infection when it is severe enough to evoke a recognizable pattern of clinical symptoms. The factors that influence the occurrence and severity of this response vary with the particular viruses involved and their portal of entry, but the most important determinants for many common infections lie within the host itself. Of these, the age at the time of infection, genetic background, and immune status of the host are the most crucial.


Human Immunodeficiency Virus Human Leukocyte Antigen Respiratory Syncytial Virus Human Immunodeficiency Virus Infection Infectious Mononucleosis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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  1. 1.
    Aach, R. D., Szmuness, W., Mosely, J. W., Hollinger, F. B., Kahn, R. A., Stevens, C. E., Edwards, V. M., and Welch, J., Serum alanine aminotransferase of donors in relation to the risk of non-A, non-B hepatitis in recipients, N. Engl. J. Med. 304: 989–994 (1981).Google Scholar
  2. 2.
    Abbey, H., An examination of the Reed-Frost theory of epidemics, Hum. Biol. 24: 201–233 (1952).PubMedGoogle Scholar
  3. 3.
    Adam, E., Kaüfman, R. H., Adlerstorhz, J. H., Melnick, J. L., and Dreesman, G. R., A prospective study of association of herpes simplex virus and papilloma virus infection with cervical neoplasia in women exposed to diethylstilbesterol in utero, Int. J. Cancer 35: 19–26 (1985).PubMedCrossRefGoogle Scholar
  4. 4.
    Alter, H. J., Posttransfusion hepatitis: Clinical features, risk and donor testing, in: Infection, Immunity and Blood Transfusion (R. Y. Donn, and L. F. Barker, eds.), pp. 47–61, Liss, New York, 1984.Google Scholar
  5. 5.
    Anderson, R. M., and May, R. M., Vaccination against rubella and measles: Quantitative investigations of different policies, J. Hyg. (Camb.) 90: 259–325 (1983).CrossRefGoogle Scholar
  6. 6.
    Anderson, R. M., Gupta, S., and May, R. M., Potential of community-wide chemotherapy or immunotherapy to control the spread of HIV-1, Nature 350: 356–359 (1991).PubMedCrossRefGoogle Scholar
  7. 7.
    Arduino, R. C., and Dupont, H. L., Travellers’ diarrhoea, Baillieres Clin. Gastroenterol. 7: 365–385 (1993).PubMedCrossRefGoogle Scholar
  8. 8.
    Armstrong, J. A., Evans, A. S., Rao, N., and HO, M., Viral infections in renal transplant recipients, Infect. Immun. 14: 970–975 (1976).PubMedGoogle Scholar
  9. 9.
    Ashton, L. J., Learmont, J., Luo, K., Wylie, B., and Stewart, G., HIV infections in recipients of blood products from donors with known duration of infection, Lancet 344: 718–720 (1994).PubMedCrossRefGoogle Scholar
  10. 10.
    Bacchetti, P., Estimating the incubation period of AIDS by comparing population infection and diagnosis patterns, J. Am. Stat. Assoc. 85: 1002–1008 (1990).CrossRefGoogle Scholar
  11. 11.
    Bachetti, P., and Moss, A. R., Incubation period of AIDS in San Francisco, Nature 338: 251–253 (1989).CrossRefGoogle Scholar
  12. 12.
    Bailey, N. T. J., The Mathematical Theory of Infectious Diseases, 2nd ed., Macmillan, New York, 1975.Google Scholar
  13. 13.
    Baron, R. C., Dicker, R. C., Bussell, K. E., and Herndon, J. L., Assessing trends in mortality in 121 U.S. cities, 1970–79, from all causes and from pneumonia and influenza, Public Health Rep. 103: 120–128 (1988).PubMedGoogle Scholar
  14. 14.
    Barron, K. S., Kawasaki disease: Epidemiology, late prognosis, and therapy, Rheum. Dis. Clin. North Am. 17: 907–919 (1991).PubMedGoogle Scholar
  15. 15.
    Bauer, H. M., Ting, Y., Greer, C. E., Chambers, J. C., Tashiro, C. J., Chimera, J., Reingold, A., and Manos, M. M., Genital human papilloma virus infection in female university students as determined by a PCR-based method, J.A.M.A. 265: 472–477 (1991).PubMedCrossRefGoogle Scholar
  16. 16.
    Baumgartner, I., and Klebs, E., A centennial note, N. Engl. J. Med. 213: 60–63 (1935).CrossRefGoogle Scholar
  17. 17.
    Bean, B., Antiviral therapy: Current concepts and practices, Clin. Microbiol. 5: 146–182 (1992).Google Scholar
  18. 18.
    Beasley, P., Hwang, P-Y., Lin, C.-Y., and Chien, C.-S., Hepatocellular carcinoma and hepatitis B virus. A prospective study of 22707 men in Taiwan, Lancet 2: 1129–1132 (1981).PubMedCrossRefGoogle Scholar
  19. 19.
    Beasley, R. P., and Hwang, L.-Y., Overview of the epidemiology of hepatocellular carcinoma, in: Viral Hepatitis and Liver Disease (F. B. Hollinger, S. M. Lemon, and H. S. Margolis, eds.), pp. 532–535, Williams and Wilkins, Baltimore, 1991.Google Scholar
  20. 20.
    Bell, D. M., Brink, E. W., Nitzkin, J. L., Hall, C. B., Wulff, H., and Berkowitz, I. D., Kawasaki syndrome. Description of two outbreaks in the United States, N. Engl. J. Med. 304: 1568–1575 (1981).PubMedCrossRefGoogle Scholar
  21. 21.
    Bell, J. A., Rowe, W. P., Engler, J. L., Parrot, R. H., and Huebner, R. J., Pharyngeal conjunctival fever: Epidemiological studies of a recent recognized disease entity, J.A.M.A. 175: 1083–1092 (1955).CrossRefGoogle Scholar
  22. 22.
    Benenson, A. S., (ED.), Control of Communicable Diseases in Man, 16th ed., American Public Health Association, Washington, 1995.Google Scholar
  23. 23.
    Berger, J. R., and Levy, J., The human immunodeficiency virus type 1-the virus and its role in neurologic disease, Semin. Neurol. 12: 1–9 (1992).PubMedCrossRefGoogle Scholar
  24. 24.
    Berkelman, R., Bryan, R. T., Osterholm, M. T., LeDuc, J. W., and Hughes, J. M., Infectious diseases surveillance: A crumbling infrastructure, Science 264: 368–370 (1994).PubMedCrossRefGoogle Scholar
  25. 25.
    Berman, S., and McIntosh, K., Selective primary health care. Strategies for control of disease in the developing world. XXI. Acute respiratory infections, Rev. Infect. Dis. 7: 674–691 (1985).Google Scholar
  26. 26.
    Bishop, R. F., Davidson, G. E, Holmes, I. H., and Ruck, B. J., Virus particles in epithelial cells of duodenal mucosa from children with acute nonbacterial gastroenteritis, Lancet 2: 1281–1293 (1973).PubMedCrossRefGoogle Scholar
  27. 27.
    Bishop, R. F., Davidson, G. P., Holmes, I. H., and Ruck, B. J., Detection of a new virus by electron microscopy of fecal extracts of children with acute gastroenteritis, Lancet 1: 149–151 (1974).PubMedCrossRefGoogle Scholar
  28. 28.
    Bisno, A. L., Barratt, N. P., SEvanson, W. H., and Spense, L. P., An outbreak of acute respiratory disease in Trinidad associated with para-influenza virus, Am. J. Epidemiol. 91: 68–77 (1970).PubMedGoogle Scholar
  29. 29.
    Black, F. L., Hierholzer, W. J., Pineiro, F. Dep., Evans, A. S., Woodhall, J. P., Opton, E. M., Emmons, J. E., West, B. S., Edsall, G., Downs, W. G., and Wallace, G. D., Evidence for persistence of infections agents in isolated human populations, Am. J. Epidemiol. 100: 230–250 (1974).PubMedGoogle Scholar
  30. 30.
    Black, R. E., Merson, M. H., Rahman, A. S. M., Yunus, M., Alim, A. R. M., Huq, I., Yolken, R. H., and Curlin, G. T., A two-year study of bacterial, viral and parasitic agents associated with diarrhea in rural Bangladesh, J. Infect. Dis. 142: 660–664 (1980).PubMedCrossRefGoogle Scholar
  31. 31.
    Black, R. E., Epidemiology of travelers’ diarrhea and relative importance of various pathogens, Rev. Infect. Dis. 12 (Suppl. 1): S73 - S79 (1990).PubMedCrossRefGoogle Scholar
  32. 32.
    Blattner, W. A., Biggar, R. J., Weiss, S. H., Melbye, M., and Goedert, J. J., Epidemiology of human T-Iymphotropic virus type III and the risk of the acquired immunodeficiency syndrome, Ann. Inter. Med. 103: 665–670 (1985).CrossRefGoogle Scholar
  33. 33.
    Blower, S. M., Anderson, R. M., and Wallace, P., Loglinear models, sexual behavior and HIV: Epidemiological implications of heterosexual transmission, J. Acquir. Immune Defic. Syndr. 3: 763–772 (1990).PubMedGoogle Scholar
  34. 34.
    Blumberg, B. S., Alter, H. J., and Visnick, S., A “new” antigen in leukemia sera, J.A.M.A. 191: 541–546 (1965).PubMedCrossRefGoogle Scholar
  35. 35.
    Bourgault, I., Gomez, A., Gomrad, E., Picard, F., and Levy, J. P., A virus-specific CD4+ cell-mediated cytolytic activity revealed by CD8+ cell elimination regularly develops in uncloned human antiviral cell lines, J. Immunol. 142: 252–256 (1989).PubMedGoogle Scholar
  36. 36.
    Bradley, D. W., Hepatitis E: Epidemiology, aetiology and molecular biology, Rev. Med. Virol. 2: 19–28 (1992).CrossRefGoogle Scholar
  37. 37.
    Brandt, C. D., Kim, H. W., Rodriguez, W. J., Arrobio, J. O., Jeffries, B. C., Stallings, E. P., Lewis, C., Miles, A. J., Chanock, R. M., Kapikian, A. Z., and Parrott, R. H., Pediatric viral gastroenteritis during eight years of study, J. Clin. Microbiol. 18: 71–78 (1983).PubMedGoogle Scholar
  38. 37a.
    Brancon, B. M., Early intervention for persons infected with human immunodeficiency virus, Clin. Infect. Dis. 20 (Suppl.): S3 - S22 (1995).CrossRefGoogle Scholar
  39. 38.
    Brody, J. A., and Detels, R., Subacute sclerosing panencephalitis: A zoonosis following aberrant measles, Lancet 2: 500–501 (1970).PubMedCrossRefGoogle Scholar
  40. 39.
    Brookmayer, R., and Gail, M. H., AIDS Epidemiology: A Quantitative Approach, Oxford University Press, New York, 1994.Google Scholar
  41. 40.
    Buchbinder, S. E, Katz, M. H., Hessol, N. A., O’Malley, P. M., and Holmberg, S. D., Long-term HIV-1 infection without immunologic progression, AIDS 8: 1123–1128 (1994).PubMedCrossRefGoogle Scholar
  42. 41.
    Byrne, E. B., Evans, A. S., Fonts, D. W., and Israel, H. L., A seroepidemiological study of Epstein-Barr virus and other viral antigens in sarcoidosis, Am. J. Epidemiol. 97: 335–363 (1973).Google Scholar
  43. 42.
    Carpenter, C. B., and David, J., Immunology-histocompatibility antigens and immune response genes, in: Scientific American Medicine (E. Rubenstein and D. D. Lederman, eds.), pp. 1–10, Scientific American, New York, 1991.Google Scholar
  44. 43.
    Centers for Disease Control and Prevention, Guidelines for investigating clusters of health events, Morbid. Mortal. Week. Rep. 39 (No. RR-11): 1–23 (1990).Google Scholar
  45. 44.
    Centers for Disease Control and Prevention, Immunization Practices Advisory Committee, Update on Adult Immunization: Recommendations of the Immunization Practices Advisory Committee (ACIP), Morbid. Mortal. Week. Rep. 40 (No. RR-12): 1–94 (1991).Google Scholar
  46. 45.
    Centers for Disease Control and Prevention, Update: International task force for disease eradication, 1990 and 1991, Morbid. Mortal. Week. Rep. 40: 40–42 (1992).Google Scholar
  47. 46.
    Centers for Disease Control and Prevention, Summary of notifiable diseases, United States, 1991, Morbid. Mortal. Week. Rep. 40: 1–64 (1992).Google Scholar
  48. 47.
    Centers for Disease Control and Prevention, Standards for pediatric immunization practices, Morbid. Mortal. Week. Rep. 42 (No. RR-5): 1–13 (1991).Google Scholar
  49. 48.
    Centers for Disease Control and Prevention, Hepatitis E among U.S. travelers, Morbid. Mortal. Week. Rep. 42: 1–4 (1993).Google Scholar
  50. 49.
    Centers for Disease Control and Prevention, Recommendations of the Advisory Committee on Immunization Practices (ACIP): Use of vaccines and immune globulins in persons with altered immunocompetence, Morbid. Mortal. Week. Rep. 42 (No. RR-16): 1–18 (1993).Google Scholar
  51. 50.
    Centers for Disease Control and Prevention, Standards for pediatric immunization practices. Recommended by the National Vaccine Advisory Committee, Morbid. Mortal. Week. Rep. 42 (No. RR-5): 1–13 (1993).Google Scholar
  52. 51.
    Centers for Disease Control and Prevention, Recommendations of the International Task Force for Disease Eradication, 1990 and 1991, Morbid. Mortal. Week. Rep. 42 (No. RR-16) (1993).Google Scholar
  53. 52.
    Centers for Disease Control and Prevention, Summary Of notifiable diseases, United States, 1993, Morbid. Mortal. Week. Rep. 42: 1–73 (1994).Google Scholar
  54. 53.
    Centers for Disease Control and Prevention, Addressing emerging infectious disease threats: A prevention strategy for the United States. Atlanta, Georgia: U.S. Department of Health and Human Services, Public Health Service, 1994.Google Scholar
  55. 54.
    Centers for Disease Control and Prevention, General recommendations on immunization, Morbid. Mortal. Week. Rep. 43: 1–38 (1994).Google Scholar
  56. 55.
    Centers for Disease Control and Prevention, Hantavirus pulmonary syndrome-northeastern United States, 1994, Morbid. Mortal. Week. Rep. 43: 548–556 (1994).Google Scholar
  57. 56.
    Centers for Disease Control and Prevention, Dengue fever among U.S. military personnel-Haiti, September-November 1994, Morbid. Mortal. Week. Rep. 43: 845–848 (1994).Google Scholar
  58. 57.
    Centers for Disease Control and Prevention, Bolivian hemorrhagic fever-El Beni department, Bolivia, 1994, Morbid. Mortal. Week. Rep. 43: 943–946 (1994).Google Scholar
  59. 58.
    Centers for Disease Control and Prevention, Recommended childhood immunization schedule-United States, January 1995, Morbid. Mortal. Week. Rep. 43: 959–960 (1995).Google Scholar
  60. 59.
    Centers for Disease Control and Prevention, Physician vaccination referral practices and vaccines for children-New York, 1994, Morbid. Mortal. Week. Rep. 44: 3–6 (1995).Google Scholar
  61. 60.
    Chaisson, R. E., and Griffin, D. E., Progressive multifocal leukoencephalopathy in AIDS, J.A.M.A. 264: 79–82 (1990).PubMedCrossRefGoogle Scholar
  62. 61.
    Chan, C. K., Mueller, N., Evans, A., Harris, N. L., CoMstock, G. W., Jellum, E., Magnus, K., Orentreich, N., Polk, B. F., and Vogelman, J., Epstein-Barr virus antibody patterns preceding the diagnosis of nasopharyngeal carcinoma, Cancer Causes Control 2: 125–131 (1991).PubMedCrossRefGoogle Scholar
  63. 62.
    Chang, Y., Cesarman, E., Pessin, M. S., Lee, E, Culpepper, J., Knowles, D. M., and Moore, P. S., Identification of herpesvirus-like DNA sequences in AIDS-associated Kaposi’s sarcoma, Science 266: 1865–1869 (1994).PubMedCrossRefGoogle Scholar
  64. 63.
    Chanock, R., Chambon, L., Chang, W., Gerreira, F. G., Gharpure, P., Grant, L., Hatel, J., Inman, I., ’Calla, S., Lim, K., Madalengoitia, J., Spense, L., Teng, R, and Ferreira, W., WHO respiratory survey in children: A serological study, Bull. WHO 37: 363–369 (1967).PubMedGoogle Scholar
  65. 64.
    Chanock, R. M., Parrott, R. H., Kapikian, A. Z., Kim, H. W., and Brandt, C. D., Possible role of immunological factors in pathogenesis of RS virus lower respiratory tract disease, Perspect. Viral. 6: 125–135 (1968).Google Scholar
  66. 65.
    Cherry, J. D., Contemporary infectious exanthems, Clin. Infect. Dis. 16: 199–207 (1993).PubMedCrossRefGoogle Scholar
  67. 66.
    Choi, K., and Thacker, S. B., Improved accuracy and specificity of forecasting deaths attributed to pneumonia and influenza, J. Infect. Dis. 144: 606–608 (1981).PubMedCrossRefGoogle Scholar
  68. 67.
    Cohen, J., Special news report: The Duesberg phenomenon, Science 266: 1642–1649 (1994).PubMedCrossRefGoogle Scholar
  69. 68.
    Comstock, G. W., Evaluating vaccination effectiveness and vaccine efficacy by means of case-control studies, Epidemiol. Rev. 16: 77–89 (1994).PubMedGoogle Scholar
  70. 69.
    Cone, R. W., Hackman, R. C., Huang, M-L. W., Bowden, R. A., Meyers, J. D., Metcalf, M., Zeh, J., Ashley, R., and Corey, L., Human herpesvirus 6 in lung tissue from patients with pneumonitis after bone marrow transplantation, N. Engl. J. Med. 329: 156–161 (1993).PubMedCrossRefGoogle Scholar
  71. 70.
    Connolly, J. H., Allen, I V., Hurwitz, L. J., and Millar, J. H. D., Measles-virus antibody and antigen in subacute sclerosing panencephalitis, Lancet 1: 542–544 (1967).PubMedCrossRefGoogle Scholar
  72. 71.
    Connor, E. M., Sperling, R. S., Gelber, R., Kiselev, P, Scott, G., O’Sullivan, M. J., Vandyke, R., Bey, M., Shearer, W., Jacobson, R. L.; Jimenez, E., O’Neill, E., Bazin, B., Delfraissy, J.-E, Culnane, M., Coombs, R., Elkins, M., Moye, J., Stratton, P., and Balsley, J., Reduction of maternal-infant transmission of human immunodeficiency virus type 1 with zidovudine treatment, N. Engl. J. Med. 331: 1173–1180 (1994).Google Scholar
  73. 72.
    Cooper, D. A., Gold, J., Maclean, R, DoNovan, B., Finlayson, R., Barnes, T. G., Michelmore, H. M., Brooke, P., and Penny, R., For The Sydney AIDS Study Group, Acute AIDS retrovirus infection. Definition of a clinical illness associated with seroconversion, Lancet 1: 537–540 (1985).Google Scholar
  74. 73.
    Corey, L., Genital herpes, in: Sexually Transmitted Disease (K. K. Holmes, P-A. Mardh, P. F. Sparling, and R J. Wiesner, eds.), pp. 391–414, McGraw-Hill, New York, 1990.Google Scholar
  75. 74.
    Corriel, L. L., Clinical syndromes in children caused by respiratory infection, Med. Clin. North Am. 51: 819–830 (1967).Google Scholar
  76. 75.
    Cubit, W. D., The candidate caliciviruses, CIBA Found. Symp. 128: 126–143 (1987).Google Scholar
  77. 76.
    Davidson, G. P., Bishop, R. E, Townley, R. R. W., Holmes, I. H., and Ruck, B. J., Importance of a new virus in acute sporadic enteritis in children, Lancet 1: 242–245 (1975).PubMedCrossRefGoogle Scholar
  78. 77.
    DE The, G., Geser, A., Day, N. E., Tubei, R M., Williams, E. H., Bier, D. P., Smith, D. G., Dean, A. G., Bornhamm, G. W., Feorino, P., and Henle, W., Epidemiological evidence for causal relationship between Epstein-Barr virus and Burkitt’s lymphoma from Ugandan prospective study, Nature 274: 756–761 (1978).CrossRefGoogle Scholar
  79. 78.
    Dobbins, J. G., and Stewart, J. A., Surveillance of congenital cytomegalovirus disease, 1990–1991, Morbid. Mortal. Week. Rep. 41 (1992).Google Scholar
  80. 79.
    Dour, R., Antiviral chemotherapy and chemoprophylaxis, Science 227: 1296–1303 (1985).CrossRefGoogle Scholar
  81. 80.
    Dougherty, W. J., and Altman, R., Viral hepatitis in New Jersey 1960–1961, Am. J. Med. 32: 704–716 (1962).PubMedCrossRefGoogle Scholar
  82. 81.
    Douglas, R. G., Influenza in man, in: The Influenza Viruses and Influenza (E. D Kilbourne, ED.), pp. 395–447, Academic Press, New York, 1975.Google Scholar
  83. 82.
    Douglas, R. G., Betts, R. E, Hruska, J. F. and Hall, C. B., Epidemiology of nosocomial viral infections, in: Seminars in Infectious Disease, Vol. II (L. Weinstein and B. H. Fields, eds.), pp. 98–144, Stratton Intercontinental Medical Book Corp., New York, 1979.Google Scholar
  84. 83.
    Duchin, J. S., Koster, E T., Peters, C. J., Simpson, G. L., Tempest, B., Zaki, S. R., Ksiazek, T. T., Rollin, P. E., Nichols, S., Umland, E. T., Moolenaan, R. L., Reef, S. E., Nolte, K. B., Gallerher, M. M., Butler, J. C., Breiman, R. E, and The Hantavirus Study Group, Hantavirus pulmonary syndrome: A clinical description of 17 patients with a newly recognized disease, N. Engl. J. Med. 330: 949–955 (1994).Google Scholar
  85. 84.
    Duesberg, R, AIDS epidemiology. Inconsistencies with human immunodeficiency virus and with infectious disease, Proc. Natl. Acad. Sci. USA 88: 1575–1579 (1991).PubMedCrossRefGoogle Scholar
  86. 85.
    Duesberg, P., HIV is not the cause of AIDS, Science 241: 514–516 (1988).PubMedCrossRefGoogle Scholar
  87. 86.
    Dwyer, D. M., Strickler, H., Goodman, R. A., and Armenian, H. K., Use of case-control studies in outbreak investigations, Epidemiol. Rev. 16: 109–123 (1994).PubMedGoogle Scholar
  88. 87.
    Editorial, Rotaviruses of man and animals, Lancet 1: 257–259 (1975).Google Scholar
  89. 88.
    Elveback, L. R., Ackerman, E., Young, G., and Fox, J. R, A stochastic model for competition between viral agents in the presence of interference. 1. Live virus vaccine in randomly mixing population, model III, Am. J. Epidemiol. 87: 373–384 (1968).PubMedGoogle Scholar
  90. 89.
    Englund, J. A., Sullivan, C. A., Jordan, M. C., Dehner, L. R, Vercellotti, G. M., and Balfour, H. H., JR., Respiratory syncytial virus infection in immunocompromised adults, Ann. Intern. Med. 109: 203–208 (1988).PubMedCrossRefGoogle Scholar
  91. 90.
    Evans, A. S., Clinical syndromes in adults caused by respiratory infection, Med. Clin. North Am. 5: 803–818 (1967).Google Scholar
  92. 91.
    Evans, A. S., The spectrum of infections with Epstein-Barr virus: A hypothesis, J. Infect. Dis. 124: 330–337 (1971).PubMedCrossRefGoogle Scholar
  93. 92.
    Evans, A. S., Clinical syndromes associated with EB virus infection, Adv. Intern. Med. 18: 77–93 (1972).PubMedGoogle Scholar
  94. 93.
    Evans, A. S., Diagnosis and prevention of common respiratory infection, Hosp. Pract. 10: 31–41 (1974).Google Scholar
  95. 94.
    Evans, A. S., New discoveries in infectious mononucleosis, Mod. Med. 42: 18–24 (1974).Google Scholar
  96. 95.
    Evans, A. S., EB virus, infectious mononucleosis and cancer: The closing of the web, Yale J. Biol. Med. 47: 113–122 (1974).PubMedGoogle Scholar
  97. 96.
    Evans, A. S., Causation and disease: The Heenle-Koch postulates revisited, Yale J. Biol. Med. 49: 175–195 (1976).PubMedGoogle Scholar
  98. 97.
    Evans, A. S., Limitations of Koch’s postulates, Lancet 2: 1277–1278 (1977).PubMedCrossRefGoogle Scholar
  99. 98.
    Evans, A. S., Causation and disease: A chronological journey, Am. J. Epidemiol. 108: 249–258 (1978).PubMedGoogle Scholar
  100. 99.
    Evans, A. S., AIDS: The alternative view, Lancet 339: 1547 (1992).PubMedCrossRefGoogle Scholar
  101. 100.
    Evans, A. S., Criteria for control of infectious diseases using poliomyelitis as an example, Prog. Med. Virol. 29: 141–165 (1984).PubMedGoogle Scholar
  102. 101.
    Evans, A. S., The eradication of communicable diseases: Myth or reality ? Am. J. Epidemiol. 122: 199–207 (1985).PubMedGoogle Scholar
  103. 102.
    Evans, A. S., The clinical illness promotion factor. A third ingredient, Yale J. Biol. Med. 55: 193–199 (1985).Google Scholar
  104. 103.
    Evans, A. S., Does HIV cause AIDS? An historical perspective, J. Acquir. Immune Dis. Syndr. 2: 107–113 (1989).Google Scholar
  105. 104.
    Evwxs, A. S., Epstein-Barr vaccine: Use in infectious mononucleosis, in: Epstein-Barr Virus and Associated Diseases (T. Tursz, J. S. Pagano, D. V. Ablashi, G. DE The, G. Lenoir, and G. Pearson, eds.), pp. 593–598, Collogue/Inserm, John Lib-bey, Eurotext, London, 1993.Google Scholar
  106. 105.
    Evans, A. S., Causation and Disease. A Chronological Journey, Plenum Press, New York, 1993.CrossRefGoogle Scholar
  107. 106.
    Evans, A. S., and Campus, L. E., Acute respiratory disease in students at the University of the Philippines, Bull. WHO 45: 103–112 (1971).PubMedGoogle Scholar
  108. 107.
    Evans, A. S., Campus, L. E., Dallessio, D. A., and Dick, E. C., Acute respiratory disease in University of the Philippines and University of Wisconsin students: A comparative study, Bull. WHO 36: 397–407 (1967).Google Scholar
  109. 108.
    Evans, A. S., and Comstock, G., Presence of elevated antibody titres to Epstein-Barr virus before Hodgkin’s disease, Lancet 1: 1182–1186 (1981).Google Scholar
  110. 109.
    Evans, A. S., Cox, E, Nankervis, G., Opton, E., Shope, R., Wells, A. V., and West, B., A health and seroepidemiological survey of a community in Barbados, Int. J. Epidemiol. 3: 267–275 (1974).CrossRefGoogle Scholar
  111. 110.
    Evans, A. S., and Gutensohn, N., A population-based case-control study of EBV and other viral antibodies among persons with Hodgkin’s disease and their siblings, Int. J. Cancer 34: 149–157 (1984).PubMedCrossRefGoogle Scholar
  112. 111.
    Evans, A. S., Kirchhoff, L. V., Panutti, C. S., Carvalho, R. P. S., and Mcclelland, K. A., Case-control study of Hodgkin’s disease in Brazil. II. Seroepidemiologic studies in cases and family members, Am. J. Epidemiol. 122: 609–618 (1980).Google Scholar
  113. 112.
    Evans, A. S., and Mueller, N., Viruses and cancer. Causal associations, Ann. Epidemiol. 1: 71–92 (1989).CrossRefGoogle Scholar
  114. 113.
    Evans, A. S., and Mueller, N. E., The past is prologue: Use of serum banks in cancer research, Cancer Res. 52: 5557s - 5560s (1992).PubMedGoogle Scholar
  115. 114.
    Evans, A. S., Niederman, J. C., and Mccollum, R. W., Seroepidemiologic studies of infectious mononucleosis with EB virus, N. Engl. J. Med. 279: 1123–1127 (1968).CrossRefGoogle Scholar
  116. 115.
    Evans, A. S., Niederman, J. C., and Sawyer, R. N., Prospective studies of a group of Yale University freshmen. II. Occurrence of acute respiratory infections and rubella, J. Infect. Dis. 123: 271–278 (1971).Google Scholar
  117. 116.
    Evans, A. S., Shepard, K. A., and Richards, V. A., ABO blood groups and viral diseases, Yale J. Biol. Med. 45: 81–92 (1972).PubMedGoogle Scholar
  118. 117.
    Fauci, A. S., CD4+ T lymphocytopenia without HIV infection-no lights, no camera, just facts, N. Engl. J. Med. 328: 429–431 (1993).PubMedCrossRefGoogle Scholar
  119. 118.
    Fenner, E J., and White, D. O., Medical Virology, 3rd ed., Academic Press, Orlando, FL, 1990.Google Scholar
  120. 119.
    Fields, B. N., Knipe, D. M., Chanock, R. M., Melnick, J. L., Roizman, B., and Shope, R. E. (EDs.), Field’s Virology, 2nd ed., Raven Press, New York, 1990.Google Scholar
  121. 119a.
    Finkelstein, D. M., and Schoenfeld, D. A., AIDS Clinical Trials, John Wiley, New York, 1995.Google Scholar
  122. 120.
    Fox, J. P., and Hall, C. B., Viruses in Families: Surveillance of Families as a Key to Epidemiology of Virus Infections, Psg Publishing, Littleton, MA, 1980.Google Scholar
  123. 121.
    Fox, R., Eldred, L. J., Fucxs, E. J., Kaslow, R. A., Visscher, B. R., HO, M., Phair, J. P., and Polk, B. F., Clinical manifestations of acute infection with human immunodeficiency virus in a cohort of gay men, AIDS 1: 35–38 (1987).PubMedGoogle Scholar
  124. 122.
    Gail, M. H., and Brookmeyer, R., Methods for projecting the course of acquired immunodeficiency syndrome epidemic, J. Natl. Cancer Inst. 80: 900–911 (1988).PubMedCrossRefGoogle Scholar
  125. 123.
    Gerberding, J., Is antiretroviral treatment after percutaneous HIV exposure justified? Ann. Intern. Med. 188: 979–980 (1993).CrossRefGoogle Scholar
  126. 124.
    Gerone, P. J., Couch, R. B., Keefer, G. V., Douglas, R. G., Derrenbacher, E. B., and Knight, V., Assessment of experimental and natural viral aerosols, Bacteriol. Rev. 30:576–584, 584–588 (1966).Google Scholar
  127. 125.
    Glezen, W., and Denny, E, Epidemiology of acute lower respiratory disease in children, N. Engl. J. Med. 288: 498–505 (1973).PubMedCrossRefGoogle Scholar
  128. 126.
    Goedert, J. J., Kessler, C. M., Aledort, L. M., Biggar, R. J., Andes, W. A., White, G. C., Drummond, J. E., Vaidya, K., Mann, D. L., Eyster, M. E., Ragni, M., Lederman, M. M., Cohen, A. R., Bray, G. L., Rosenberg, P. S., Friedman, R. M., Hilgartner, M. W., Blattner, W. A., Kroner, B., and Gail, M. H., A prospective study of human immunodeficiency virus type 1 infection and the development of AIDS in subjects with hemophilia, N. Engl. J. Med. 321: 1141–1148 (1989).PubMedCrossRefGoogle Scholar
  129. 127.
    Gonzalez-Scarano, F., and Tyler, K. L., Molecular pathogenesis of neurotropic viral infections, Ann. Neurol. 22: 565–574 (1987).Google Scholar
  130. 128.
    Gregg, M. B., The principles of epidemic investigation, in: Oxford Textbook of Public Health, 2nd ed. (W. W. Holland, R. Detels, and G. E. Knox), pp. 284–297, Oxford University Press, Oxford, 1991.Google Scholar
  131. 129.
    Griffin, D. E., Alphivirus pathogenesis and immunity, in: The Togaviridae and Flaviviridae (S. Schlesinger and M. J. Schlesinger, eds.), pp. 209–249, Plenum Press, New York, 1986.CrossRefGoogle Scholar
  132. 130.
    Guidry, G. G., Black-Payne, C. A., Payne, D. K., Jamison, R. M., George, R. B., and Bocchini, J. A., Respiratory syncytial virus infection among intubated adults in a university medical intensive care unit, Chest 100: 1377–1384 (1991).PubMedCrossRefGoogle Scholar
  133. 131.
    Gurwith, M. J., and Williams, T. W., Gastroenteritis in children: A two-year review in Manitoba. I. Etiology, J. Infect. Dis. 136: 239–247 (1977).PubMedCrossRefGoogle Scholar
  134. 132.
    Gwaltney, J. M., and Hendley, J. O., Rhinovirus transmission: One if by air, two if by hand, Am. J. Epidemiol. 107: 357–361 (1978).PubMedGoogle Scholar
  135. 133.
    Haber, M., Longini, I. M., and Halloran, M. E., Estimation of vaccine efficacy in outbreaks of acute infectious diseases, Stat. Med. 10: 1773–1784 (1991).CrossRefGoogle Scholar
  136. 134.
    Hall, C. B., Douglas, R. G., Geinan, J. M., and Messner, M. K., Nosocomial respiratory syncytial infections, N. Engl. J. Med. 293: 1343–1346 (1975).PubMedCrossRefGoogle Scholar
  137. 135.
    Hall, W. J., Hall, C. B., and Speers, D. M., Respiratory syncytial virus infections in adults, Ann. Intern. Med. 88: 203–205 (1978).PubMedCrossRefGoogle Scholar
  138. 136.
    Halloran, M. E., Cochi, S. L., Lieu, T. A., Wharton, M., and Fehrs, L., Theoretical epidemiologic and morbidity effects of routine varicella immunization of preschool children in the United States, Am. J. Epidemiol. 140: 81–104 (1994).Google Scholar
  139. 137.
    Henderson, D. K., Fahey, B. J., Willy, M., Schmitt, J. M., Carey, K., Koziol, D. E., Lane, H. C., Fedio, J., and Saah, A. J., Risk for occupational transmission of human immunodeficiency virus type 1 (HIV-1) associated with clinical exposures: A prospective evaluation, Ann. Intern. Med. 113: 740–746 (1990).PubMedCrossRefGoogle Scholar
  140. 138.
    Hendley, J. O., Wenzel, R. P., and Gwaltney, J. M., Transmission of rhinovirus colds by self-induction, N. Engl. J. Med. 288: 1361–1364 (1974).CrossRefGoogle Scholar
  141. 139.
    Henle, G., Henle, W., and Diehl, V, Relation of Burkitt’s tumor-associated herpes-type virus to infectious mononucleosis, Proc. Natl. Acad. Sci. USA 59: 94–101 (1968).PubMedCrossRefGoogle Scholar
  142. 140.
    Hersh, B. S., Markowitz, L. E., Hoffman, R. B., Hoff, D. R., Doran, M. J., Fleishman, J. C., Preblud, S. R., and Orenstein, W. A., A measles outbreak at a college with a prematriculation immunization requirement, Am. J. Public Health 81: 360–364 (1991).PubMedCrossRefGoogle Scholar
  143. 141.
    Hessol, N. A., Koblin, B. A., Van Griensven, G. J. P., Bachetn, P., Liu, J. Y., Stevens, C. E., Coutinho, R. A., Buchbinder, S. E, and Katz, M. H., Progression of human immunodeficiency virus type 1 (HIV-1) infection among homosexual men in hepatitis B vaccine trial cohorts in Amsterdam, New York City, and San Francisco, 1978–1991, Am. J. Epidemiol. 139: 1077–1087 (1994).PubMedGoogle Scholar
  144. 142.
    Hinman, A. R., Orenstein, W. A., and Mortimer, E. A., When, where, and how do immunizations fail? Ann. Epidemiol. 2: 805–812 (1992).PubMedCrossRefGoogle Scholar
  145. 143.
    HO, M.-S., Yang, C.-S., Chen, P.-J., and Mau, Y-C., Intrafamilial transmission of hepatitis C virus, J. Clin. Microbiol. 32: 2824–2826 (1994).PubMedGoogle Scholar
  146. 144.
    Hogan, T. F., Padgett, B. L., and Walker, D. L., Human polyomaviruses, in: Textbook of Human Virology (R. B. Belshe, ED.), pp. 970–1000, Mosby-Yearbook, St. Louis, 1991.Google Scholar
  147. 145.
    Holmberg, S. D., Stewart, J. A., and Gerber, A. R., Prior herpes simplex virus type 2 infection as a risk factor for HIV infection, J.A.M.A. 259: 1048–1050 (1988).PubMedCrossRefGoogle Scholar
  148. 146.
    Horstmann, D. M., Liebhaber, H., Leeouvier, G. L., Rosenberg, D. A., and Halstead, S. B., Rubella: Reinfection of vaccinated and naturally immune persons exposed in an epidemic, N. Engl. J. Med. 283: 771–778 (1970).PubMedCrossRefGoogle Scholar
  149. 147.
    Huebner, R. J., The virologist’s dilemma, Ann. N. Y. Acad. Sci. 67: 430–442 (1957).PubMedCrossRefGoogle Scholar
  150. 148.
    Hurwitz, E. S., Barrett, M. J., Bregman, D., Gunn, W. J., Schonberger, L. B., Fairweather, W. R., Drage, J. S., Lamontagne, J. R., Kaslow, R. A., Burlington, D. B., Qunnan, G. V., Parker, R. A., Phillips, K., Pinsky, P., Dayton, D., and Dowdle, W. R., Public Health Service study of Reye’s syndrome and medications: Report of the pilot phase, N. Engl. J. Med. 313: 849–857 (1985).PubMedCrossRefGoogle Scholar
  151. 149.
    Ing, D., Glass, R. I., Lebaron, C. W., and Lew, J. F., Laboratory-based surveillance for rotavirus, United States, January 1989-May 1991, Morbid. Mortal. Week. Rep. 41 (SS-3): 47–56 (1992).Google Scholar
  152. 150.
    Iwarson, S., The main five types of viral hepatitis: An alphabetical update, Scand. J. Infect. Dis. 24: 129–135 (1992).PubMedCrossRefGoogle Scholar
  153. 151.
    Jaffe, H. W., Choi, K., Thomas, E, Haverkos, H. N., Auerbach, D. M., Guinan, M. E., Rogers, M. F., Spira, T. J., Darrow, W. W., Kramer, M. A., Friedman-Kien, A. E., Laubenstein, L. J., Marmor, M., Safai, B., Dritz, S. K., Crispi, S. J., Fannin, S. L., Orkwis, J. E, Kelter, A., Rushing, W. R., Thacker, S. B., and Curran, J., National case-control study of Kaposi’s sarcoma and Pneumocystic carinii pneumonia in homosexual men. Part 1: Epidemiologic results, Ann. Intern Med. 99: 145–151 (1983).PubMedCrossRefGoogle Scholar
  154. 152.
    Jenison, S. A., Lemon, S. M., Baker, L. N., and Newbold, J. E., Quantitative analysis of hepatitis B virus DNA in saliva and semen of chronically infected homosexual men, J. Infect. Dis. 156: 299–307 (1987).PubMedCrossRefGoogle Scholar
  155. 153.
    Johnson, R. E., Nahmias, A. J., Magder, L. S., Lee, F. K., Brooks, C. A., and Snowden, C. B., A seroepidemiologic survey of the prevalence of herpes simplex virus type 2 infection in the United States, N. Engl. J. Med. 321: 7–12 (1989).PubMedCrossRefGoogle Scholar
  156. 154.
    Johnson, T. R., Viral Infections of the Nervous System, Raven Press, New York, 1982.Google Scholar
  157. 155.
    Johnson, R. T., Persistent viral infections and demyelinating disease, in: Viruses and Demyelinating Diseases (C. A. Mims, M. L. Cuzner, and R. E. Kelly, eds.), pp. 7–19, Academic Press, New York, 1983.Google Scholar
  158. 156.
    Johnson, R. T., and Mims, C. A., Pathogenesis of viral infections of the nervous system, N. Engl. J. Med. 278: 23–30, 84–92 (1968).CrossRefGoogle Scholar
  159. 157.
    Johnson, R. T., Prion diseases, N. Engl. J. Med. 326: 486–487 (1992).PubMedCrossRefGoogle Scholar
  160. 158.
    Johnson, R. T., Questions and prospects related to HIV-1 and the brain, Res. Publ. Assoc. Res. Nerv. Ment. Dis. 72: 311–323 (1994).PubMedGoogle Scholar
  161. 159.
    Johnson, R. T., The pathogenesis of acute viral encephalitis and postinfectious encephalomyelitis, J. Infect. Dis. 155: 359–364 (1987).PubMedCrossRefGoogle Scholar
  162. 160.
    Jordan, M. C., Rousseau, W. E., Noble, G. R., Stewart, J. A., and Chin, T. D. Y., Association of cervical cytomegaloviruses with venereal disease, N. Engl. J. Med. 288: 932–934 (1973).PubMedCrossRefGoogle Scholar
  163. 161.
    Kapikian, A. Z., Kim, H. W., Wyatt, R. G., Cline, W. L., Arrobio, J. O., Brandt, C. D., Rodriguez, W. J., Sack, D. A., Chanock, R. M., and Parrott, R. H., Human reovirus-like agent as the major pathogen associated with “winter gastroenteritis” in hospitalized infants and young children, N. Engl. J. Med. 294: 965–972 (1976).PubMedCrossRefGoogle Scholar
  164. 162.
    Kapikian, A. Z., Wyatt, R. G., Dolin, R., Thornhill, T. S., Kalica, A. R., and Chanock, R. M., Visualization by immune electron microscopy of a 27-nm particle associated with acute infectious non-bacterial gastroenteritis, J. Virol. 10: 1075–1081 (1972).PubMedGoogle Scholar
  165. 163.
    Kasl, S. V, Evans, A. S., and Niederman, J. C., Psychosocial risk factors in the development of infectious mononucleosis, Psychosom. Med. 41: 445–446 (1979).PubMedGoogle Scholar
  166. 164.
    Kaslow, R. A., Ostrow, D. G., Detels, R., Phair, J. P., Polk, B. E, and Rinaldo, C. R., The Multicenter AIDS Cohort Study: Rationale, organization, and selected characteristics of the participants, Am. J. Epidemiol. 126: 310–318 (1987).PubMedCrossRefGoogle Scholar
  167. 165.
    Kaslow, R. A., Duquesnoy, R., Vanraden, M., Kingsley, L., Marrari, M., Friedman, H., SU, S., Saah, A. J., Detels, R., Phair, J., and Rinaldo, C., Al, Cw7, B8, DR3 Hla combination associated with rapid decline of T-helper lymphocytes in HIV-1 infection, Lancet 335: 927–930 (1990).PubMedCrossRefGoogle Scholar
  168. 166.
    Kaslow, R. A., Carrington, M., Apple, R., Park, L., Munoz, A., Saah, A. J., Goedert, J. J., Winkler, C., Obrien, S. J., Rinaldo, C., Detels, R., Blattner, W., Phair, J., Erlich, H., and Mann, D. L., Influence of combinations of human major histocompatibility complex genes on the course of HIV-1 infection, Nature Med. 2: 405–411 (1996).PubMedCrossRefGoogle Scholar
  169. 167.
    Keet, I. P. M., Lee, F. K., Vangriensven, G. J. P., Lange, J. M. A., Nahmias, A., and Coutinho, R. A., Herpes simplex virus type 2 and other genital ulcerative infections as a risk factor for HIV-1 acquisition, Genitourin. Med. 66: 330–333 (1990).PubMedGoogle Scholar
  170. 168.
    Keet, I. P. M., Krijnen, P., Koot, M. Lange, J. M. A., Miedema, F., Goudsmit, J., and Coutinho, R. A., Predictors of rapid progression to AIDS in HIV-1 seroconverters, AIDS 7: 51–57 (1993).PubMedCrossRefGoogle Scholar
  171. 169.
    Kelsey, J. L., Thompson, W. D., and Evans, A. S., Methods in Observational Epidemiology, Oxford University Press, New York, 1986.Google Scholar
  172. 170.
    Kiecolt-Glaser, J. K., Dura, J. R., Speicher, C. E., Trask, O. J., and Glaser, R., Spousal caregivers of dementia victims: Longitudinal changes in immunity and health, Psychosom. Med. 53: 345–362 (1991).Google Scholar
  173. 171.
    Kingsley, L. A., Zhou, S. Y. J., Bacellar, H., Rinaldo, C. R., Chmiel, J., Detels, R., Shah, A., Vanraden, M., Ho, M., and Munoz, A., Temporal trends in human immunodeficiency virus type 1 seroconversion 1984–1989. A report from the Multicenter AIDS Cohort Study (Macs), Am. J. Epidemiol. 134 (4): 331–339 (1991).PubMedGoogle Scholar
  174. 172.
    Kinney, J. S., Anderson, L. J., Farrar, J., Strikas, R. A., Kumar, M. L., Kliegman, R. M., Sever, J. L., Hurwitz, E. S., and Sikes, R. K., Risk of adverse outcomes of pregnancy after human parvovirus B19 infection, J. Infect. Dis. 157: 663–667 (1988).PubMedCrossRefGoogle Scholar
  175. 173.
    Klein, J. O., Diagnostic lung puncture in the pneumonias of infants and children, Pediatrics 44: 486–492 (1969).PubMedGoogle Scholar
  176. 174.
    Klein, M. R., Keet, I. P. M., Damaro, J., Bende, R. J., Hekman, A., Mesman, B., Koot, M., Dewaal, L. P., Coutinho, R., and Miedema, F., Associations between Hla frequencies and pathogenic features of human immunodeficiency virus type 1 infection of seroconverters from the Amsterdam cohort of homosexual men, J. Infect. Dis. 169: 1244–1249 (1994).PubMedCrossRefGoogle Scholar
  177. 175.
    Klitzman, R. L., Alpers, M. R, and Gajdusek, D. C., The natural incubation period of kuru and episodes of transmission in three clusters of patients, Neuroepidemiology 3: 3–20 (1984).CrossRefGoogle Scholar
  178. 176.
    Kloene, W., Bang, F. B., Chakraborty, S. M., Cooper, M. R., Kulemann, H., Ota, M., and Shah, K. V., A two-year respiratory virus survey in four villages in West Bengal, India, Am. J. Epidemiol. 92: 307–320 (1970).PubMedGoogle Scholar
  179. 177.
    Knight, V., (ED.), Viral and Mycoplasma Infections of the Respiratory Tract, Lea & Febiger, Philadelphia, 1973.Google Scholar
  180. 178.
    Koch, R., Uber bacteriologische Forschung, Int. Med. Cong. Berl. 1: 35 (1891).Google Scholar
  181. 179.
    Koch, R., Uber die Aetiologie der Tuberculose, Verhandlungen des Kongresses fur Inner Medicin. Erst Kongress, Verlag von J. F. Bergmann, Weisbaden, 1882.Google Scholar
  182. 180.
    Komi, M. A., Farley, T. A., Ando, T., Curtis, M., Wilson, S. A., Jin, Q., Monroe, S. S., Baron, R. C., Mcfarland, L. M., and Glass, R. I., A large outbreak of Norwalk virus gastroenteritis associated with eating raw oysters: Implications for monitoring safe oyster beds, J.A.M.A. 273: 466–471 (1995).CrossRefGoogle Scholar
  183. 181.
    Konno, T., Suzuki, H., Imai, A., and Ihida, N., Reovirus-like agent in acute epidemic gastroenteritis in Japanese infants: Fecal shedding and serologic response, J. Infect. Dis. 135: 259–266 (1977).PubMedCrossRefGoogle Scholar
  184. 182.
    Koszinowski, U. H., Reddehase, M. J., and Jonac, S., The role of CD4 and CD8 T cells in viral infections, Curr. Opin. Immunol. 3: 471–475 (1991).PubMedCrossRefGoogle Scholar
  185. 183.
    Krugman, S., Viral hepatitis: A, B, C, D and E-infection, Pediatr. Rev. 13: 203–212 (1992).PubMedCrossRefGoogle Scholar
  186. 184.
    Lang, D. J., and Kummer, J. E, Demonstration of cytomegalovirus in semen, N. Engl. J. Med. 287: 756–758 (1972).PubMedCrossRefGoogle Scholar
  187. 185.
    Last, J. M., International Epidemiological Association, A Dictionary of Epidemiology, Oxford University Press, New York, 1988.Google Scholar
  188. 186.
    Last, J. M., and Wallace, R. B., Maxcy-Rosenau-Last Public Health and Preventive Medicine, 13th ed., Appleton and Lange, Norwalk, C. T., 1992.Google Scholar
  189. 187.
    Lennette, E. H., Magoffin, R. L., and Knauf, E. G., Viral central nervous system disease: An etiologic study conducted at the Los Angeles General Hospital, J.A.M.A. 179: 687–695 (1962).PubMedCrossRefGoogle Scholar
  190. 188.
    Leung, D. Y. M., Meissner, H. C., Fulton, D. R., Murray, D. L., Kotzin, B. L., and Schlievert, R. M., Toxic shock syndrome toxin-secreting Staphylococcus aureus in Kawasaki syndrome, Lancet 342: 1385–1388 (1983).CrossRefGoogle Scholar
  191. 189.
    Levy, R. M., and Berger, J. R., HIV and Htlv infections of the nervous system, in: Infectious Diseases of the Central Nervous System, Contemporary Neurology Series (L. Kern and J. B. Tyler, eds.), F A. Davis, Philadelphia, 1993.Google Scholar
  192. 190.
    Lewis, D. C., Lightfoot, N. F., Cubitt, D., and Wilson, S. A., Outbreaks of astrovirus type 1 and rotavirus gastroenteritis in a geriatric in-patient population, J. Hosp. Infect. 14: 9–14 (1989).PubMedCrossRefGoogle Scholar
  193. 191.
    Macasaet, F. F., Kidd, R A., Bolano, C. R., and Wenner, H. A., The etiology of acute respiratory infections. II. The role of viruses and bacteria, J. Pediatr. 72: 829–839 (1968).PubMedCrossRefGoogle Scholar
  194. 192.
    Mackewicz, C. E., Yang, L. C., Lifson, J. D., and Levy, J., Noncytolytic CD8T-cell and HIV responses in primary HIV infection, Lancet 344: 1671–1673 (1994).PubMedCrossRefGoogle Scholar
  195. 193.
    Mandell, G. L., Douglas, R. G., JR., and Bennett, J. E. (EDs.), Principles and Practices of Infectious Diseases, 4th ed., John Wiley & Sons, New York, 1994.Google Scholar
  196. 194.
    Marchette, N. J., Melish, M. E., Hicks, R., Kihara, S., Sam, E., and Ching, D., Epstein-Barr virus and other herpesvirus infections in Kawasaki syndrome, J. Infect. Dis. 161: 680–684 (1990).PubMedCrossRefGoogle Scholar
  197. 195.
    Marcus, R., and The CDC Cooperative Needlestick Surveillance Group, Surveillance of health care workers exposed to blood from patients infected with the human immunodeficiency virus, N. Engl. J. Med. 318: 1118–1123 (1988).CrossRefGoogle Scholar
  198. 196.
    Mason, J. O., and Mclean, W. R., Infectious hepatitis traced to consumption of raw oysters: An epidemiologic study, Am. J. Hyg. 75: 90–111 (1962).PubMedGoogle Scholar
  199. 197.
    May, R., and Anderson, R. M., Transmission dynamics of HIV infection, Nature 326: 137–142 (1987).PubMedCrossRefGoogle Scholar
  200. 198.
    Mcmichael, A. J., Ting, A., Zweerink, H. J., and Askonas, B. A., Hla restriction of cell-mediated lysis of influenza virusinfected cells, Nature 270: 524–526 (1977).PubMedCrossRefGoogle Scholar
  201. 199.
    Melnick, J. L., A water-borne urban epidemic of hepatitis, in: Hepatitis Frontiers (F. W. Hartman, ED.), pp. 211–225, Churchill, London, 1957.Google Scholar
  202. 200.
    Mermin, J. H., Holodniy, M., Katzenstein, D. A., and Merrigan, T. C., Detection of human immunodeficiency virus DNA and Rna in semen by the polymerase chain reaction, J. Infect. Dis. 164: 769–772 (1991).PubMedCrossRefGoogle Scholar
  203. 201.
    Mims, C. A., The Pathogenesis of Infectious Diseases, 3rd ed., Academic Press, London, 1987.Google Scholar
  204. 202.
    Mims, C. A., Curner, M. L., and Kelly, R. E. (eds.), Viruses and Demyelinating Diseases, Academic Press, New York, 1983.Google Scholar
  205. 203.
    Morrro, A. S., and Johnson, K. M., A community study of respiratory infections in the tropics. I. Description of the community and observation on the activity of certain respiratory agents, Am. J. Epidemiol. 86: 78–92 (1967).Google Scholar
  206. 204.
    Morens, D. M., Boston exanthem agent: Echovirus 16, Am. J. Dis. Child. 131: 1306 (1977).PubMedGoogle Scholar
  207. 205.
    Morens, D. M., Antibody-dependent enhancement of infection and the pathogenesis of viral disease, Clin. Infect. Dis. 19: 500–512 (1994).PubMedCrossRefGoogle Scholar
  208. 206.
    Morgan, A. J., Recent progress in EBV vaccine development, in: Epstein-Barr Virus and Associated Diseases (T. Tursz, J. S. Pagano, D. V. Ablashiet, G. DE The, G. Lenoir, and G. Pearson, eds.), pp. 593–598, Collogue/Inserm, John Libbey, Eurotext, London, 1993.Google Scholar
  209. 207.
    Mueller, N., Epidemiologic studies assessing the role of the Epstein-Barr virus in Hodgkin’s disease, Yale J. Biol. Med. 60: 321–327 (1987).PubMedGoogle Scholar
  210. 208.
    Mueller, N., Evans, A. S., and London, W. T., Viruses, in: Cancer Epidemiology and Prevention, 2nd ed. (D. Schottenfeld and J. F. Fraumeni, eds.), Oxford University Press, New York, 1996.Google Scholar
  211. 209.
    Mueller, N., Mohar, A., Evans, A., Harris, N. L., and The Members of the EBV-NHL Collaboration, Epstein-Barr virus antibody patterns preceding the diagnosis of non-Hodgkin’s lymphoma, Int. J. Cancer 49: 387–393 (1991).Google Scholar
  212. 210.
    Mufson, M. A., Chang, V., Gill, V., Wood, S. C., Romansky, M. J., and Chanock, R. M., The role of viruses, mycoplasmas and bacteria in acute pneumonia in civilian adults, Am. J. Epidemiol. 86: 526–544 (1967).PubMedGoogle Scholar
  213. 211.
    Mullis, K. B., Johnson, P. E., and Thomas, C. A., Dissenting on AIDS, San Diego Union-Tribune, Section G, May 15, 1994.Google Scholar
  214. 212.
    Munoz, A., Kirby, A. J., HE, Y. D., Margolick, J. B., Visscher, B. R., Rinaldo, C. R., Kaslow, R. A., and Phair, J. P., Long-term survivors with HIV-1 infection: Incubation period and longitudinal patterns of CD4+ lymphocytes, J. Acquir. Immune Dis. Syndr. 8: 496–505 (1995).CrossRefGoogle Scholar
  215. 213.
    Nathanson, N., Epidemiology in: Virology (B. Fields, D. M. Knipe, R. M. Chanock, M. S. Hirsch, J. L. Melnick, T. P. Monath, and B. Roizman, eds.), pp. 267–291, Raven Press, New York, 1990.Google Scholar
  216. 214.
    National Institute of Allergy and Infectious Diseases, Program for accelerated development of new vaccines, 1985 Progress Report, Nih, Bethesda, 1985.Google Scholar
  217. 215.
    National Institute of Allergy and Infectious Diseases, The Jordan Report, 1994.Google Scholar
  218. 216.
    Nicholson, K. G., Antiviral therapy. Respiratory infections, genital herpes, and hepatitis keratitis, Lancet 2: 617–621 (1984).PubMedCrossRefGoogle Scholar
  219. 217.
    Nicolosi, A., HIV Epidemiology: Models and Methods, Raven Press, New York, 1994.Google Scholar
  220. 218.
    Nicolosi, A., Leite, M. L. C., Musicco, M., Molinari, S., and Lazzarin, A., Parenteral and sexual transmission of human immunodeficiency virus in intravenous drug users: A study of seroconversion, Am. J. Epidemiol. 135: 225–233 (1992).PubMedGoogle Scholar
  221. 219.
    Niederman, J. C., Mccollum, R. W., Henle, G., and Henle, W., Infectious mononucleosis: Clinical manifestations in relation to EB virus antibodies, J.A.M.A. 203: 205–209 (1968).PubMedCrossRefGoogle Scholar
  222. 220.
    Offit, P. A., and Dudzik, K. I., Rotavirus-specific cytotoxic T lymphocytes passively protect against gastroenteritis in suckling mice, J. Virol. 64: 6325–6328 (1990).PubMedGoogle Scholar
  223. 221.
    Olson, L. C., Lexomboon, U., Sithisarn, P., and Noyes, H. E., The etiology of respiratory tract infections in a tropical country, Am. J. Epidemiol. 97: 34–43 (1973).PubMedGoogle Scholar
  224. 222.
    Oseasohn, R., Adelson, L., and Kati, M., Clinical pathological study of 33 fatal cases of Asian influenza, N. Engl. J. Med. 260: 509–518 (1959).PubMedCrossRefGoogle Scholar
  225. 223.
    OU, C.-Y., Cibsielski, C. A., Myers, G., Bandea, C. I., Luo, C.-C., Korber, B. T. M., Mullins, J. I., Schochetman, G., Berkelman, R. L., Economou, A. N., Wite, J. J., Furman, L. J., Satten, G. A., Macinnes, K. A., Curran, J. W., and Jaffe, H. W., Molecular epidemiology of HIV transmission in a dental practice, Science 256: 1165–1170 (1992).PubMedCrossRefGoogle Scholar
  226. 224.
    Pagano, J. S., Huang, C. H., and Levine, P., Absence of Epstein-Barr viral DNA in American Burkitt’s lymphoma, N. Engl. J. Med. 389: 1195–1199 (1973).Google Scholar
  227. 225.
    Pan American Health Organization, The certification of wild poliovirus eradication from the Western hemisphere, Epidemiol. Bull. 15: 1–3 (1994).Google Scholar
  228. 226.
    Paul, J. R., Clinical Epidemiology, 2nd ed., University of Chicago Press, Chicago, 1966.Google Scholar
  229. 227.
    Pearce, E. J., Caspar, P., Grzych, J.-M., Lewis, E A., and Sher, A., Downregulation of Thl cytokine production accompanies induction of Th2 responses by a parasitic helminth, Schistosoma mansoni, J. Exp. Med. 173: 159–166 (1991).CrossRefGoogle Scholar
  230. 228.
    Peters, C. J., and Anderson, G. W., Pathogenesis of Rift Valley fever, Contrib. Epidemiol. Biostat. 3: 21–41 (1981).Google Scholar
  231. 229.
    Philips, P. E., and Christian, C. L., Myxovirus antibody increases in human connective tissue disease, Science 168: 982–984 (1970).CrossRefGoogle Scholar
  232. 230.
    Plummer, E A., Simonsen, J. N., Cameron, D. W., Ndinyaachola, J. O., Kreiss, J. K., Gakinya, M. N., Waiyaki, P., Cheang, M., Plot, P., Ronald, A. R., and Ngugi, E. N., Cofactors in male-female transmission of human immunodeficiency virus type 1, J. Infect. Dis. 163: 233–239 (1991).PubMedCrossRefGoogle Scholar
  233. 231.
    Prusinger, S. B., Molecular biology of prion diseases, Science 252: 1515–1522 (1991).CrossRefGoogle Scholar
  234. 232.
    Public Health Laboratory Service Working Party on Fifth Disease, Prospective study of human parvovirus (B19) infection in pregnancy, Br. Med. J. 300: 1166–1170 (1990).Google Scholar
  235. 233.
    Purtilo, D. T., Hurr, L., Bhawan, J. P. S., Allegro, S., and Rosen, E S., Immunodeficiency to the Epstein-Barr virus in the X-linked recessive lymphoproliferative syndrome, Clin. Immunol. Monogr. 9: 147–156 (1978).Google Scholar
  236. 234.
    Purtilo, D. T., and Lai, P. K., Clinical and immunopathological manifestations and detection of Epstein-Barr virus infection in immune deficient patients, in: Medical Virology VI (L. M. de la Maza and E. M. Peterson, Eds.), pp. 121–167, Elsevier Publications, Amsterdam, 1987.Google Scholar
  237. 235.
    Purtilo, D. T., Strobach, R. S., Okano, M., and Davis, J. R., Epstein-Barr virus-associated lymphoproliferative disorders, Lab. Invest. 67: 5–23 (1992).PubMedGoogle Scholar
  238. 236.
    Remington, J. S., and Klein, J. O. (eds.), Infectious Diseases of the Fetus and Newborn Infant, 3rd ed., W. B. Saunders, Philadelphia, 1990.Google Scholar
  239. 237.
    Rivers, T., Viruses and Koch’s postulates, J. Bacteriol. 33: 1–12 (1937).PubMedGoogle Scholar
  240. 238.
    Rosenberg, P. S., Goedert, J. J., and Biggar, R. J., Effect of age at seroconversion on the natural AIDS incubation distribution, AIDS 8: 803–810 (1994).PubMedCrossRefGoogle Scholar
  241. 239.
    Rothfield, N. E, Evans, A. S., and Niederman, J. C., Clinical and laboratory aspects of raised virus antibody titers in systemic lupus erythematosus, Ann. Rheum. Dis. 32: 238–246 (1973).PubMedCrossRefGoogle Scholar
  242. 240.
    Sabin, A. B., and Silva, E., Residual paralytic poliomyelitis in a tropical region of Brazil, 1969–1977: Prevalent surveys in different age groups as indicators of changing incidence, Am. J. Epidemiol. 117: 193–200 (1983).PubMedGoogle Scholar
  243. 241.
    Sawyer, R. N., Evans, A. S., Niederman, J. C., and Mccoumm, R. W., Prospective studies of a group of Yale University freshmen. I. Occurrence of infectious mononucleosis, J. Infect. Dis. 123: 263–270 (1971).Google Scholar
  244. 242.
    Schmid, D. S., and Rouse, B. T., The role of T cell immunity in control of herpes simplex virus, Curr. Top. Microbiol. Immunol. 179: 57–74 (1992).PubMedCrossRefGoogle Scholar
  245. 243.
    Schulman, J., Transmissibility as a separate genetic attribute of influenza viruses, in: Aerobiology (I. H. Silver, ED.), pp. 248–259, Academic Press, New York, 1970.CrossRefGoogle Scholar
  246. 244.
    Sharpe, A. H., and Fields, B. N., Pathogenesis of viral infections; basic concepts derived from a reovirus model, N. Engl. J. Med. 312: 486–496 (1985).PubMedCrossRefGoogle Scholar
  247. 245.
    Shah, K. V., Daniel, R. W., and Warzawski, R. M., High prevalence of antibodies to BK virus, and SV40-related papova virus, in residents of Maryland, J. Infect. Dis. 128: 784–787 (1973).PubMedCrossRefGoogle Scholar
  248. 246.
    Shope, R. E., Swine influenza. I. Experimental transmission and pathology, J. Exp. Med. 54: 349–359 (1931).PubMedCrossRefGoogle Scholar
  249. 247.
    Singer, B., Mathematic models of infectious diseases: Seeking new tools for planning and evaluating child survival control programs, Popul. Dev. Rev. 10 (Suppl.): 347–365 (1984).CrossRefGoogle Scholar
  250. 248.
    Smith, D. K., Neal, J. J., Holmberg, S. D., and The Centers for Disease Control Idiopathic CD4+ T-Lymphocytopenia Task Force, Unexplained opportunistic infections and CD4+ T-lymphocytopenia without HIV infection, N. Engl. J. Med. 328: 373–379 (1983).Google Scholar
  251. 248a.
    Spooner, K. M., Lane, H. C., and Masur, H., Guide to major clinical trials of antiretroviral therapy administered to patients infected with human immunodeficiency virus, Clin. Infect. Dis. 23: 15–27 (1996).PubMedCrossRefGoogle Scholar
  252. 249.
    Stagno, S., Cloud, G., Pass, R. F., Britr, W. J., and Alford, C. A., Factors associated with primary cytomegalovirus infection during pregnancy, J. Med. Virol. 13: 347–353 (1984).PubMedCrossRefGoogle Scholar
  253. 250.
    Stagno, S., Pass, R. F., Dworsky, M. E., and Alford, C. A., Maternal cytomegalovirus infection and perinatal transmission, Clin. Obstet. Gynecol. 25: 563–576 (1982).PubMedCrossRefGoogle Scholar
  254. 251.
    Stoeckel, P., Schlumberger, M., Parent, G., Maire, B., Vanwenzel, A., Van Steenis, G., Evans, A., and Salk, D., Use of killed poliovirus vaccine in a routine immunization program in West Africa, Rev. Infect. Dis. 6 (Suppl. 2): S463–466 (1984).PubMedCrossRefGoogle Scholar
  255. 252.
    Strebel, P. M., Sutter, R. W., Cociu, S. L., Biellik, R. J., Kew, O. M., Pallansch, M. A., Orenstein, W. A., and Hinman, A. R., Epidemiology of poliomyelitis in the United States: One decade after the last reported case of indigenous wild virus-associated disease, Clin. Infect. Dis. 14: 568–579 (1992).PubMedCrossRefGoogle Scholar
  256. 253.
    Stuart-Harris, C., Can infectious disease be eliminated? A report on the international conference on the eradication of infectious disease, Foreword, Rev. Infect. Dis. 4: 913–914 (1982).CrossRefGoogle Scholar
  257. 254.
    Sullivan, J. L., and Woda, B. A., X-linked lymphoproliferative syndrome, Immunodeflc. Rev. 1: 325–347 (1989).Google Scholar
  258. 255.
    Sullivan-Bolyai, J., Hull, H. F., Wilson, C., and Corey, L., Neonatal herpes simplex virus infection in King County, Washington: Increasing incidence and epidemiologic correlates, J.A.M.A. 250: 3059–3062 (1983).Google Scholar
  259. 256.
    Takimoto, C. H., Cram, D. L., and Root, R. K., Respiratory syncytial virus infections on an adult medical ward, Arch. Intern. Med. 151: 706–708 (1991).PubMedCrossRefGoogle Scholar
  260. 257.
    Thompson, W. H., and Evans, A. S., California virus studies in Wisconsin, Am. J. Epidemiol. 81: 230–234 (1965).PubMedGoogle Scholar
  261. 258.
    Tindall, B., and Cooper, D. A., Primary HIV infection: Host responses and intervention strategies, AIDS 5: 1–14 (1991).PubMedCrossRefGoogle Scholar
  262. 259.
    Tindall, B., Evans, L., Cunningham, R, Mcqueen, R, Hurren, L., Vasak, E., Mooney, J., and Cooper, D. A., Identification of HIV-1 in semen following primary HIV-1 infection, AIDS 6: 949–952 (1992).PubMedCrossRefGoogle Scholar
  263. 260.
    Tokars, J. I., Marcus, R., Culver, D. H., Schable, C. A., Mckibben, R S., Bandea, C. I., and Bell, D. M., Surveillance of HIV infection and zidovudine use among health care workers after occupational exposure to HIV-infected blood, Ann. Intern. Med. 118: 913–919 (1993).PubMedCrossRefGoogle Scholar
  264. 261.
    Tompkins, L. S., The use of molecular methods in infectious diseases, N. Engl. J. Med. 327: 1290–1297 (1992).PubMedCrossRefGoogle Scholar
  265. 262.
    Torres, B. V., Ilia, R. M., and Esparza, J., Epidemiological aspects of rotavirus infection in hospitalized Venezuelan children with gastroenteritis, Am. J. Trop. Med. Hyg. 27: 567–572 (1978).PubMedGoogle Scholar
  266. 263.
    Two, S. J., Detels, R., Nelson, K., Visscher, B. R., Kaslow, R., Palenicek, J., and Phair, J., Relationship of hepatitis B virus infection to human immunodeficiency virus type 1 infection, J. Infect. Dis. 167: 299–304 (1993).CrossRefGoogle Scholar
  267. 264.
    University Health Physicians and PHLS Laboratories, A joint investigation: Infectious mononucleosis and its relationship to EB virus antibody, Br. Med. J. 4: 643–646 (1971).Google Scholar
  268. 265.
    Untermohlen, V., and Zabriskie, J. E, Suppressed cellular immunity to measles antigen in multiple-sclerosis patients, Lancet 2: 1147–1148 (1973).Google Scholar
  269. 266.
    Urquhardt, G. E. D., and Stoti, E. J., Rhinoviraemia, Br. Med. J. 4: 28–30 (1970).CrossRefGoogle Scholar
  270. 267.
    Utagawa, E. T., Nishizawa, S., Sekine, S., Hayashi, Y., Ishihara, Y., Oishi, I., Iwasaki, A., Yamashita, I., Miyamura, K., Yamazaki, S., Inouye, S., and Glass, R. I., Astrovirus as a cause of gastroenteritis in Japan, J. Clin. Microbiol. 32: 1841–1845 (1994).PubMedGoogle Scholar
  271. 268.
    Valenti, W. M., Selected viruses of nosocomial importance, in: Hospital Infections, 3rd ed. (J. V. Benneti, S. P. Sanford, and R. S. Brachman, eds.), pp. 789–821, Little, Brown, Boston, 1992.Google Scholar
  272. 269.
    Van Dersus, I. H., and Wiltink, E. H., Antiviral drugs: Present status and future prospects, Int. J. Biochem. 26: 621–630 (1994).CrossRefGoogle Scholar
  273. 270.
    Vlahov, D., Anthony, J. D., Munoz, A., Margolick, J., Nelson, K. E., Celentano, D. D., Solomon, L., and Polk, B. F., The Alive study, a longitudinal study of HIV-1 infection in intravenous drug users, NIDA Res. Monogr. 109: 75–100 (1991).PubMedGoogle Scholar
  274. 271.
    Vonka, V., Kanka, J., Jelinek, J., Subrt, I., Suchanek, A., Havrankova, A., Vachal, M., Hirsch, I., Domorazkova, E., Zavadova, H., Richterova, V., Naprstkova, J., Dvorakova, V., and Svoboda, B., Prospective study on the relationship between cervical neoplasia and herpes simplex, type-2 virus. I. Epidemiological characteristics, Int. J. Cancer 33: 49–60 (1984).PubMedCrossRefGoogle Scholar
  275. 272.
    Walker, C. M., Moody, D. J., Stites, D. R, and Levy, J. A., CD8+ lymphocytes can control HIV infection in vitro by suppressing virus replication, Science 234: 1563–1566 (1986).PubMedCrossRefGoogle Scholar
  276. 273.
    Whitley, R. J., and Gnann, J. W., Acyclovir: A decade later, N. Engl. J. Med. 327: 782–789 (1992).PubMedCrossRefGoogle Scholar
  277. 274.
    Wilson, C. B., Dixon, F. J., Evans, A. S., and Glasock, R. J., Anti-viral antibody responses in patients with renal disease, Clin. Immunol. Immunopathol. 2: 121–132 (1973).PubMedCrossRefGoogle Scholar
  278. 275.
    Wilson, C. W., Stevenson, D. K., and Arvin, A. M., A concurrent epidemic of respiratory syncytial virus and echovirus 7 infections in an intensive care nursery, Pediatr. Infect. Dis. J. 8: 24–29 (1989).PubMedCrossRefGoogle Scholar
  279. 276.
    Winkelstein, W., Wiley, J. A., Padian, N. S., Samuel, M., Shmoslu, S., Ascher, M., and Levy, J. A., The San Francisco Men’s Health Study: Continued decline in HIV seroconversion rates among homosexual/bisexual men, Am. J. Public Health 78: 1472–1474 (1988).PubMedCrossRefGoogle Scholar
  280. 277.
    Wofsy, C., Cohen, J., Haner, L. B., Padra, N., Michaels, B., Evans, L., and Levy, J. A., Isolation of AIDS-associated retro-virus from genital secretions of women and antibodies to the virus, Lancet 1: 527–528 (1986).PubMedCrossRefGoogle Scholar
  281. 278.
    World Health Organization, Smallpox surveillance, Week. Epidemiol. Rec. 54: 1–6 (1979).Google Scholar
  282. 279.
    World Health Organization, Expanded Programme on Immunization, Document EB 69/25, March 25, 1982.Google Scholar
  283. 280.
    World Health Organization, Expanded programme on immunization, global advisory group-Part I, Week. Epidemiol. Rec. 68: 1–6 (1993).Google Scholar
  284. 281.
    World Health Organization, Expanded programme on immunization, global advisory group-Part II, Week. Epidemiol. Rec. 68: 11–15 (1993).Google Scholar
  285. 282.
    World Health Organization, The current global situation of the HIV/AIDS pandemic, Week. Epidemiol. Rec. 70: 7–8 (1995).Google Scholar
  286. 283.
    Yamanishi, K., Okuno, T., Shiraki, K., Takahashi, M., Kondo, T., Asano, Y., and Kurata, T., Identification of a human herpesvirus-6 as causal agent for exanthem subitum, Lancet 1: 1065–1067 (1988).PubMedCrossRefGoogle Scholar
  287. 284.
    Yolken, R. H., Bishop, C. A., Townsend, T. R., Bolyard, E. A., Bartlett, J., Santos, G. W., and Saral, R., Infectious gastroenteritis in bone marrow-transplant recipients, N. Engl. J. Med. 306: 1009–1012 (1982).CrossRefGoogle Scholar
  288. 285.
    Yolken, R. H., Wyatt, R. G., Zisais, G., Brandt, C. D., Rodriguez, W. J., Kim, H. W., Parrott, R. H., Urria, J. J., Mata, L., Greenberg, H. B., Kapikian, A. Z., and Chanock, R. M., Epidemiology of human rotavirus types 1 and 2 as studied by enzyme-linked immunosorbent assay, N. Engl. J. Med. 299: 1156–1161 (1978).PubMedCrossRefGoogle Scholar
  289. 286.
    Yoto, Y., Kudoh, T., Haseyama, K., Suzuki, N., Chiba, S., and Matsunaga, Y., Human parvovirus B19 infection in Kawasaki disease, Lancet 344: 58–59 (1994).PubMedCrossRefGoogle Scholar
  290. 287.
    Zeldis J. B. and Crumpacker, C. S., Hepatitis, in: Infectious Diseases of the Fetus and Newborn Infant, 3rd ed. (J. S. Remington and J. O. Klein, eds.), pp. 574–600, W. B. Saunders, Philadelphia, 1990.Google Scholar
  291. 288.
    Zinkernagel, R. M., Immunity to viruses, in: Fundamental Immunology, 3rd ed., (W. Paul, ED.), pp. 1211–1250, Raven Press, New York, 1993.Google Scholar
  292. 289.
    Zur Hausen, H., Papilloma virus/host cell interaction in the pathogenesis of anorectal cancer, in: Origins of Human Cancer: A Comprehensive Review (J. Brugge, T. Curran, E. Hadlow, and E. Mccormick, eds.), pp. 685–705, Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY, 1991.Google Scholar
  293. 290.
    Zweerink, H. J., and Stanton, L. W., Immune response to Hsv infections: Virus specific antibodies in sera from patients with recurrent facial infections, Infect. Immun. 31: 624–630 (1981).PubMedGoogle Scholar

Suggested Reading

  1. Belshe, R. B. (ED.), Textbook of Human Virology, 2nd ed., Mosby Year Book Medical, St. Louis, 1991.Google Scholar
  2. Benenson, A. S. (ED.), Control of Communicable Diseases in Man, 15th ed., American Public Health Association, Washington, DC, 1990.Google Scholar
  3. Christie, A. B., Infectious Diseases: Epidemiology and Clinical Practice, 3rd ed., E. & S. Livingston, Edinburgh, 1987.Google Scholar
  4. Davis, B. D., Dulbecco, R., Eisen, H. N., and Ginsberg, H. S. (eds.), Microbiology, 4th ed., Lippincott, Philadelphia, 1990.Google Scholar
  5. Evans, A. S., and Brachman, P. S. (EDs.), Bacterial Infections of Humans. Epidemiology and Control, Plenum Press, New York, 1991.CrossRefGoogle Scholar
  6. Fenner, E J., and White, D. O., Medical Virology, 3rd ed., Academic Press, Orlando, FL, 1990.Google Scholar
  7. Fields, B. N., Knipe, D. M., Chanock, R. M., Melnick, J. L., Roizman, B., and Shope, R. E. (Ens.), Field’s Virology, 2nd ed., Raven Press, New York, 1990.Google Scholar
  8. Fraenkel-Conrat, H., and Kimball, P. C., Virology, 2nd ed., Prentice-Hall, Englewood Cliffs, NJ, 1988.Google Scholar
  9. Friedman, G. D., Primer of Epidemiology, 3rd ed., McGraw-Hill, New York, 1988.Google Scholar
  10. Golub, E. S., Immunology, a Synthesis, 2nd ed., Sinauer Associates, Sunderland, MA, 1991.Google Scholar
  11. Hennekens, C. H., Buring, J. E., and Mayrent, S. L., Epidemiology in Medicine, Little, Brown, Boston, 1987.Google Scholar
  12. Holland, W. W., Detels, R., and Knox, G. E. (eds.), Oxford Textbook of Public Health, 2nd ed., Oxford University Press, Oxford, 1991.Google Scholar
  13. Kelsey, J. L., Thompson, W. D., and Evans, A. S., Methods in Observational Epidemiology, Oxford University Press, New York, 1986.Google Scholar
  14. Last, J. M., International Epidemiological Association, A Dictionary of Epidemiology, Oxford University Press, New York, 1988.Google Scholar
  15. Last, J. M., and Wallace, R. B., Maxcy-Rosenau-Last Public Health and Prevention Medicine, 13th ed., Appleton and Lange, Norwalk, CT, 1992.Google Scholar
  16. Lilienfeld, A. M., and Lilienfeld, D. E., Foundations of Epidemiology, 2nd ed., Oxford University Press, New York, 1982.Google Scholar
  17. Mandell, G. L., Douglas, R. G., and Bennett, J. E. (eds.), Principles and Practice of Infectious Diseases, 4th ed., John Wiley & Sons, New York, 1994.Google Scholar
  18. Mims, C. A., The Pathogenesis of Infectious Diseases, 3rd ed., Academic Press, London, 1987.Google Scholar
  19. Notkins, A., Concepts in Viral Pathogenesis III, Springer-Verlag, New York, 1989.CrossRefGoogle Scholar
  20. Notkins, A. L., and Oldstone, B. A. (eds.), Concepts in Viral Pathogenesis, Springer-Verlag, New York, 1984.CrossRefGoogle Scholar
  21. Paul, W. (ED.), Fundamental Immunology, 3rd ed., Raven Press, New York, 1993.Google Scholar
  22. Remington, J. S., and Klein, J. O. (eds.), Infectious Diseases of the Fetus and Newborn Infant, 3rd ed., W. B. Saunders, Philadelphia, 1990.Google Scholar
  23. Rorri, I., Essential Immunology, 8th ed., Blackwell Scientific Publications, Oxford, 1994.Google Scholar
  24. Rothman, K., Modern Epidemiology, Little, Brown, Boston, 1986.Google Scholar
  25. Thomas, D. B., Viruses and the Cellular Immune Response, Marcel Dekker, London, 1993.Google Scholar
  26. Volk, W. A., Essentials of Medical Microbiology, 4th ed., Lippincott, Philadelphia, 1991.Google Scholar
  27. Webster, R. G., and Granoff, A., Encyclopedia of Virology, Academic Press, London, 1994.Google Scholar
  28. Zuckerman, A. J., Banatvala, J. E., and Pattison, J. R. (eds.), Principles and Practices of Clinical Virology, 3rd ed., John Wiley, Chichester, England, 1994.Google Scholar

Copyright information

© Springer Science+Business Media New York 1997

Authors and Affiliations

  • Richard A. Kaslow
    • 1
  • Alfred S. Evans
    • 2
  1. 1.Department of Epidemiology, School of Public HealthUniversity of Alabama at BirminghamBirminghamUSA
  2. 2.Department of Epidemiology and Public HealthYale University School of MedicineNew HavenUSA

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