p53 Protein Expression in Thymic Epithelial Tumors
We investigated the expression of p53 protein by immunohistochemical analysis using the anti-p53 polyclonal antibody (CM-1) in 12 thymomas and 13 thymic carcinomas.
All 6 noninvasive thymomas showed an absence of nuclear staining, and one of the 7 invasive thymomas (14%) showed nuclear staining focally. Eight of the 12 thymic carcinomas (67%) showed nuclear staining. Three of 8 cases showed nuclear staining in more than 50% of the tumor cells.
p53 protein accumulation is highly frequent in thymic carcinomas, but not in thymomas. The accumulation of p53 protein seems to play an important role in the carcinogenesis of thymic carcinomas.
KeywordsNuclear Staining Thymic Carcinoma Spindle Cell Carcinoma Thymic Epithelial Tumor Invasive Thymoma
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