The classification of thymomas has often represented a troublesome topic for the pathologist. In the attempt to correlate the various histologic subtypes with the clinical behaviour and the prognosis of the tumors, Marino and Müller-Hermelink5 and Kirchner et al.2 proposed a new histogenetic classification of thymomas based on the similarities between neoplastic epithelial cells and normal thymic components. In the present study, 60 thymomas were reclassified according to the histogenetic classification and their clinicopathological data were evaluated in order to assess if any histological features could correlate with the stage of the tumor, therefore being worth reporting in the histopathologic diagnosis. Besides, we performed an immunocytochemical study, to assess whether the positivity to the Ki-67 antigen, as evaluated by the monoclonal antibody MIB-1, could add any remarkable data about the proliferation rate of the neoplastic cells.
KeywordsThymic Carcinoma Thymic Epithelial Tumor Neoplastic Epithelial Cell Invasive Thymoma Histological Progression
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