Thymoma—Prognostic Factors and Outcome

  • Kristina Friström
  • A. Cervin
  • J. P. Enoksson
  • M. Albertsson
  • L. Johansson


Thymomas are common mediastinal lesions, especially in association with myasthenia gravis. Here we report a material of 67 patients treated for thymoma. The incidence of myasthenia gravis was 43%. There was no difference in relapse-free survival for patients with or without myasthenia gravis, nor taken into concideration autoimmune diseases in general. Twenty-seven per cent had no symptoms of their tumor and this group fared better regarding relapse-free survival during a follow-up of nine years. There was no significant difference regarding survival neither for age, nor sex, however a significant difference was noted in relation to stage I–IV. Eighty-two per cent were macroscopically radically resected and 28% had some kind of further treatment, and in the latter group survival was significantly lower.

The patients are followed up to ten years. Twenty-one patients have passed away. Forty-five patients are alive with no evidence of disease. One patient is alive with disease.

Thymomas are often malignant (about 25%), but they rarely metastasize. Their malignant potential is demonstrated by a direct invasion of the lung, pericardium, blood vessels, and lymphatics.


Merkel Cell Carcinoma Thymic Carcinoma Mediastinal Tumor Polymyalgia Rheumatica Invasive Thymoma 
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  1. 1.
    Lattes R.; Thymoma and other types of tumor of the thymus, an analysis of 107 cases.; Cancer 15:1224–1260,1962.CrossRefGoogle Scholar
  2. 2.
    Marino M, Müller-Hermelink HK; Thymoma and thymic carcinoma. Relation of thymoma epithelial cells to the cortical and medullary differentiation of the thymus.; Virchows Arch A Pathol Anat Histopathol. 407:119–49,1985.PubMedCrossRefGoogle Scholar
  3. 3.
    Masaoka et al.; Follow-up study of thymomas with specal reference to their clinical stages.; Cancer 48: 2485–2492, 1981.PubMedCrossRefGoogle Scholar
  4. 4.
    Kirchner T, Müller-Hermelink HK; New approaches to the diagnosis of thymic epithelial tumors.; Prog Surg Pathol 10:167–189, 1989.Google Scholar
  5. 5.
    Kirchner T et al.; Well differentiated thymic carcinoma: an organotypical low-grade carcinoma with relationship to cortical thymoma. Am J Surg Pathol. 16: 1153–1169, 1992PubMedCrossRefGoogle Scholar
  6. 6.
    Ryback LP.; Metastatic thymoma to the head and neck.; Laryngoscope 98:418–421, 1988.Google Scholar
  7. 7.
    Batata M.A. et al.; Thymomas: Clinicopathological Features, Therapy and prognosis.; Cancer, 34:389–396, 1974.PubMedCrossRefGoogle Scholar
  8. 8.
    Wick M R et al.; Primary Thymic Carcinomas.; Am J. Surg. Pathol, &:229-242,1982.Google Scholar
  9. 9.
    Monden Y et al.; Recurrence of thymoma: Clinicopathological features, Therapy and Prognosis.; The Annals of Thoracic Surgery, 39, 2, 165–169, 1985.PubMedCrossRefGoogle Scholar
  10. 10.
    Arrigada R et al.; Invasive carcinoma of thymus. A multicenter retrospective review of 56 cases.; Eur, J Cancer 20:69–74, 1984.CrossRefGoogle Scholar
  11. 11.
    Uematsu M et al.; A proposal of treatment of invasive thymoma.; Cancer 58:1979–1984, 1986.PubMedCrossRefGoogle Scholar
  12. 12.
    Arakawa A et al.; Radiation therapy of invasive thymoma.; Int. J. Radiat. Oncol, Biol. Phys. 18:529–534, 1990.CrossRefGoogle Scholar
  13. 13.
    Daugaard G et al.; Combination therapy for malignant thymoma.; Ann Intern. Med. 998:189–190, 1983.CrossRefGoogle Scholar
  14. 14.
    Daugaard G.; the effect of chemotherapy in the treatment of malignant thymoma.; In Sarrzin, Vrousos, Vincent (eds.): Thymic Tumors, Karger Basel 1989, pp 112-119.Google Scholar
  15. 15.
    Loehrer Pj et al.; Chemotherapy for advanced thymoma. Preliminary results of an intergroup study.; Ann, Intern. Med. 113:520–524, 1990.CrossRefGoogle Scholar
  16. 16.
    Fornasiero A et al.; Chemotherapy of invasive thymoma.; J. Clin. Oncol. 8:1419–1423, 1990.PubMedGoogle Scholar
  17. 17.
    Ewans W.K, etal.; Combination chemotherapy in invasive thymoma. Role of COPP.; Cancer 46:1523–1527, 1980.CrossRefGoogle Scholar
  18. 18.
    Tseng-Tong Kuo et al.; Thymoma: a study of the pathology classification of 71 cases with evaluation of the Müller-Hermelink system; Human Pathology vol. 247:766–778, 1993.Google Scholar
  19. 19.
    Quintanilla-Martinez L, etal.; Thymoma — morphologic sub classification correlates with invasiveness and immunohistologic features: a study of 122 cases; Human Pathology vol. 249:958–969, 1993.CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1997

Authors and Affiliations

  • Kristina Friström
    • 1
  • A. Cervin
    • 1
  • J. P. Enoksson
    • 1
  • M. Albertsson
    • 1
  • L. Johansson
    • 1
  1. 1.Departments of Oncology and PathologyUniversity HospitalLundSweden

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