Thymoma and Myasthenia Gravis

Incidence of Tumor Recurrences in 126 Patients
  • A. Evoli
  • A. P. Batocchi
  • M. T. Palmisani
  • L. Lauriola
  • G. B. Doglietto
  • P. Tonali


The prognosis of thymoma appears to be correlated mainly with the extent of the tumor, the radically of surgical exeresis1,2 and, as it has recently been reported, with the histological type.3 Association with myasthenia gravis (MG) does not adversely affect patients’ survival.4


Thymic Carcinoma Masaoka8 Stag Invasive Thymoma Thymoma Recurrence Noninvasive Thymoma 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Urgesi A, Monetti U, Rossi G, Ricardi U, Maggi G, Sannazzari GL: Aggressive treatment of intrathoracic recurrences of thymoma. Radiother Oncol 1992, 24:221–225.PubMedCrossRefGoogle Scholar
  2. 2.
    Wilkins EW Jr, Grillo HC, Scannel JG, Moncure AC, Mathisen DJ: Role of staging in prognosis and management of thymoma. Ann Thorac Surg 1991, 51:888–892.PubMedCrossRefGoogle Scholar
  3. 3.
    Quintanilla-Martinez L, Wilkins EW Jr, Ferry JA, Harris NL: Thymoma. Morphologic subclassification correlates with invasiveness and immunohistologic features: a study of 122 cases. Hum Pathol 1993, 24:958–969.PubMedCrossRefGoogle Scholar
  4. 4.
    Cooper JD: Current therapy for thymoma. Chest 1993, 103 (Suppl): 334S-336SGoogle Scholar
  5. 5.
    Ohmi M, Ohuchi M: Recurrent thymoma in patients with myasthenia gravis. Ann Thorac Surg 1990, 50:243–247.PubMedCrossRefGoogle Scholar
  6. 6.
    Kirschner PA: Reoperation for thymoma; report of 23 cases. Ann Thorac Surg 1990, 49:550–555.PubMedCrossRefGoogle Scholar
  7. 7.
    Maggi G, Casadio C, Cavallo A, Cianci R, Molinatti M, Ruffini: Thymoma: results of 241 operated cases. Ann Thorac Surg 1 991, 51: 152-156Google Scholar
  8. 8.
    Masaoka A, Monden Y, Nakahara K, Tanioka T: Follow-up study of thymomas with special reference to their clinical stages. Cancer 1981, 48:2485–2492.PubMedCrossRefGoogle Scholar
  9. 9.
    Marino M, Muller-Hermelink HK: Thymoma and thymic carcinoma. Relation of thymoma epithelial cells to the cortical and medullary differentiation of the thymus. Virchows Arch Pathol Anat 1985, 407:119–149.CrossRefGoogle Scholar
  10. 10.
    Kirchner T, Schalke B, Buchwald J, Ritter M, Marx A, Muller-Hermelink HK: Well-differentiated thymic carcinoma. An organotypical low-grade carcinoma with relationship to cortical thymoma. Am J surg Pathol 1992, 16:1153–1169.PubMedCrossRefGoogle Scholar
  11. 11.
    Hu E, Levine J: Chemotherapy of malignant thymoma. Cancer 1986, 57:1101–1104.PubMedCrossRefGoogle Scholar
  12. 12.
    Quintanilla-Martinez L, Wilkins EW Jr, Choi N, Efird J, Hug E, Harris NL: Thymoma. Histologic subclassification is an independent prognostic factor. Cancer 1994, 74:606–617.PubMedCrossRefGoogle Scholar
  13. 13.
    Blossom GB, Ernstoff RM, Howells GA, Bendick PJ, Glover JL: Thymectomy for myasthenia gravis. Arch Surg 1993, 128:855–862.PubMedCrossRefGoogle Scholar
  14. 14.
    Nakahara K, Ohno K, Hashimoto J, Maeda H, Miyoshi S, Sakurai M, Monden Y, Kawashima Y: Thymoma: results with complete resection and adjuvant postoperative irradiation in 141 consecutive patients. J Thorac Cardiovasc Surg 1988, 95:1041–1047.PubMedGoogle Scholar
  15. 15.
    Wakata N, Fujioka T, Nishina M, Kawamura Y, Kobayashi M, Kinoshita M: Myasthenia gravis and invasive thymoma. A 20-year experience. Eur Neurol 1993, 33:115–120.PubMedCrossRefGoogle Scholar
  16. 16.
    Gotti G, Paladini P, Haid MM, Biagi G, Di Bisceglie M, Cioni R, Ciacci G: Late recurrence of thymoma and myasthenia gravis. Scand J Thorac Cardiovasc Surg 1995, 29:37–38.PubMedCrossRefGoogle Scholar
  17. 17.
    Fechner RE: Recurrence of noninvasive thymomas. Report of four cases and review of literature. Cancer 1969,23: 1423-1427Google Scholar
  18. 18.
    Masunaga A, Sugawara I, Yoshitake T, Nakamura H, Itoyama S, Shimoyama N, Ishidate T: A case of encapsulated noninvasive thymoma (stage I) with myasthenia gravis showing metastasis after a 2-year dormancy. Surg Today 1995, 25:369–372.PubMedCrossRefGoogle Scholar
  19. 19.
    Kumagai M, Kondou T, Handa M, Shiraishi Y, Fujimura S, Nakata T: Treatment of invasive thymoma with myasthenia gravis: a case report responsive to azathioprine and metylprednisolone. Kyobu-Geka 1990, 43:321–235.Google Scholar

Copyright information

© Springer Science+Business Media New York 1997

Authors and Affiliations

  • A. Evoli
    • 1
  • A. P. Batocchi
    • 1
  • M. T. Palmisani
    • 1
  • L. Lauriola
    • 2
  • G. B. Doglietto
    • 3
  • P. Tonali
    • 1
  1. 1.Institute of NeurologyCatholic UniversityRomaItaly
  2. 2.Institute of PathologyCatholic UniversityRomaItaly
  3. 3.Institute of SurgeryCatholic UniversityRomaItaly

Personalised recommendations