Morphology of Thymic Remnants Removed after Video-Assisted Thoracoscopic Extended Thymectomy in Patients with Thymomatous Myasthenia Gravis

  • R. Scelsi
  • M. Paulli
  • U. Gianelli
  • M. T. Ferro’
  • M. Longoni
  • L. Novellino
  • G. Pezzuoli

Summary

On a total of 67 patients with Myasthenia Gravis (MG) that had a Video-Assisted Thoracoscopic Extended Thymectomy (VATET) for removal of the thymus gland and cervical and anterior mediastinal fat tissue, 12 revealed a thymoma. Nine patients with capsulated non-invasive thymoma were studied for detection of thymic remnants in cervical and pre-pericardial fat tissue. Six out of nine subjects showed thymic remnants that in half of them demonstrated lymphoid follicular hyperplasia Immunohistochemical characterization of atrophic thymic remnants showed small T-lymphocytes (CD1a; CD3) and rare epithelial cells (EMA; Cytokeratin and LN3). Thymic remnants with lymphoid follicular hyperplasia showed germinal centres positively stained for LN1 (CDw75). Since the last alteration has been considered an important cause of failure of surgical treatment of MG, an accurate investigation and removal of all possible thymic remnants together with the proper thymus may be performed.

Keywords

Lymphoid Hyperplasia Thymic Tissue Thymus Gland Thymic Epithelial Tumor Invasive Thymoma 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1997

Authors and Affiliations

  • R. Scelsi
    • 1
  • M. Paulli
    • 1
  • U. Gianelli
    • 1
  • M. T. Ferro’
    • 2
  • M. Longoni
    • 2
  • L. Novellino
    • 2
  • G. Pezzuoli
    • 2
  1. 1.Department of Human PathologyUniversity of Pavia and Research Unit Pathology Section, I.R.C.C.S. Policlinico S. MatteoPaviaItaly
  2. 2.Division of Neurology and SurgeryPoliclinico S. Marco ZingoniaBergamoItaly

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