Accessory Molecule Expression in Human Thymomas and Thymus

  • S. Appiah-Boadu
  • J. A. Aarli
  • G. O. Skeie
  • N. E. Gilhus


Paraneoplastic MG is probably caused by sensitisation of T-cells to muscle-like epitopes presented on the neoplastic epithelial cells. Accessory molecules on antigen-presenting cells and T-cells are important for the outcome of the immunisation process. In this study, cryostat sections from 13 thymomas (11 with MG, 2 without; 10 non-invasive, 3 invasive; 3 spindle-cell, 10 polygonal-cell thymomas) and 6 normal thymuses from children were examined for the accessory molecules ICAM-1, VCAM-1, LFA-3 and CD28 using commercially available mouse monoclonal antibodies and immunoperoxidase staining.


Clonal Deletion Accessory Molecule Thymic Epithelial Tumour Normal Thymus Neoplastic Epithelial Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 1997

Authors and Affiliations

  • S. Appiah-Boadu
    • 1
  • J. A. Aarli
    • 1
  • G. O. Skeie
    • 1
  • N. E. Gilhus
    • 1
  1. 1.Department of NeurologyUniversity of BergenBergenNorway

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