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Epithelial Tumors of the Thymus pp 135–153Cite as

Thymic Tumor Progression in SV40T Transgenic Mice Model

Suggestion of Thymoma—Thymic Carcinoma Sequence

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Abstract

Large T antigen of simian virus 40 (SV40 Tag) is a nuclear protein necessary to synthesize DNA and is a potent oncogene, determining both immortalization and transformation of multiple cell types not only in culture system but also in vivo.1,2 Transgenic mice offer the potential for studying the biological effects of gene expression under physiological conditions that cannot be reproduced in culture, thus providing a system that may accurately emulate in differentiated tissues the behavior of pathological processes, such as neoplastic transformation.3 Transgenic mouse harboring SV40 Tag gene has been used as an animal model of spontaneous carcinogenesis by regulating its expression with a variety of trans-criptional elements. Choroid plexus tumor and pancreatic islet cell tumors were developed in most studies for SV40 T transgenic mice.4–10 In addition, SV40 large Tag induced a variety of neoplasm i.e., lymphoma, rhabdomyosarcoma, osteosarcoma, stomach carcinoma, hepatoma, melanoma, retinoblastoma, or hibernoma,11–21 depending on the transcriptional signals used for its expression. Although thymic hyperplasia has been reported as incidental findings in transgenic mice, there were no reports on thymic carcinoma in transgenic mice. Thymic hyperplasia was observed incidentally in some cases of transgenic mice producing choroid plexus tumors4,6,7,10 and also as a main event in transgenic mice harboring a growth hormone-releasing factor(GRF) promoter fused with simian virus 40 large T antigen22,23. Recently Teitz et al24 reported a mixed type thymoma in transgenic mice expressing SV40 Tag under the control of an erythroid specific enhancer. This is the first report on frank thymic epithelial tumor in transgenic mice expressing SV40 Tag. Besides SV40 Tag, there was a report on Thyl-myc transgenic mice developed complex lymphoid and epithelial thymic tumors.25

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Authors and Affiliations

  1. Department of Pathology, Korea Cancer Center Hospital, Seoul, Korea

    Seung-Sook Lee

  2. Department of Pathology, Seoul National University College of Medicine, Seoul, Korea

    Seung-Sook Lee, Ja-June Jang, Jeong Wook Seo, Chul Woo Kim, Sung Hoe Park & Je Geun Chi

  3. Transgenic Mice Center Cancer Research Institute and Department of Biochemistry, Seoul National University College of Medicine, Seoul, Korea

    Jeong-Sun Seo

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  1. Seung-Sook Lee
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  1. The University of Würzburg, Würzburg, Germany

    Alexander Marx  & Hans Konrad Müller-Hermelink  & 

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Lee, SS. et al. (1997). Thymic Tumor Progression in SV40T Transgenic Mice Model. In: Marx, A., Müller-Hermelink, H.K. (eds) Epithelial Tumors of the Thymus. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-0033-3_20

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  • DOI: https://doi.org/10.1007/978-1-4899-0033-3_20

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