T Cell Development in the Human Thymus

  • Bart Vandekerckhove
  • Dominique Vanhecke
  • Jean Plum

Abstract

T cell differentiation occurs in the thymus. In the thymus CD4+ helper cells and CD8αβ+ cytotoxic cells are generated under tight MHC control. Besides intrathymic T cell generation, T cells are generated outside the thymus. Peripheral expansion of mature T cells, which may or may not be antigen driven, is a major source of peripheral T cells, as well as de novo formation of T cells. Extrathymic T cell development mainly gives rise to CD4-CD8 double negative or CD8αα+TCRαβ+ and TCRγδ+ cells which reside mainly in bone marrow and epithelia.

Keywords

Severe Combine Immunodeficiency Double Positive Human Thymus Fetal Thymus Genetically Engineer Mouse 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    McCune, J. M., R. Namikawa, H. Kaneshima, L. D. Schultz, M. Lieberman, and I. L. Weissman. 1988. The SCID-hu mouse: murine model for the analysis of human hematolymphoid differentiation and function. Science 241:1632.PubMedCrossRefGoogle Scholar
  2. 2.
    Galy, A., A. Barcena, S. Verma, and H. Spits. 1993. Precursors of CD3+CD4+CD8+ in the human thymus are defined by expression of CD34. Delineation of early events in human thymic development. J. Exp. Med. 178:391.PubMedCrossRefGoogle Scholar
  3. 3.
    Fischer, A.G., L. Larson, L. K. Goff, D.E. Restall, L. Happerfield, and M. Merckenschlager. 1991. Human thymocyte development in organ cultures. Int. Immunol 3:1.CrossRefGoogle Scholar
  4. 4.
    Plum, J., M. De Smedt, M-P. Defresne, G. Leclercq, and B. Vandekerckhove. 1994. Human CD34+ fetal stem liver cells differentiate into T cells in a mouse thymic microenvironment. Blood 84:1587.PubMedGoogle Scholar
  5. 5.
    Spits, H., L. L. Lanier, and J. H. Phillips 1995 Development of human T and NK cells. Blood. 85:2654.PubMedGoogle Scholar
  6. 6.
    Barcena, A., A. H. M. Galy, J. Punnonen, M.O. Muench, D. Schols, M. Roncarolo, J. E. de Vries, and H. Spits. 1994. Lymphoid and myeloid differentiation of fetal liver CD34+ lineage-cells in human thymic organ cultures. J Exp Med 180:123.PubMedCrossRefGoogle Scholar
  7. 7.
    Galy, A., M. Travis, D. Cen, and B. Chen. 1995. Human T, B, natural killer, and dendritic cells arise from a common bone marrow progenitor cell subset. Immunity 3:459.PubMedCrossRefGoogle Scholar
  8. 8.
    Rodewald, H-R. 1995 Pathways from hematopoietic stem cells to thymocytes. Current Opinion in Immunology 7:176.PubMedCrossRefGoogle Scholar
  9. 9.
    Kisielow, P., and H. Von Boehmer. 1995. Development and selection of T cells: facts and puzzles. Adv in Immunol. 58:87.CrossRefGoogle Scholar
  10. 10.
    Vanhecke, D., G. Leclercq, J. Plum and B. Vandekerckhove. 1995. Characterization of distinct stages during differentiation of human CD69+CD3+ thymocytes and identification of thymic emigrants. J. Immunol 155:1862.PubMedGoogle Scholar
  11. 11.
    Kraft, D. L., I. L. Weissman, and E. K. Waller. 1993. Differentiation of CD3-CD4-CD8-human fetal thymocytes in vivo: characterization of a CD3-CD4+CD8-intermediate. J. Exp. Med. 178:965.CrossRefGoogle Scholar
  12. 12.
    Vanhecke, D., B. Verhasselt, V. Debacker, G. Leclercq, J. Plum and B. Vandekerckhove. 1995. Differentiation to T Helper cells in the thymus: gradual acquisition of T helper cell function by CD3+ CD4+ cells. J. Immunol 155: 1862.PubMedGoogle Scholar
  13. 13.
    Baccala, R., B. A. E. Vandekerckhove, D. Jones, D. H. Kono, M.-G. Roncarolo, A. N. Theofilopoulos. 1993. Bacterial superantigens mediate T cell deletions in the mouse severe combined immunodeficiencyhuman liver/thymus model J. Exp. Med 177: 1481.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1997

Authors and Affiliations

  • Bart Vandekerckhove
    • 1
  • Dominique Vanhecke
    • 1
  • Jean Plum
    • 1
  1. 1.Department of Clinical ChemistryMicrobiology and Immunology University HospitalGentBelgium

Personalised recommendations