Genetics and Affective Changes in Schizophrenia

  • Peter McGuffin
  • Anne E. Farmer
  • Ian Harvey
  • Maureen Williams
Conference paper

Abstract

One of the pioneers of psychiatric genetics, Luxenburger (quoted in Jaspers)(1) remarked, that for the purpose of research ‘schizophrenia’ should be regarded as no more than a useful working hypothesis. It remains essential to retain this principle especially in the current era of research when operational diagnostic criteria such as DSM-III (2) with all their proven reliability and appearance of certainty can easily mislead us into the belief that we really know what schizophrenia is. The enhancement of reliability has of course been a boon to psychiatric research, and it is scarcely surprising that the use of explicit criteria has now become virtually mandatory in respectable scientific journals when schizophrenia is the topic. But, in addition to a false sense of security and certainty, operational definitions have two other drawbacks. First, many alternative sets of criteria are available, most with proven reliability, but when a variety of definitions is employed to classify the same sample of patients there is frequently poor concordance over which subjects are or are not diagnosed suffering from schizophrenia. As Brockington et al (3) have put it, the previous state of inarticulate confusion in the diagnosis of schizophrenia has been replaced by a ‘babble of precise but differing formulations of the same concept’. The second problem is that some workers have come to question virtually any finding established before the comparatively recent introduction of operational definitions. Therefore before focussing on affective change it is worth giving some brief consideration to the genetics of schizophrenia in the context of modern diagnostic criteria.

Keywords

Manic Depressive Illness Affective Disorder Restriction Fragment Length Polymorphism Affective Illness Functional Psychos 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Jaspers K: in General Psychopathology (trans. Hamilton MW, Hoeing J) Manchester, Manchester University Press, 1962.Google Scholar
  2. 2.
    American Psychiatric Association. Diagnostic and Statistical Manual for Mental Disorders. American Psychiatric Association, Washington, DC, 1980.Google Scholar
  3. 3.
    Brockington IF, Kendell RE, Leff JP: Definitions of schizophrenia: concordance and prediction of outcome. Psychol Med 7: 387–398, 1978.CrossRefGoogle Scholar
  4. 4.
    Gottesman II, Shields J: Schizophrenia, The Epigenetic Puzzle, Cambridge, Cambridge University Press, 1982.Google Scholar
  5. 5.
    Abrams R, Taylor MA: The genetics of schizophrenia: a reassessment using modern criteria. Am J Psychiatry 140: 171–175, 1983.PubMedGoogle Scholar
  6. 6.
    Pope HG, Jonas J, Cohen BA et al: Heritability of schizophrenia. Am J Psychiatry 140: 132–133, 1983.Google Scholar
  7. 7.
    Tsuang MT, Winokur G, Crowe R: Morbidity risks of schizophrenia and affective disorders among first degree relatives of patients with schizophrenia, mania, depression and surgical conditions. Br J Psychiatry 137: 497–504, 1980.PubMedCrossRefGoogle Scholar
  8. 8.
    Feighner JP, Robins E, Guze SB et al: Diagnostic criteria for use in psychiatric research. Arch Gen Psychiatry 26: 57–63, 1972.PubMedCrossRefGoogle Scholar
  9. 9.
    Guze SB, Cloninger CR, Martin RL et al: A follow up and family study of schizophrenia. Arch Gen Psychiatry 40: 1273–1276, 1983.PubMedCrossRefGoogle Scholar
  10. 10.
    Baron M, Gruen R, Kane J et al: Modern research criteria and the genetics of schizophrenia. Am J Psychiatry 142: 679–701, 1985.Google Scholar
  11. 11.
    Gottesman II, Shields J: Schizophrenia and Genetics: a Twin Study Vantage Point. London, Academic Press, 1972.Google Scholar
  12. 12.
    McGuffin P, Farmer AE, Gottesman II, et al: Twin concordance for operationally defined schizophrenia. Confirmation of familiality and heritability. Arch Gen Psychiatry 41: 541–545, 1984.PubMedCrossRefGoogle Scholar
  13. 13.
    Farmer AE, McGuffin P, Gottesman II: Twin concordance for DSM-III schizophrenia: scrutinizing the validity of the definition. Arch Gen Psychiatry 44: 634–641, 1987.PubMedCrossRefGoogle Scholar
  14. 14.
    Spitzer RL, Endicott J, Robins E: Research Diagnostic Criteria, Instrument no. 58. New York State Psychiatric Institute, New York, 1978.Google Scholar
  15. 15.
    Schneider K: Clinical Psychopathology. Translated by Hamilton MW, Grune and Stratton, London and New York, 1959.Google Scholar
  16. 16.
    Tienari P, Sorri A, Lahti J, et al: Interaction of genetic and psychosocial factors in schizophrenia. Acta Psychiatr Scand [supp.] 319: 19–30, 1985.Google Scholar
  17. 17.
    Kendler KS, Gruenberg AM: An independent antigen of the Danish adoption study of schizophrenia IV. The pattern of psychiatric illness as defined by DSM-II in adoptees and relatives. Arch Gen Psychiatry 41: 555–564, 1984.PubMedCrossRefGoogle Scholar
  18. 18.
    Kety SS, Rosenthal D, Wender PH et al: Mental illness in the biological and adoptive families of individuals who have become schizophrenic. Behaviour Genetics 6: 219–225, 1976.CrossRefGoogle Scholar
  19. 19.
    Kraepelin E: Manic Depressive Insanity and Paranoia. ( Translated by Barclay RM) E & S Livingstone, Edinburgh 1922.Google Scholar
  20. 20.
    Slater E: Genetical causes of schizophrenia symptoms. Monatsschrift Fine Psychiatrie and Neurologie 113: 5058, 1947 (reprinted in Man, Mind and Heredity, ed. Shields J, Gottesman I I ).Google Scholar
  21. 21.
    Odegaard O: The multifactorial theory of inheritance in predisposition to schizophrenia, in Genetic Factors in Schizophrenia, Edited by Kaplan AR, Thomas CC, Springfield, Illinois 256–275, 1972.Google Scholar
  22. 22.
    Kendell RE: Other functional psychoses, in Companion to Psychiatric Studies, 4th Ed., Edited by Kendell RE, Zealley AK, Churchill Livingston, Edinburgh, 1988.Google Scholar
  23. 23.
    Shields J: Unpublished data, 1977.Google Scholar
  24. 24.
    Stuart E, Kamakura N, Der G: How depressing life is–life-long morbidity risk for depressive disorder in the general population. J Affective Dis 7: 109–122, 1984.CrossRefGoogle Scholar
  25. 25.
    Tsuang MT, Dempsey GM, Dvoredsky A et al: A family history of schizo-affective disorder. Biological Psychiatry 12: 331–338, 1977.PubMedGoogle Scholar
  26. 26.
    Gershon ES, Hamovit J, Guroff JJ et al: A family study of schizoaffective bipolar I, bipolar II, unipolar and normal control probands. Arch Gen Psychiatry 39: 1157 1167, 1982.Google Scholar
  27. 27.
    Shopsin B, Mendelweicz J, Suslac L et al: Genetics of affective disorders: II Morbidity risk and genetic transmission. Neuropsychobiology 2: 28–36, 1976.PubMedCrossRefGoogle Scholar
  28. 28.
    Angst J, Felder W, Lohmeyer B: Schizoaffective psychoses heterogenous? Results of a genetic investigation. II. J Affective Dis 1: 155–165, 1979.CrossRefGoogle Scholar
  29. 29.
    Mendlewicz J, Linkowski P, Guroff JJ et al: Color blindness linkage to bipolar manic depressive illness: new evidence. Arch Gen Psychiatry 36: 142–147, 1979.CrossRefGoogle Scholar
  30. 30.
    Scharfetter C, Nusperli M: The group of schizophrenias, schizoaffective psychoses and affective disorders. Schizophr Bull 6: 586–591, 1980.PubMedCrossRefGoogle Scholar
  31. 31.
    Kendler KS, Heath AC, Martin NG et al: Symptoms of anxiety and depression in a volunteer twin population. The aetiologic role of genetic and environmental factors. Arch Gen Psychiatry 43: 213–221, 1986.PubMedCrossRefGoogle Scholar
  32. 32.
    Angst J, Felder W, Lohmeyer B: Schizo-affective disorders: Results of genetic investigation: I. J Affective Dis 1: 139–153, 1979.CrossRefGoogle Scholar
  33. 33.
    Elsasser G: Die Nachkommen Geisteskranker Elternpaare. ed Thieme G, Stuttgart, 1952.Google Scholar
  34. 34.
    Fischer M, Gottesman II: A study of offspring of parents both hospitalized for psychiatric disorders, in The Social Consequences of Psychiatric Illness, Edited by Robins LN, Clayton PJ, Wing JR, Brunner/Mazel, New York, 1980.Google Scholar
  35. 35.
    Perris C: A study of cycloid psychosis. Acta Psychiatr Scand Suppl 253, 1974.Google Scholar
  36. 36.
    McCabe MS: Reactive psychoses. A clinical and genetic investigation. Acta Psychiatrica Scandinavica Supplementum 259, 1975.Google Scholar
  37. 37.
    Mitsuda H: Clinical Genetics in Psychiatry, Igaku Shoin, Tokyo, 1967.Google Scholar
  38. 38.
    Kaij L: Atypical endogenous psychosis. Report on a family. Br J Psychiatry 113: 415–422, 1967.PubMedCrossRefGoogle Scholar
  39. 39.
    Walinder J: Recurrent familial psychosis of the schizo-affective type. Acta Psychiatrica Scandinavica 48: 274–283, 1972.PubMedCrossRefGoogle Scholar
  40. 40.
    Cohen SM, Allen MG, Pollen W et al: Relationship of schizo-affective psychosis to manic-depressive psychosis and schizophrenia. Findings in 15, 909 veteran pairs. Arch Gen Psychiatry 26: 539–546, 1972.Google Scholar
  41. 41.
    Bertelsen A: Genetics studies in schizophrenia and schizoaffective disorders, in A Genetic Perspective for Schizophrenic and Related Disorders, Edited by Smeraldi E, Milan, 1988.Google Scholar
  42. 42.
    McGuffin P, Reveley A, Holland A: Identical triplets: non-identical psychosis? Br J Psychiatry 140: 1–6, 1982.PubMedCrossRefGoogle Scholar
  43. 43.
    Dalby JT, Morgan D, Lee ML: Single case study. Schizophrenia and mania in identical twin brothers. J Nery Ment Dis 174: 304–308, 1986.CrossRefGoogle Scholar
  44. 44.
    Falconer DS: The inheritance of liability to certain disease, estimated from the incidence among relatives. Annals of Human Genetics 29: 51–76, 1965.CrossRefGoogle Scholar
  45. 45.
    James J: Frequency in relatives for an all-or-none trait. Annals of Human Genetics 35: 47–49, 1971.PubMedCrossRefGoogle Scholar
  46. 46.
    Reich T, James W, Morris CA: The use of multiple thresholds in determining the mode of transmission of semi-continuous traits. Annals of Human Genetics 36: 163–184, 1972.PubMedCrossRefGoogle Scholar
  47. 47.
    Morton NE: Outline of Genetic Epidemiology, Basel, Karger, 1982.Google Scholar
  48. 48.
    O’Rourke DH, Gottesman II, Suarez BK et al: Refutation of the single locus model in the aetiology of schizophrenia. Amer J Human Genetics 33: 630–649, 1982.Google Scholar
  49. 49.
    Reich T, Cloninger CR, Wette R et al: The use of multiple thresholds and segregation analysis in analyzing the phenotypic heterogeneity of multifactorial traits. Annals of Human Genetics 42: 371, 1979.PubMedCrossRefGoogle Scholar
  50. 50.
    McGuffin P, Stuart E: Genetic markers in schizophrenia. Human Heredity 36: 65–88, 1986.PubMedCrossRefGoogle Scholar
  51. 51.
    Donis-Kellar H, Green P, Helms C et al: A genetic linkage map of the human genome. Cell 51: 319–337, 1987.CrossRefGoogle Scholar
  52. 52.
    Egeland JA, Gerhard DS, Pauls DL et al: Bipolar affective disorder linked to DNA markers on chromosome 11. Nature 325: 783–787, 1987.PubMedCrossRefGoogle Scholar
  53. 53.
    Mendlewicz J, Simon P, Sevy S et al: Polymorphic DNA marker and X chromosome and manic depression. Lancet ii: 1230–1232, 1987.Google Scholar
  54. 54.
    Baron M, Risch N, Hamburger R et al: Genetic linkage between X chromosome markers and manic depression. Nature 326: 806–808, 1987.Google Scholar
  55. 55.
    Hodgkinson S, Sherrington R, Gurling HAD et al: Molecular genetic evidence for heterogeneity in manic depression. Nature 325: 805–806, 1987.PubMedCrossRefGoogle Scholar
  56. 56.
    Gershon ES, Mendlewicz J, Gaspar M et al: A collaborative study of genetic linkage of bipolar manic depressive illness and red/green colour blindness. Acta Psychiatr Scand 61: 319–338, 1980.PubMedCrossRefGoogle Scholar
  57. 57.
    McGuffin P, Murray RM, Reveley AM: Genetic influences on the functional psychoses. Br Med Bull 43: 531–556, 1987.PubMedGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1989

Authors and Affiliations

  • Peter McGuffin
    • 1
    • 2
    • 3
  • Anne E. Farmer
    • 1
    • 2
    • 3
  • Ian Harvey
    • 1
    • 2
    • 3
  • Maureen Williams
    • 1
    • 2
    • 3
  1. 1.University of Wales College of MedicineCardiffWales
  2. 2.University of Wales College of MedicineLondonEngland
  3. 3.King’s CollegeUniversity of LondonUK

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