Dendritic Cell Based Therapy of Cancer

  • Michael T. Lotze
  • Michael Shurin
  • Ian Davis
  • Andrew Amoscato
  • Walter J. Storkus
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 417)


The recent identification of techniques both in the mouse and in man to culture dendritic cells which could be adoptively trasnferred for therapy have opened new avenues of research. We have applied both synthetic and natural or acid eluted peptides from the tumor cell surface in order to elicit effective antitumor responses in vivo and in vitro in murine tumor models as well as in vivo in human preclinical trials. Based on these studies, we will soon initiate a human clinical trial utilizing human dendritic cells pulsed with synthetic melanoma derived peptides presented by HLA-A2. The delivery of genes into human dendritic cells to constitutively express cytokines, costimulatory molecules or tumor antigens represents another potential approach to the development of dendritic cell based therapies.


Dendritic Cell Peptide Vaccine FLT3 Ligand Tumor Peptide Control Dendritic Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 1997

Authors and Affiliations

  • Michael T. Lotze
    • 1
    • 2
  • Michael Shurin
    • 1
    • 2
  • Ian Davis
    • 1
    • 2
  • Andrew Amoscato
    • 1
    • 2
  • Walter J. Storkus
    • 1
    • 2
  1. 1.Departments of Surgery,and Molecular Genetics and BiochemistryUniversity of Pittsburgh School of MedicinePittsburghUSA
  2. 2.Biological Therapeutics DivisionUniversity of Pittsburgh Cancer InstitutePittsburghUSA

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