Abstract
Dendritic cells (DC) are regarded as professional antigen presenting cells capable of efficiently stimulating T cells. In addition, in vitro stimulation of naive T cells can only be achieved efficiently by dendritic cells (DC) (1–3). After antigen administration, DC are the only cells bearing immunogenic fragments and capable of stimulating specific naive T cells in vitro (4, 5). Furthermore, B cells seem dispensable in T cell-dependent immune response in vivo (6, 7). However, as yet there is no direct evidence that DC are absolutely required for the generation of an in vivo primary immune response. A possible way to approach this question is to use an animal model in which DC are depleted. There are yet no natural animal model of a genetic deficit of DC. Recently, a generated relB knock out mice have a DC deficit in lymphoid tissues. However, secondary lymphoid tissues loss their normal structure, with a strong atrophy of splenic white pulp and lymph nodes, rendering complicated the use of this model to study the role of DC in immune response (8, 9).
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Salomon, B., Leenen, P.J.M., Klatzmann, D. (1997). Immune Response in Dendritic Cell Depleted Mice. In: Ricciardi-Castagnoli, P. (eds) Dendritic Cells in Fundamental and Clinical Immunology. Advances in Experimental Medicine and Biology, vol 417. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-9966-8_90
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DOI: https://doi.org/10.1007/978-1-4757-9966-8_90
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