Positive and Negative Regulation of Dendritic Cell Function by Lipopolysaccharide in Vivo

  • Thibaut De Smedt
  • Bernard Pajak
  • Eric Muraille
  • Jacques Urbain
  • Oberdan Leo
  • Muriel Moser
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 417)

Abstract

There is evidence that induction of primary immune responses in vitro and in vivo relies on the presentation of antigen by dendritic cells1. The unique property of DC to sensitize naive T lymphocytes may depend on a specialization of function over time that results in a reciprocal regulation of the capacity to process antigens and to activate T cells. Fresh DC process antigens and generate high levels of peptides/MHC complexes, whereas cultured DC have lost this capacity but have gained the property to prime T lymphocytes. This process of maturation occurs spontaneously in culture and correlates with increased expression of class II, B7-1 and B7-2 costimulatory molecules2–6.

Keywords

Dendritic Cell Marginal Zone SCID Mouse Cell Area White Pulp 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1997

Authors and Affiliations

  • Thibaut De Smedt
    • 1
  • Bernard Pajak
    • 1
  • Eric Muraille
    • 1
  • Jacques Urbain
    • 1
  • Oberdan Leo
    • 1
  • Muriel Moser
    • 1
  1. 1.Département de Biologie MoléculaireUniversité Libre de BruxellesRhode-Saint-GenèseBelgium

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