Role of B7 Costimulation in the Induction of T and B Cell Responses by Dendritic Cells in vivo

  • Laurence Lespagnard
  • Pascal Mettens
  • Jacques Urbain
  • Muriel Moser
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 417)


The adjuvant properties of dendritic cells have been amply demonstrated. A single injection of splenic DC, which have been pulsed extracorporeally with antigen, induces primary T (1) and B (2) cell responses in vivo. Recent reports have shown that tumor-bearing animals or patients can be immunized against their own tumors by injecting autologous DC pulsed with tumor associated antigens (3, 4). In vivo priming using elements of the immune system avoids the toxic effect of external adjuvants and leads to an antigen-specific, anamnestic immune response.


Dendritic Cell Keyhole Limpet Hemocyanin Adjuvant Property Individual Seron Human Gamma Globulin 
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Copyright information

© Springer Science+Business Media New York 1997

Authors and Affiliations

  • Laurence Lespagnard
    • 1
  • Pascal Mettens
    • 1
  • Jacques Urbain
    • 1
  • Muriel Moser
    • 1
  1. 1.Laboratoire de Physiologie AnimaleUniversité Libre de BruxellesRhode-Saint-GenèseBelgium

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