Abstract
The adjuvant properties of dendritic cells have been amply demonstrated. A single injection of splenic DC, which have been pulsed extracorporeally with antigen, induces primary T (1) and B (2) cell responses in vivo. Recent reports have shown that tumor-bearing animals or patients can be immunized against their own tumors by injecting autologous DC pulsed with tumor associated antigens (3, 4). In vivo priming using elements of the immune system avoids the toxic effect of external adjuvants and leads to an antigen-specific, anamnestic immune response.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Inaba K, Metlay JP, Crowley MT and Steinman RM. J Exp Med 1990; 172: 631.
Sornasse T, Flamand V, De Becker G, Bazin H, Tielemans F, Thielemans K, Urbain J, Leo O and Moser M. J Exp Med 1992; 175: 15.
Flamand V, Sornasse T, Thielemans K, Demanet C, Bakkus M, Bazin H, Tielemans F, Leo O, Urbain J and Moser M. Eur J Immunol 1994; 24: 605.
Zitvogel L, Mayordomo JI, Tjandrawan T, DeLeo AB, Clarke MR, Lotze MT and Storkus WJ. J Exp Med 1996; 183: 87.
Hsu FJ, Benike C, Fagnoni F, Liles TM, Czerwinski D, Taidi B, Engelman EG and Levy R. Nature Medicine 1996; 2: 52.
Larsen CP, Ritchie SC, Hendrix R, Linsley PS, Hathcock KS, Hodes RJ, Lowry RP and Pearson TC.. I Immunol 1994; 152: 5208.
De Smedt T, Pajak B, Muraille E, Lespagnard L, Heinen E, De Baetselier P. Urbain J. Leo O and Moser M. J Exp Med 1996; 184: 1.
Ronchese F, Hausmann B, Hubele S and Lane P.1 Exp Med 1994; 179: 809.
Lane P, Burdet C, Hubele S, Scheidegger D, Müller U. Mc Connell F and Kosco-Vilbois M. J Exp Med 1994; 179: 819.
Freeman GJ, Boussiotis VA, Anumanthan AJ, Bernstein GM, Ke XY, Rennert PD, Gray GS, Gribben JG and Nadler LM. Immunity 1995; 2. 523.
Kuchroo VK, Das MP, Brown JA, Ranger AM, Zamvill SS, Sobel RA, Weiner HL, Nabavi N and Glimcher LH. Cell 1995; 80: 707.
Quill H and Schwartz RH. Jlmmunol 1987; 138: 3704.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1997 Springer Science+Business Media New York
About this chapter
Cite this chapter
Lespagnard, L., Mettens, P., Urbain, J., Moser, M. (1997). Role of B7 Costimulation in the Induction of T and B Cell Responses by Dendritic Cells in vivo . In: Ricciardi-Castagnoli, P. (eds) Dendritic Cells in Fundamental and Clinical Immunology. Advances in Experimental Medicine and Biology, vol 417. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-9966-8_87
Download citation
DOI: https://doi.org/10.1007/978-1-4757-9966-8_87
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4757-9968-2
Online ISBN: 978-1-4757-9966-8
eBook Packages: Springer Book Archive