Disappearance of the Antigen Exchanging Ability of FDC Induced by Repeated Antigen Injections

  • Toshiko Yoshida
  • Kenichi Takaya
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 417)


Follicular dendritic cells (FDCs) retain the antigen on their membranes usually in the form of antigen-antibody complexes which disappear slowly with time (I). FDC is unable to retain the antigen for a long time, and replaces the old antigens with new ones, even if the antigen is the same (2). Recently FDC was reported to degenerate in individuals manifesting persistent generalized lymphadenopathy after infection with human immunodeficiency virus (HIV). It has been considered that the antigen retention is indispensable to form the FDC network. In this case FDC retained the antigens but the network was disrupted (3). It may be due to the incomplete antigen retaining ability of FDC for the practice of its role.


Human Immunodeficiency Virus Cortical Area Germinal Center Repeated Injection Follicular Dendritic Cell 
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Copyright information

© Springer Science+Business Media New York 1997

Authors and Affiliations

  • Toshiko Yoshida
    • 1
  • Kenichi Takaya
    • 1
  1. 1.Second Department of Anatomy Faculty of MedicineToyama Medical and Pharmaceutical UniversityToyamaJapan

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