Disappearance of the Antigen Exchanging Ability of FDC Induced by Repeated Antigen Injections
Follicular dendritic cells (FDCs) retain the antigen on their membranes usually in the form of antigen-antibody complexes which disappear slowly with time (I). FDC is unable to retain the antigen for a long time, and replaces the old antigens with new ones, even if the antigen is the same (2). Recently FDC was reported to degenerate in individuals manifesting persistent generalized lymphadenopathy after infection with human immunodeficiency virus (HIV). It has been considered that the antigen retention is indispensable to form the FDC network. In this case FDC retained the antigens but the network was disrupted (3). It may be due to the incomplete antigen retaining ability of FDC for the practice of its role.
KeywordsHuman Immunodeficiency Virus Cortical Area Germinal Center Repeated Injection Follicular Dendritic Cell
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