Absence of Follicular Dendritic Cells (FDC) in Mutant Mice with Deficient TNF/Lymphotoxin (LT) Signaling

  • Michel Le Hir
  • Hans-Pietro Eugster
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 417)


FDC occur as clusters in the B cell areas (follicles) of lymph nodes, spleen, tonsil and Peyers patches. Anatomically these clusters appear as a locally specialized compartment of a cellular meshwork that spans the secondary lymphoid tissues. FDC are mostly considered to differentiate from the fibroblast-like cells forming that meshwork (l-6). However there is experimental support for the alternative view that FDC might originate from the bone marrow (2,7,8). It is possible to distinguish FDC by ultrastructural criteria from other cells of the reticular meshwork (4,6,9). Identification by light microscopy requires specific markers, e. g. antibodies against complement receptors (CR) (10). The monoclonal antibody FDC-M1 detects FDC in the mouse (11). Binding of immune complexes, e. g. peroxidase-anti-peroxidase, in vivo as well as in tissue sections constitutes a further criterion for identification of FDC (12).


Germinal Center Complement Receptor Follicular Dendritic Cell Severe Combine Immunodeficiency Postnatal Development 
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Copyright information

© Springer Science+Business Media New York 1997

Authors and Affiliations

  • Michel Le Hir
    • 1
  • Hans-Pietro Eugster
    • 2
  1. 1.Institute of Anatomy of the University of Zürich-IrchelZürichSwitzerland
  2. 2.Institute of Toxicology of the University and ETH ZürichSchwerzenbachSwitzerland

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