Infection of Human Thymic Dendritic Cells with HIV-1 Induces the Release of a Cytotoxic Factor(s)

  • Dominique Bergeron
  • Sylvie Beaulieu
  • Marielle Lafontaine
  • Isabelle Courchesne
  • Eric A. Cohen
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 417)


Lymphoid organs have been reported to represent the major site for the establishment and the propagation of human immunodeficiency virus (HIV-l) (1). HIV-1 infection is characterized by a permanent high-level of viral replication associated with a high-level turnover of CD4+ T cells (2). The late stages of the disease are characterized by a progressive depletion of CD4+ T cells that eventually lead to the development of the acquired immune deficiency syndrome (AIDS). A variety of direct and indirect mechanisms have been proposed to account for the decline of the CD4+ T cells (3). Among them, inappropriate activation of apoptosis, a programmed cell death process, has been proposed to contribute to the CD4+ T cell depletion (4). HIV-induced apoptotic cell death has been demonstrated not only in vitro but also in infected individuals and is now considered to be a major mechanism of HIV-mediated cell death (5–7).


Cell Subset Severe Combine Immunodeficiency Programme Cell Death Process Thymic Cell Cytotoxic Factor 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Pantaleo, G., and A. S. Fauci. 1995. Annu. Rev. Immunol. 13: 487–512.PubMedCrossRefGoogle Scholar
  2. 2.
    Ho, D. D., A. U. Neumann, A. S. Perelson, W. Chen, J. M. Leonard, and M. Markowitz. 1995. Nature 373: 123.PubMedCrossRefGoogle Scholar
  3. 3.
    Levy, J. A. 1993. Microbiol. Rev. 57: 183–289.PubMedGoogle Scholar
  4. 4.
    Ameison, J. C., and A. Capron. 1991. Immunol. Today 12: 102.CrossRefGoogle Scholar
  5. 5.
    Finkel, T. H., G. Tudor-Williams, N. K. Banda, M. F. Cotton, T. Curiel, C. Monks, T. W. Baba, R. M. Ruprecht, and A. Kupfer. 1995. Nature Medicine 1: 129.PubMedCrossRefGoogle Scholar
  6. 6.
    Muro-Cacho, C. A., G. Pantaleo, and A. S. Fauci. 1995. J. Immunol. 154: 5555.PubMedGoogle Scholar
  7. 7.
    Oyaizu, N., and S. Pahwa. 1995. J. Clin. Immunol. 15: 217.PubMedCrossRefGoogle Scholar
  8. 8.
    Beaulieu, S., A. Kessous, D. Landry, S. Montplaisir, D. Bergeron, and E. A. Cohen. 1996. Virology 222: 214.PubMedCrossRefGoogle Scholar
  9. 9.
    Schnittman, S.M., S. M. Denning, J. J. Greenhouse, J. S. Justement, M. Baseler, J. Kurtzberg, B. F. Haynes, and A. S. Fauci. 1990. Proc. Natl. Acad. Sci. USA 87: 7727.CrossRefGoogle Scholar
  10. 10.
    Valentin, H., M.-T. Nugeyre, F. Vuillier, L. Boumsell, M. Schmid, F. Barré-Sinoussi, and R. A. Pereira. 1994. Virology 68: 3041.Google Scholar
  11. 11.
    Joshi, V. V., J. M. Oleske, S. Saad, C. Gadol, E. Connor, R. Bobila, and A. B. Minnefor. 1986. Arch. Pathol. Lab. Med. 110: 837.PubMedGoogle Scholar
  12. 12.
    Mano, H., and J.-C. Chermann. 1991. AIDS Res. Hum. Retroviruses 7: 83.PubMedGoogle Scholar
  13. 13.
    Aldrovandi, G. M., G. Feuer, L. Gao, B. Jamieson, M. Kristeva, I. S. Y. Chen, and J. A. Zack. 1993. Nature 363: 732–736.PubMedCrossRefGoogle Scholar
  14. 14.
    Bonyhadi, M. L., L. Rabin. S. Salimi, D. A. Brown, J. Kosek, J. M. McCune, and H. Kaneshima. 1993. Nature 363: 728.PubMedCrossRefGoogle Scholar
  15. 15.
    Su, L., H. Kaneshima, M. Bonyhadi, S. Salimi, D. Kraft, L. Rabin, and J. M.McCune. 1995. Immunity 2: 25.PubMedCrossRefGoogle Scholar
  16. 16.
    Beaulieu, S., D. Landry, D. Bergeron, E. A. Cohen, and S. Montplaisir. 1995. J. Immunol. Methods 180: 225.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1997

Authors and Affiliations

  • Dominique Bergeron
    • 1
  • Sylvie Beaulieu
    • 1
  • Marielle Lafontaine
    • 1
  • Isabelle Courchesne
    • 1
  • Eric A. Cohen
    • 1
  1. 1.Département de microbiologie et immunologieUniversité de MontréalMontréalCanada

Personalised recommendations