Immortalized Cell Lines with Dendritic Morphology Derived from Mice Lacking Both Type I and Type II Interferon Receptors Present MHC II Restricted Antigen to T Cells and Induce Mixed Leukocyte Reactions

  • R. Nunez
  • M. Ackermann
  • M. Suter
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 417)


Interferons (IFN) are potent regulators of the immune response. They modulate host defense against infections and induce growth inhibition of tumors. Two types of IFN families have been described. The type I IFN family includes α, β and ω IFN, the type II IFN is represented by IFNγ as the only member. IFN molecules bind to specific receptors present on the cell surface. It is thought that the binding of IFN with its specific receptor induces the plethora of functions associated with IFN (6).


Dendritic Morphology Immortalize Cell Line Derive Cell Line FACS Buffer Antigen Uptake 
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Copyright information

© Springer Science+Business Media New York 1997

Authors and Affiliations

  • R. Nunez
    • 1
  • M. Ackermann
    • 1
  • M. Suter
    • 1
  1. 1.Institute for Virology Veterinary FacultyUniversity of ZürichSwitzerland

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