Cutaneous Dendritic Cells Promote Replication of Immunodeficiency Viruses

  • Melissa Pope
  • Sarah Frankel
  • Ralph Steinman
  • David Elmore
  • David Ho
  • Preston Marx
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 417)

Abstract

The body surfaces [such as the linings of the vagina, cervix, anus, and oropharynx] that are potentially exposed to HIV-1 during sexual and perinatal transmission, are similar to the skin in histology and dendritic cell [DC] content. Since large amounts of fresh skin are more readily available, the skin-derived leukocytes have been used as a model for the mucosal leukocytes to study their interaction with virus and potential roles in viral pathogenesis.

Keywords

Mucosal Associate Lymphoid Tissue Perinatal Transmission Free Virus Fresh Skin Tonsillar Crypt 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1997

Authors and Affiliations

  • Melissa Pope
    • 1
  • Sarah Frankel
    • 2
  • Ralph Steinman
    • 1
  • David Elmore
    • 3
  • David Ho
    • 4
  • Preston Marx
    • 4
  1. 1.Laboratory of Cellular Physiology and ImmunologyThe Rockefeller UniversityNew YorkUSA
  2. 2.The Armed Forces Institute of PathologyAIDS DivisionUSA
  3. 3.Charles River Biomedical Resources Foundation Inc.HoustonUSA
  4. 4.The Aaron Diamond AIDS Research CenterThe Rockefeller UniversityNew YorkUSA

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