Abstract
Differential cytokine production (Thl versus Th2) by CD4+ T cells during an immune response plays an important role in determining the biological implications of the response. Th1 cells are characterized by the dominance of IFN-γ production while Th2 cells produce predominantly 1L-4. It is now well established that IL-12 is essential for the priming of Thl cytokine secreting T cells1 while IL-4 is critical in the priming of Th2 cytokine secreting T cells2. While it has been suggested that CD1 specific NK1.1 CD4+ T cells in the spleen3, or CD4- CD8-, TCRαβ+ T cells restricted by MHC class I4 might be the potential sources of IL-4 during primary immune responses, these have not been clearly demonstrated.
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Liu, L., Rich, B.E., Inobe, J., Chen, W., Weiner, H.L. (1997). A Potential Pathway of Th2 Development during Primary Immune Response. In: Ricciardi-Castagnoli, P. (eds) Dendritic Cells in Fundamental and Clinical Immunology. Advances in Experimental Medicine and Biology, vol 417. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-9966-8_61
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DOI: https://doi.org/10.1007/978-1-4757-9966-8_61
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