Dramatic Numerical Increase of Functionally Mature Dendritic Cells in FLT3 Ligand-Treated Mice

  • Eugene Maraskovsky
  • Bali Pulendran
  • Ken Brasel
  • Mark Teepe
  • Eileen R. Roux
  • Ken Shortman
  • Stewart D. Lyman
  • Hilary J. Mckenna
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 417)


Dendritic cells (DC) are rare hematopoietic-derived cells that are predominantly found in the T-cell-dependent areas of lymphoid tissue, as well as other tissues of the body1. These cells express high levels of class I and class II major histocompatibility complex (MHC) proteins, CD11c2, the mannose-receptor like protein DEC2053,4 and adhesion and costimulatory molecules1. A substantial proportion of DC express CD8α as a homodimer5. DC specialize in processing and presenting foreign and self antigens to induce immunity1 or tolerance6,7. The lineage derivation of DC remains controversial, but there is growing evidence that DC can be subdivided into myeloid-derived8–17 and lymphoid-derived populations17–19.


Dendritic Cell Major Histocompatibility Complex Spleen Cell Keyhole Limpet Hemocyanin Mature Dendritic Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 1997

Authors and Affiliations

  • Eugene Maraskovsky
    • 1
  • Bali Pulendran
    • 1
  • Ken Brasel
    • 1
  • Mark Teepe
    • 1
  • Eileen R. Roux
    • 1
  • Ken Shortman
    • 3
  • Stewart D. Lyman
    • 2
  • Hilary J. Mckenna
    • 1
  1. 1.Department of ImmunobiologyImmunex CorporationSeattleUSA
  2. 2.Department of Molecular GeneticsImmunex CorporationSeattleUSA
  3. 3.The Walter and Eliza Hall Institute of Medical ResearchMelbourneAustralia

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