IL-10 Prevents the Generation of Dendritic Cells from CD14+ Blood Monocytes, Promotes the Differentiation to Mature Macrophages and Stimulates Endocytosis of FITC-dextran

  • P. Allavena
  • L. Piemonti
  • D. Longoni
  • S. Bernasconi
  • A. Stoppacciaro
  • L. Ruco
  • A. Mantovani
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 417)

Abstract

Dendritic cells (DC) constitute an heterogeneous system of leukocytes specialized in antigen (Ag) capture, processing and presentation to immunocompetent cells1,2. Their hematopoietic differentiation lineage of DC has not clearly been defined. At least some DC are closely related to the mononuclear phagocyte system, but there is also evidence of DC belonging to a separate differentiation pathway1,2. Recently large quantities of DC have been differentiated from monocyte-enriched PBMC using GM-CSF and IL-43,4. We have demonstrated that IL-4 can be substituted with IL-13, with identical results.

Keywords

Dendritic Cell Blood Monocyte Mannose Receptor Mononuclear Phagocyte System Dendritic Cell Differentiation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1997

Authors and Affiliations

  • P. Allavena
    • 1
  • L. Piemonti
    • 1
  • D. Longoni
    • 1
  • S. Bernasconi
    • 1
  • A. Stoppacciaro
    • 2
  • L. Ruco
    • 2
  • A. Mantovani
    • 1
    • 3
  1. 1.Department of Immunology and Cell Biology“Mario Negri” InstituteMilanoItaly
  2. 2.Department of Expimental Medince and PathologyUniversity of RomeRomeItaly
  3. 3.Division of General PathologyUniversity of BresciaBresciaItaly

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