Abstract
We recently identified a cell surface protein (gp40) that is homologous to human EpCAM, a putative homophilic adhesion molecule, and that is abundantly expressed by some murine dendritic cells (including Langerhans cells) and in certain epithelia (1). While characterizing various dendritic cells with regard to gp40 expression, we determined that the pleiotropic cytokine TGFβ;1 was uniquely able to induce cell surface expression of gp40 on dendritic cells propagated from murine bone marrow in fetal calf serum- and GM-CSF-supplemented media. To determine whether or not this finding was potentially physiologically significant, we studied Langerhans cells in TGFβ1 null mice that had previously been generated and described by Kulkarni, Karlsson and coworkers (2).
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
I. T. A. Borkowski, A. J. Nelson, A. G. Farr, M. C. Udey, Eue J. Immunol. 26, 110–114 (1996).
A. B. Kulkarni, et al., Proc. Natl. Acad. Sci. 90, 770–774 (1993).
M. B. Sporn, A. B. Roberts, J. Cell Biol. 119, 1017–1021 (1992).
D. M. Kingsley, Genes Devel. 8, 133–146 (1994).
M. M. Shull, et al., Nature 359, 693–699 (1992).
M. C. Dickson, et al., Development 121, 1845–1854 (1995).
A. G. Geiser, et al., Proc. Natl. Acad. Sci. 90, 9944–9948 (1993).
H. Dang, et al., J. Immunol. 155, 3205–3212 (1995).
L. Yaswen, et al., Blood 87, 1439–1445 (1996).
Y. Vodovotz, et al., J. Exp. Med. 183, 2337–2342 (1996).
A. B. Glick, et al., Genes Devel. 8, 2429–2440 (1994).
X.-J. Wang, et al., Proc. Natl. Acad. Sci. , (In press).
H. Strobl, et al., J. Irnmunol. 157, 1499–1507 (1996).
K. Schwarzenberger, M. C. Udey, J. Invest. Dermato1. 106, 553–558 (1996).
A. B. Glick, et al., Proc. Natl. Acad. Sci. 90, 6076–6080 (1993).
M. S. Gruschwitz, O. P. Hornstein, J. Invest. Dermatol. 99, 114–116 (1992).
F. Granucci, et al., Eue J. Immunol. 24, 2522–2526 (1994).
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1997 Springer Science+Business Media New York
About this chapter
Cite this chapter
Borkowski, T.A. et al. (1997). Langerhans Cells in the TGFβ1 Null Mouse. In: Ricciardi-Castagnoli, P. (eds) Dendritic Cells in Fundamental and Clinical Immunology. Advances in Experimental Medicine and Biology, vol 417. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-9966-8_50
Download citation
DOI: https://doi.org/10.1007/978-1-4757-9966-8_50
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4757-9968-2
Online ISBN: 978-1-4757-9966-8
eBook Packages: Springer Book Archive