B7-2+ Low Density APCS are as Effective as B7-2 Small Resting B Cells in Inducing Specific Unresponsiveness to Minor Histocompatibility (miH) Antigen(S) in Vivo

  • Masanori Niimi
  • Mary-Anne Rawsthorne
  • Peter J. Morris
  • Kathryn J. Wood
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 417)


Dendritic cells and small resting B cells are thought to be immunogenic and tolerogenic in the periphery, respectively, as dendritic cells but not resting B cells can provide costimulatory signal(s) (1–7). Fuchs and Matzinger demonstrated that resting B cells but not dendritic cells could induce tolerance to H-Y mismatched skin grafts (8). We have extended this study by comparing the ability of dendritic cells and resting B cells to induce tolerance to cardiac grafts mismatched for miH antigen(s).


Skin Graft Costimulatory Signal Operational Tolerance Cardiac Graft John Radcliffe Hospital 
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Copyright information

© Springer Science+Business Media New York 1997

Authors and Affiliations

  • Masanori Niimi
    • 1
  • Mary-Anne Rawsthorne
    • 1
  • Peter J. Morris
    • 1
  • Kathryn J. Wood
    • 1
  1. 1.Nuffield Department of SurgeryUniversity of OxfordOxfordUK

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