Abstract
Several groups originally established the importance of GM-CSF and TNFα in the generation of dendritic cells from CD34+ precursors (1–3), and most investigators have used cord blood as the starting source. Studies from our laboratories confirmed the essential role of these cytokines in supporting bone marrow CD34+-derived dendritic cell growth and differentiation, and the addition of c-kit-ligand facilitated more detailed phenotypic and functional characterization of the dendritic cell progeny than had previously been possible (4).
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References
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Szabolcs, P., Ciocon, D.H., Moore, M.A.S., Young, J.W. (1997). Growth and Differentiation of Human Dendritic Cells from CD34+ Progenitors. In: Ricciardi-Castagnoli, P. (eds) Dendritic Cells in Fundamental and Clinical Immunology. Advances in Experimental Medicine and Biology, vol 417. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-9966-8_3
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DOI: https://doi.org/10.1007/978-1-4757-9966-8_3
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