Abstract
Several studies have shown that substantial numbers of functional dendritic cells (DC) can be generated in vitro from human CD34+ progenitor cells upon culture with the two cytokines GM-CSF and TNFα.1,2,3 More recent data suggest that at least two in vitro differentiation pathways for the development of DC seem to exist.4,5,6 One pathway gives rise to Langerhans (LC) type DC. Phenotypically, this pathway follows the route CD34+ to CD1a+ to CD1a+/Lag+ and does not involve a CD14+ monocytoid intermediate cell stage.5
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Strobl, H. et al. (1997). TGF-β1 Dependent Generation of LAG+ Dendritic Cells from CD34+ Progenitors in Serum-Free Medium. In: Ricciardi-Castagnoli, P. (eds) Dendritic Cells in Fundamental and Clinical Immunology. Advances in Experimental Medicine and Biology, vol 417. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-9966-8_26
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DOI: https://doi.org/10.1007/978-1-4757-9966-8_26
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