Langerhans Cells Require Signals from Both Tumour Necrosis Factor α and Interleukin 1β for Migration

  • M. Cumberbatch
  • R. J. Dearman
  • I. Kimber
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 417)


Tumour necrosis factor α (TNF-α) is considered to play an important role in the initiation of epidermal Langerhans cell (LC) migration during the induction phase of cutaneous immune responses.1 Intradermal injection of mice with homologous recombinant TNF-α stimulates both the migration away from the epidermis of a proportion of LC and the subsequent accumulation in draining lymph nodes of dendritic cells (DC).2,3 Moreover, treatment of mice with a neutralizing anti-TNF-α antibody has been shown to inhibit markedly the increase in lymph node DC associated with exposure to skin sensitizing chemicals,4,5 ultraviolet B light,6 or the skin irritant sodium lauryl sulphate.4


Drain Lymph Node Intradermal Injection Normal Rabbit Serum Dendritic Cell Migration Epidermal Sheet 
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Copyright information

© Springer Science+Business Media New York 1997

Authors and Affiliations

  • M. Cumberbatch
    • 1
  • R. J. Dearman
    • 1
  • I. Kimber
    • 1
  1. 1.Zeneca Central Toxicology LaboratoryMacclesfield CheshireUK

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