The Liver Sinusoids as a Specialized Site for Blood-Lymph Translocation of Rat Dendritic Cells
The fate as well as the significance of blood dendritic cells (DC) is not yet completely resolved. Some may migrate to the splenic white pulp1 and other immature DC may reach the epithelial tissues to become resident DC. When particulates are injected intravenously, relatively immature particle-laden DC appear in the peripheral lymph draining the liver2. The results suggest that the rat DC lineage may be selectively recruited to the liver after intravenous injection of particulates and that they subsequently translocate from the liver vasculature to the hepatic lymph. The present study was performed to demonstrate the migration pathway of blood DC and the existence of specialized vasculature for DC, the liver sinusoids.
KeywordsLiver Perfusate Immature Dendritic Cell Mature Dendritic Cell Liver Sinusoid Blood Dendritic Cell
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