An Approach to Targeted Therapy: Synthesis and Biological Activity of Hydrophobic and Hydrophilic Enkephalin Analogues
The mechanisms whereby opioid peptides (naturally occuring peptides with opiate — like biological properties) activate processes on their target receptors are still at an early stage of exploration. The aim of receptor research is to purify and isolate receptor glycoproteins or glycolipids in order to further implement the knowledge of the physicochemical aspects involved in the interaction of opioids with their receptor.
KeywordsOpioid Receptor Opioid Peptide Wheat Germ Agglutinin Antinociceptive Activity Soybean Lecithin
Unable to display preview. Download preview PDF.
- Behnam, B. A. and Deber, C.M., 1984, Evidence for a Folded Conformation of Methionine-and Leucine-Enkephalin in a Membrane Environment, J. Biol. Chem., 259: 14.935.Google Scholar
- Garcia-Anton, J. M., Sole, N., and Reig, F., 1985, Synthesis of Hydrophobic Enkephalin amides, Int. J. Peptide Protein Res., 26: 591.Google Scholar
- Rodriguez, R. E., Sole, N., Reig, F., 1986, Analgesic Effects of (D-Met2-Pro5-NH2) — Enkephalin Analogues in Rats, Life Sci., (in press).Google Scholar