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Eledoisin and Ceruletide, Two Naturally Occurring Peptide Drugs of Nonmammalian Origin

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Part of the NATO ASI Series book series (NSSA,volume 125)

Abstract

Poor absorption and metabolic instability usually make the parenteral route of administration the sole practical one for peptide drugs. Restricted permeability of the blood-brain barrier to peptides may constitute another drawback. The availability of suitable delivery systems could possibly extend the field of application of these drugs. On the other hand, technical problems and uncertain forecast of return of investment often actually limit the studies in this area. This was also the case with eledoisin and ceruletide, two naturally occurring peptide drugs developed in our laboratories as a result of a long and continuous collaboration with Prof. V. Erspamer in the field of biologically active peptides of nonmammalian origin.

Keywords

  • Paralytic Ileus
  • Peptide Drug
  • Keratoconjunctivitis Sicca
  • Nasal Absorption
  • Amphibian Skin

These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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de Castiglione, R. (1986). Eledoisin and Ceruletide, Two Naturally Occurring Peptide Drugs of Nonmammalian Origin. In: Davis, S.S., Illum, L., Tomlinson, E. (eds) Delivery Systems for Peptide Drugs. NATO ASI Series, vol 125. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-9960-6_29

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  • DOI: https://doi.org/10.1007/978-1-4757-9960-6_29

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