Delivery Systems for Recombinant Methionyl Human Growth
The advent of recombinant DNA technology has lead to an increased interest in convenient, effective pharmaceutical dosage forms for polypeptide drugs. It is well known that there are many obstacles to delivery of these compounds by conventional dosage forms. Large molecular weight, solubility problems, suseptibility to enzymatic degradation, sensitivity to pH and temperature, and short in vivo half life are some of the problems that must be confronted. For drugs with such complex biological activities as most therapeutic polypeptides one of the biggest obstacles to development of delivery systems is lack of information on the mechanism of action of the drug.
KeywordsDosage Form Bile Salt Cocoa Butter Human Growth Hormone Sodium Salicylate
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