The Transdermal Route for the Delivery of Peptides and Proteins

  • B. W. Barry
Part of the NATO ASI Series book series (NSSA, volume 125)


Little work has been reported in the literature on the percutaneous delivery of peptides and proteins. This chapter therefore aims to survey the problems associated with the use of the intact skin as a pathway of entry of drugs into the systemic circulation, and to attempt to predict some of the difficulties likely to arise if the penetrants are peptides. However, at the outset we can deduce with some confidence that the efficient, controlled delivery of intact peptides and proteins to the systemic circulation via the transdermal route will prove to be the most challenging project to date in skin permeation technology.


Stratum Corneum Hair Follicle Sweat Gland Sebaceous Gland Percutaneous Absorption 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Barry, B. W., 1983, “Dermatological Formulations: Percutaneous Absorption”, Dekker, New York and Basel.Google Scholar
  2. Bronough, R. L., and Maibach, H. L., 1985, “Percutaneous Absorption”, Dekker, New York and Basel.Google Scholar
  3. Brooks, F. L., Hugo, W. B., and Denyer, S. P., 1982, Transformation of betamethasone-17-valerate by skin microflora, J. Pharm Pharmacol., 34: 61P.CrossRefGoogle Scholar
  4. Chien, Y. W., 1982, “Novel Drug Systems”, Dekker, New York and Basel.Google Scholar
  5. Denyer, S. P., Hugo, W. B., and O’Brien, M., 1984, Metabolism of glyceryl trinitrate by skin staphylococci, J. Pharm. Pharmacol., 36: 61P.CrossRefGoogle Scholar
  6. Denyer, S. P., Guy, R. H., Hadgraft, J., and Hugo, W. B., 1985, The microbial degradation of topically applied drugs, J.Pharm.Pharmacol., 37: 89.CrossRefGoogle Scholar
  7. Dugard, P. H., 1977, Skin permeability theory in relation to percutaneous absorption in toxicology, Adv. Mod. Toxicol., 4: 525.Google Scholar
  8. Elias, P. M., 1981, Epidermal lipids, membranes, and keratinization, Int.J.Dermatol., 20: 1.PubMedCrossRefGoogle Scholar
  9. Flynn, G. L., 1979, Topical drug absorption and topical pharmaceutical systems, in: “Modern Pharmaceutics”, G. S. Banker and C. T. Rhodes, eds., Dekker, New York and Basel.Google Scholar
  10. Gardner, M. L. G., 1984, Intestinal assimilation of intact peptides and proteins from the diet — a neglected field? Biol.Rev., 59: 289.PubMedCrossRefGoogle Scholar
  11. Gardner, M. L. G., 1985, Production of pharmacologically active peptides from food in the gut, in: “Food and the Gut”, J. O. Hunter and V. A. Jones, eds., Bailliere Tindall, London.Google Scholar
  12. Gibaldi, M., 1984, “Biopharmaceutics and Clinical Pharmacokinetics”, 3rd ed., Lea & Febiger, Philadelphia.Google Scholar
  13. Gibaldi, M., and Perrier, D., 1975, “Pharmacokinetics”, Dekker, New York and Basel.Google Scholar
  14. Higuchi, T., 1977, Pro-drug, molecular structure and percutaneous delivery, in: “Design of Biopharmaceutical Properties Through Prodrugs and Analogs”, B. Roche, ed., American Pharmaceutical Association, Washington.Google Scholar
  15. Guy, R. H. and Hadgraft, J., 1984, Pharmacokinetics of percutaneous absorption and concurrent metabolism, Int.3.Pharm., 20: 43.CrossRefGoogle Scholar
  16. Idson, B., 1971, Percutaneous absorption, in: “Absorption Phenomena”, J. L. Rabinowitz and R. M. Myerson, eds., Wiley (interscience), New York.Google Scholar
  17. Idson, B., 1975, Percutaneous absorption, J.Pharm.Sci., 64: 901.PubMedCrossRefGoogle Scholar
  18. Katz, M., 1973, Design of topical drug products: pharmaceutics, in: “Drug Design”, E. J. Ariens, ed., Academic Press, New York.Google Scholar
  19. Katz, M., and Poulsen, B. J., 1971, Absorption of drugs through the skin, in: “Handbook of Experimental Pharmacology”, Vol.28, Pt.1, B. B. Brodie and J. Gillette, eds., Springer-Verlag, New York.Google Scholar
  20. Marty, J.-P., Guy, R. H., and Maibach, H. I., 1985, Percutaneous penetration as a method of delivery to muscle and other tissues, in: “Percutaneous Absorption”, R. L. Bronaugh and H. I. Maibach, eds., Dekker, New York and Basel.Google Scholar
  21. Noonan, P. K., and Wester, R. K., 1985, Cutaneous metabolism of xenobiotics, in: “Percutaneous Absorption”, R. L. Bronaugh and H. I. Maibach, eds., Dekker, New York and Basel.Google Scholar
  22. Poulsen, B. J., 1973, Design of topical drug products: biopharmaceutics in: “Drug Design”, E. J. Ariens, ed., Academic Press, New York.Google Scholar
  23. Schaefer, H., Zesch, A., and Stuttgen, G., 1982, “Skin Permeability”, Springer-Verlag, New York.CrossRefGoogle Scholar
  24. Scheuplein, R. J., 1972, Properties of the skin as a membrane, Adv.Biol.Skin., 12: 125.PubMedGoogle Scholar
  25. Scheuplein, R. J., 1978, The skin as a barrier, Skin permeation, Site variation in diffusion and permeability, in: “The Physiology and Pathophysiology of the Skin”, A. Jarrett, ed., Academic Press, New York and London.Google Scholar
  26. Uda, Y., and Yamada, M., 1984 European Patent 0 127 426 A1.Google Scholar
  27. Ulashchik, V. S., and Boitsov, L. N., 1977, On the physiocochemical principles and quantitative mechanisms of aminoacid electrophoresis, Vopr.Kurortol.Fizioter.Lech.Fiz.Kul’t., 4: 58.Google Scholar
  28. Wagner, J.G., 1975, “Fundamentals of Clinical Pharmacokinetics”, Drug Intelligence Publications, Hamilton, Illinois.Google Scholar
  29. Wester, R. C. and Noonan, P. K., 1980, Relevance of animal models for percutaneous absorption, Int J. Pharm., 7: 99.CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1986

Authors and Affiliations

  • B. W. Barry
    • 1
  1. 1.Postgraduate School of PharmacyUniversity of BradfordBradfordUK

Personalised recommendations