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Controlled Delivery of Nafarelin, An Agonistic Analogue of LHRH, From Microspheres of Poly (D, L Lactic-Co-Glycolic) Acid

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Part of the book series: NATO ASI Series ((NSSA,volume 125))

Abstract

The present rapid expansion of activity in development of peptide and protein drug compounds has provided a major thrust for development of novel technology for their delivery. These compounds have typically very low oral bioavailability (although this elusive goal is sufficiently attractive for it to remain an active area of exploration).

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References

  • Anik, S.T., McRae, G.I., Nerenberg, C., Worden, A., Foreman, J., Hwang, J-Y., Kushinsky, S., Jones, R.E., and Vickery, B., 1984, Nasal Absorption of Nafarelin Acetate, the Decapeptide [D-Nal(2)6]LHRH, in Rhesus Monkeys I, J. Pharm. Sci., 73: 684.

    Article  PubMed  CAS  Google Scholar 

  • Anik, S.T., Benjamin, E.J., Maskiewicz, R., McRae, G.I., Nerenberg, C., Hwang-Felgner, J., Schneider, J., Worden, A., and Foreman, J., 1986, Nasal Absorption of Nafarelin Acetate in Rhesus Monkeys II: Effect of Formulation Variables. Manuscript in Preparation.

    Google Scholar 

  • Anik, S.T., and Hwang, J-Y., 1983, Adsorption of D-Nal(2)6LHRH, a Decapeptide, onto Glass and Other Surfaces. Int. J. Pharm., 16: 81.

    Article  Google Scholar 

  • Beck, L.R., Pope, V.Z., Flowers, C.E. Jr., Cowsar, D.R., Tice, T.R., Lewis, D.H., Dunn, R.L., Moore, A.B., and Gilley, R.M., 1983, Poly(DL-lactide-co-glycolide)/Norethisterone Microcapsules: An Injectable Biodegradable Contraceptive, Biol. of Rep., 28: 186.

    Article  CAS  Google Scholar 

  • Beck, L.R., Cowsar, J.R., Lewis, D.H., Cosgrove, R.J., Riddle, C.T., Lowry, S.L., and Epperly, T., 1979. A New Long-Acting Injectable Microcapsule System for the Administration of Progesterone, Fert. Ster., 31:545.

    CAS  Google Scholar 

  • Hoffman, P.G., Henzl, M.R., Chaplin, M.D., and Nerenberg, C.A., 1986, Phase I and II Studies: Clinical Development of Nafarelin Acetate, Adv. Contracep., In Press.

    Google Scholar 

  • Kent, J.S., Sanders, L.M., Tice, T.R., and Lewis, D.H., 1984, Microencap-sulation of the Peptide Nafarelin Acetate for Controlled Release, in “Long-Acting Contraceptive Delivery Systems”, G.I. Zatuchni, A. Goldsmith, J.D. Shelton, and J.D. Sciarra, eds., Harper and Row, Philadelphia.

    Google Scholar 

  • Mason, N.S., Miles, C.S., and Sparks, R.E., 1981, Hydrolytic Degradation of Poly DL-(lactide), Polym. Sci. Technol., 14: 279.

    CAS  Google Scholar 

  • Sanders, L.M., Kent, J.S., McRae, G.I., Vickery, B.H., Tice, T.R., and Lewis, D.H., 1984, Controlled Release of a Leuteinizing Hormone — Releasing Hormone Analogue from Poly (d, l-lactide-co-glycolide) Microspheres, J. Pharm. Sci., 73: 1294.

    Article  PubMed  CAS  Google Scholar 

  • Sanders, L.M., McRae, G.I., Vitale, K.M., and Kell, B.A., Controlled Delivery of an LHRH Analogue from Biodegradable Injectable Microspheres, 1985, J. Cont. Rel., 2:187.

    Google Scholar 

  • Vickery, B.H., and McRae, G.I., 1984, LHRH Agonists for Control of Female Fertility: Primate Studies, in: “LHRH and its Analogs. Contraceptive and Therapeutic Applications”, B.H. Vickery, J.J. Nestor Jr., E.S.E. Hafez, eds., MTP Press, Lancaster.

    Chapter  Google Scholar 

  • Vickery, B.H., 1986, Comparison of the Potential for Therapeutic Utilities with GNRH Agonists and Antagonists, Endocrine Reviews, 7: 115.

    Article  PubMed  CAS  Google Scholar 

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© 1986 Springer Science+Business Media New York

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Sanders, L.M., Vitale, K.M., Mc Rae, G.I., Mishky, P.B. (1986). Controlled Delivery of Nafarelin, An Agonistic Analogue of LHRH, From Microspheres of Poly (D, L Lactic-Co-Glycolic) Acid. In: Davis, S.S., Illum, L., Tomlinson, E. (eds) Delivery Systems for Peptide Drugs. NATO ASI Series, vol 125. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-9960-6_10

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  • DOI: https://doi.org/10.1007/978-1-4757-9960-6_10

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4757-9962-0

  • Online ISBN: 978-1-4757-9960-6

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