Gene Products of Cytomegalovirus and Their Immunologic Significance
The protein composition of CMV is quite complex. The 230-kilobase genome has the coding capacity for over 200 proteins, each of which may be subject to post-translational modification by cleavage, phosphorylation, glycosylation, or sulfation. Our understanding of the immunologic structure of CMV has improved greatly in the last few years as a result of the development of monoclonal antibodies and recombinant gene expression technologies. The CMV gene products have been grouped by size in a recent review by Landini and Michelson (1988). The immune responses that occur following CMV infection and the importance of specific viral proteins in inducing these responses have also been reviewed recently (Rasmussen, 1989). In this chapter I first review what is known about the protein and glycoproteins of CMV. The gene products that are associated with immunologic activities are then described. The focus is on human immune responses; however, studies in animal models or with nonhuman CMV strains are included when they illustrate principles that may be important for subsequent studies in humans (see also Chapters 6 and 7).
KeywordsDense Body Envelope Glycoprotein Human Seron Viral Glycoprotein Specific Viral Protein
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