Inhibition of Cytochrome P-450 Enzymes

  • Paul R. Ortiz de Montellano
  • Norbert O. Reich


The catalytic cycle of cytochrome P-450 (see Chapter 7) traverses three steps that are particularly vulnerable to inhibition: (1) the binding of substrates, (2) the binding of molecular oxygen subsequent to the first electron transfer, and (3) the catalytic step in which the substrate is actually oxidized. This chapter focuses on inhibitors that act at one of these three steps. Inhibitors that act at other steps in the catalytic cycle, such as quinones that interfere with the electron supply to the hemeprotein by accepting electrons directly from cytochrome P-450 reductase,1–3 are not discussed here.


Enzyme Inactivation Microsomal Cytochrome Iron Porphyrin Carbene Complex Piperonyl Butoxide 
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Copyright information

© Springer Science+Business Media New York 1986

Authors and Affiliations

  • Paul R. Ortiz de Montellano
    • 1
  • Norbert O. Reich
    • 1
  1. 1.Department of Pharmaceutical Chemistry, School of PharmacyUniversity of CaliforniaSan FranciscoUSA

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