The Structural Approach to Metabolic Control Analysis II: Geometrical Aspects

  • Jean-Pierre Mazat
  • Christine Reder
  • T. Letellier
Part of the NATO ASI Series book series (NSSA, volume 190)


In the general framework of metabolic control theory (Kacser & Bums, 1973; Heinrich & Rapoport, 1974), Reder (1986, 1988) has described a general method that provides a way of analysing the sensitivity of a metabolic system to perturbation of the environment or of its internal state. This method extends and generalizes the matrix method proposed by Fell & Sauro (1985) and Westerhoff & Chen (1984).


Metabolic Network Structural Approach Logarithmic Derivative Geometrical Aspect Control Coefficient 
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Copyright information

© Springer Science+Business Media New York 1990

Authors and Affiliations

  • Jean-Pierre Mazat
    • 1
  • Christine Reder
    • 2
  • T. Letellier
    • 1
  1. 1.Institut de Biochimie Cellulaire et de NeurochimieCentre National de la Recherche Scientifique et Université de Bordeaux IIBordeaux CedexFrance
  2. 2.UER de Mathématique et InformatiqueUniversité de Bordeaux ITalence CedexFrance

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