History and Original Thoughts on the Control Theoretic Approach

  • Joseph Higgins
Part of the NATO ASI Series book series (NSSA, volume 190)


I have been asked to present some historical background on the early theory of metabolic control; I am pleased to do so. I guess I was asked to do this because to some, at least, I am considered a grandfather of the field. I am not sure how I came to be a grandfather without ever being a father. Yet let that be, for I accept the accolade with sincere appreciation even though I think it partly, if not wholly, apocryphal. But if there are grandfathers, there must also be great-grandfathers and even great-great-grandfathers lurking in the woods. So with no small concern about the validity of such terms, I shall nevertheless address this history in those terms. Hopefully some grandchildren will be reading too. But let me note at the outset that I am not a scientific historian and that I present this history from a rather personal view.


Reflection Coefficient Metabolic Control Pyruvate Kinase Ordinary Derivative Master Reaction 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 1990

Authors and Affiliations

  • Joseph Higgins
    • 1
  1. 1.Department of Biochemistry and BiophysicsUniversity of PennsylvaniaPhiladelphiaUSA

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