Coupled Reactions and Channelling: their Role in the Control of Metabolism

Keleti, Tamás

doi:10.1007/978-1-4757-9856-2_22

Tamás Keleti²

Part of the book series: NATO ASI Series ((NSSA,volume 190))

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3 Citations

Abstract

Control analysis was developed for describing the regulatory properties of metabolic pathways (Savageau, 1972, 1976; Kacser & Burns, 1973, 1979; Kacser, 1983; Heinrich & Rapoport, 1973, 1974aó, 1983; Heinrich et al, 1977). The more effective the control, the more elastic the metabolic pathway, i.e more able to respond to changes in external conditions. Kacser (1983) has suggested the idea of “molecular democracy” to characterize each enzyme in a metabolic process as an autonomous entity and the control as a sort of linear superposition of the effects of the individual enzymes. The milieu of this “molecular society” is a bulk aqueous solution with non-interacting enzymes and non-compartmentalized metabolites homogeneously dispersed therein. The links in such a metabolic network are the intermediate metabolite pools.

With great sadness, we announce that Tamás Keleti died suddenly on the 4th October 1989

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Institute of Enzymology, Biological Research Center, Hungarian Academy of Sciences, Budapest, H-1502, Hungary
Tamás Keleti

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Keleti, T. (1990). Coupled Reactions and Channelling: their Role in the Control of Metabolism. In: Cornish-Bowden, A., Cárdenas, M.L. (eds) Control of Metabolic Processes. NATO ASI Series, vol 190. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-9856-2_22

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