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Control of Metabolic Processes pp 183–194Cite as

Metabolic Control by the Cyclic Cascade Mechanism: a Study of E. coli Glutamine Synthetase

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Part of the book series: NATO ASI Series ((NSSA,volume 190))

Abstract

The cyclic cascade model was developed through detailed studies on the regulation of Escherichia coli glutamine synthetase. This enzyme catalyses the biosynthesis of glutamine and since the amide nitrogen atom of glutamine is a preferred nitrogen source for the biosynthesis of virtually all amino acids, purine and pyrimidine nucleotides, NAD and glucosamine-6-phosphate, it is rigorously regulated in bacteria which synthesize their own amino acids. [For reviews, see Stadtman & Ginsburg (1974), Stadtman & Chock (1978), Chock et al., (1980), Rhee et al., (1985).]

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Authors and Affiliations

  1. Laboratory of Biochemistry, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland, 20892, USA

    P. Boon Chock, Sue Goo Rhee & Earl R. Stadtman

Authors
  1. P. Boon Chock
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  2. Sue Goo Rhee
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  3. Earl R. Stadtman
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Editor information

Editors and Affiliations

  1. Center for Biochemistry and Molecular Biology—CNRS, Marseille, France

    Athel Cornish-Bowden  & María Luz Cárdenas  & 

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Chock, P.B., Rhee, S.G., Stadtman, E.R. (1990). Metabolic Control by the Cyclic Cascade Mechanism: a Study of E. coli Glutamine Synthetase. In: Cornish-Bowden, A., Cárdenas, M.L. (eds) Control of Metabolic Processes. NATO ASI Series, vol 190. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-9856-2_14

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  • DOI: https://doi.org/10.1007/978-1-4757-9856-2_14

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4757-9858-6

  • Online ISBN: 978-1-4757-9856-2

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