What Should a Theory of Metabolic Control Offer to the Experimenter?

  • Daniel E. Atkinson
Part of the NATO ASI Series book series (NSSA, volume 190)


In his preparations for this symposium, Athel Comish-Bowden mentioned a desire to present control theory to experimentalists in such a way as to persuade them that their subject could advance more rapidly with more attention to theoretical ideas. He is also inviting some experimentalists to indicate what they think a useful theory should offer, and has asked me to attempt to assess in the final chapter the extent to which the others have offered experimentalists a workable approach to metabolic control.


Kinetic Order Metabolic Regulation Metabolic Model Regulatory Enzyme Elasticity Coefficient 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Atkinson, D. E. (1977) Cellular Energy Metabolism and its Regulation, Academic Press, New YorkGoogle Scholar
  2. Atkinson, D. E., Clarke, S. G., Rees, D. C. & Barkley, D. S. (1987) Dynamic Models in Biochemistry, Benjamin/Cummings, Menlo Park, CaliforniaGoogle Scholar
  3. Boscâ, L. & Corredor, C. (1984) Trends Biochem. Sci. 9, 372–373CrossRefGoogle Scholar
  4. Burns, J. A., Cornish-Bowden, A., Groen, A. K., Heinrich, R., Kacser, H., Porteous, J. W., Rapoport, S. M., Rapoport, T. A., Stucki, J. W., Wanders, R. J. A. & Westerhoff, H. V. (1985) Trends Biochem. Sci. 10, 16CrossRefGoogle Scholar
  5. Crabtree, B. & Newsholme, E. A. (1985) Curr. Topics Cell. Reg. 25, 21–76Google Scholar
  6. Crabtree, B. & Newsholme, E. A. (1987) Trends Biochem. Sci. 12, 4–12CrossRefGoogle Scholar
  7. Darwin, C. (1861) in More Letters of Charles Darwin (Darwin, F., ed., 1903) 1, September 18, 1861, Murray, LondonGoogle Scholar
  8. Groen, A. K., Wanders, R. J. A., Westerhoff, H. V., van der Meer, R. & Tager, J. M. (1982) J. Biol. Chem. 257, 2754–2757PubMedGoogle Scholar
  9. Heinrich, R. & Rapoport, T. A. (1974) Eur. J. Biochem. 42, 89–95PubMedCrossRefGoogle Scholar
  10. Heinrich, R., Rapoport, S. M. & Rapoport, T. A. (1977) Prog. Biophys. Molec. Biol. 32, 1–82CrossRefGoogle Scholar
  11. Hill, A. V. (1910) J. Physiol. (Lond.) 40, iv-vii Google Scholar
  12. Kacser, H. & Burns, J. A. (1973) Symp. Soc. Exp. Biol. 27, 65–104PubMedGoogle Scholar
  13. Kacser, H. & Burns, J. A. (1981) Genetics 7, 630–666Google Scholar
  14. Kacser, H. & Porteous, J. W. (1987) Trends Biochem. Sci. 12, 5–14CrossRefGoogle Scholar
  15. Mazat, J.-P. & Jean-Bart, E. (1988) Biochemical Education 16, 28–30CrossRefGoogle Scholar
  16. Monod, J., Wyman, J. & Changeux, J.-P. (1965) J. Mol. Biol. 12, 88–118PubMedCrossRefGoogle Scholar
  17. Popper, K. (1959) The Logic of Scientific Discovery, Hutchinson, London (translated from Logik der Forschung, Vienna, 1934 )Google Scholar
  18. Salter, M., Knowles, R. G. & Pogson, C. I. (1986) Biochem. J. 234, 635–647PubMedGoogle Scholar
  19. Sauro, H. M. & Fell, D. A. (1987) Biochem. Soc. Trans. 15, 234–235Google Scholar
  20. Savageau, M. A. (1976) Biochemical Systems Analysis: A Study of Function and Design in Molecular Biology, Addison-Wesley, Reading, MassachusettsGoogle Scholar
  21. Westerhoff, H. V. & Kell, D. B., Biotechnol. Bioeng. 30, 101–107, 1987PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1990

Authors and Affiliations

  • Daniel E. Atkinson
    • 1
  1. 1.Department of Chemistry and BiochemistryUniversity of CaliforniaLos AngelesUSA

Personalised recommendations