Abstract
While exploring the biological effects of i.v. — administered hCRF in volunteers, we observed a marked ventilatory stimulation which was obviously provoked by hCRF (Oppermann et al., 1985). In a controlled study we demonstrated a highly significant ventilatory analeptic effect in 13 healthy male and female subjects. This effect was dose-dependent, minute volume and tidal volume rose markedly. Breathing frequency was not found to be altered (Nink et al., 1988 in press).
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Nink, M., Huber, I., Krauze, U., Lehnert, H. (1988). Influence of the Neurohormones: Human Corticotropin Releasing Factor (hCRF), Thyrotropin Releasing Hormone (TRH), Adrenocorticotropic Hormone (ACTH) on Ventilation in Humans. In: Karczewski, W.A., Grieb, P., Kulesza, J., Bonsignore, G. (eds) Control of Breathing During Sleep and Anesthesia. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-9850-0_29
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DOI: https://doi.org/10.1007/978-1-4757-9850-0_29
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