Skip to main content
SpringerLink
Log in
Book cover

Control of Breathing and Its Modeling Perspective pp 397–400Cite as

A Model for the Contribution of Lung Receptors to the Control of Breathing: Positive and Negative Feed-Backs

  • Chapter

  • 118 Accesses

Abstract

Experiments in dogs in which pulmonary and systemic circulations were controlled separately have shown that minute ventilation (̇VE) increased when the CO2 content of pulmonary arterial blood was increased, while systemic arterial PCO2 was kept constant. Similarly, ̇VE also increased when pulmonary blood flow was increased at constant PCO2. These responses were abolished after bilateral vagal transection10, 20. We present two positive feed-backs which may account for the increases in ̇VE observed in these experiments. Further, a negative feed-back is presented controlling the CO2 related off-switch of inspiration.

This is a preview of subscription content, log in via an institution.

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   169.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   219.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD   219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Averill, D.B., W.E. Cameron and A.J. Berger, Monosynaptic excitation of dorsal medullary respiratory neurons by slowly adapting pulmonary stretch receptors. J. Neurophysiol. 52: 771–785 (1984).

    PubMed  CAS  Google Scholar 

  2. Averill, D.B., W.E. Cameron and A.J. Berger, Neural elements subserving pulmonary stretch receptor-mediated facilitation of phrenic motoneurons. Brain Res. 346: 378–382 (1985).

    Article  PubMed  CAS  Google Scholar 

  3. Bishop, B., Abdominal muscles and diaphragm activities and cavity pressures in pressure breathing. J. Appl. Physiol. 18: 37–42 (1963).

    PubMed  CAS  Google Scholar 

  4. Bishop, B. and H. Bachofen, Comparison of neural control of diaphragm and abdominal muscle activities in the cat. J. Appl. Physiol. 32: 798–805 (1972).

    PubMed  CAS  Google Scholar 

  5. Clark, F.J. and C. von Euler, On the regulation of depth and rate of breathing. J. Physiol. 222: 267–295 (1972).

    PubMed  CAS  Google Scholar 

  6. Coleridge, H.M., Coleridge, J.C.G. & Banzett, R.B., II. Effect of CO2 on afferent vagal endings in the canine lung. Respir. Physiol. 34: 135–151 (1978).

    Article  PubMed  CAS  Google Scholar 

  7. Cunningham, D.J.C., Howson, M.G., Metias, E.F. & Petersen, E.S., Patterns of breathing in response to alternating patterns of alveolar carbon dioxide pressures in man. J. Physiol. 376: 31–45 (1986).

    PubMed  CAS  Google Scholar 

  8. DiMarco, A.F., C. von Euler, J.R. Romaniuk and Y. Yamamoto, Positive feedback facilitation of external intercostal and phrenic inspiratory activity by pulmonary stretch receptors. Acta Physiol. Scand. 113: 375–386 (1981).

    Article  PubMed  CAS  Google Scholar 

  9. Euler, C. von and T. Trippenbach, Excitability changes of the inspiratory ‘off-switch’ mechanism tested by electrical stimulation in the nucleus parabrachialis in the cat. Acta Physiol. Scand. 97: 175–188 (1976).

    Article  Google Scholar 

  10. Green, F.G. and M.I. Sheldon, Ventilatory changes associated with changes in pulmonary blood flow in dogs. J. Appl. Physiol.: Respirat. Environ. Exercise Physiol. 54: 997–1002 (1983).

    CAS  Google Scholar 

  11. Grinten, C.P.M. van der, W.R. de Vries, S.C.M. Luijendijk, Vagal modification of inspiratory activity during pressure breathing in cats. Europ. Respir. J. 2 Suppl 5: 311S (1989).

    Google Scholar 

  12. Grinten C.P.M. van der, W.R. de Vries, S.C.M. Luijendijk, Vagal amplification of phrenic activity at different levels of ventilation in spontaneously breathing cats. Europ. J. Appl. Physiol. 62: 49–55 (1991).

    Article  Google Scholar 

  13. Grinten C.P.M. van der, E. Schoute, W.R. de Vries, S.C.M. Luijendijk, Conventional versus slug CO2 loading and the control of breathing in anaesthetized cats. J. Physiology 445: 487–498 (1992).

    Google Scholar 

  14. Henke, K.G., M. Sharratt, D. Pegelow and J.A. Dempsey, Regulation of end-expiratory lung volume during exercise. J. Appl. Physiol. 64: 135–146 (1988)

    PubMed  CAS  Google Scholar 

  15. Hering, E., Die Selbststeuerung der Athmung durch den Nervus vagus. Sitzungsber. Akad. Wiss. Wien 57: 672–677 (1868).

    Google Scholar 

  16. Luijendijk, S.C.M., Within-breath PCO2 levels in the airways and at the pulmonary stretch receptor sites. J. Appl. Physiol.: Respirat., Environ. Exercise Physiol. 55: 1333–1340 (1983).

    CAS  Google Scholar 

  17. Martin, J.G. and A. De Troyer, The behavior of the abdominal muscles during inspiratory mechanical loading. Respir. Physiol. 50: 63–73 (1982).

    Article  PubMed  CAS  Google Scholar 

  18. Mustafa, M.E.K.Y. and M.J. Purves, The effect of CO2 upon discharge from slowly adapting stretch receptors in the lungs of rabbits. Respir. Physiol. 16: 197–212 (1972).

    Article  PubMed  CAS  Google Scholar 

  19. Pack, A.I., R.G. DeLaney and A.P. Fishman, Augmentation of phrenic neural activity by increased rates of lung inflation. J. Appl. Physiol.: Respirat. Environ. Exercise Physiol. 50: 149–161 (1981).

    CAS  Google Scholar 

  20. Sheldon M.I. and F.G. Green, Evidence for pulmonary CO2 chemosensitivity: effects on ventilation. J. Appl. Physiol.: Respirat. Environ. Exercise Physiol. 52: 1192–1197 (1982).

    CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Pulmonology, University Hospital Maastricht, P.O. Box 5800, 6202 AZ, Maastricht, The Netherlands

    C. P. M. van der Grinten & S. C. M. Luijendijk

Authors
  1. C. P. M. van der Grinten
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. S. C. M. Luijendijk
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Chiba University, Chiba, Japan

    Yoshiyuki Honda

  2. Yamagata University, Yonezawa, Japan

    Yoshimi Miyamoto

  3. Tokyo Women’s Medical College, Tokyo, Japan

    Kimio Konno

  4. St. George’s Hospital Medical School, London, UK

    John G. Widdicombe

Rights and permissions

Reprints and permissions

Copyright information

© 1992 Springer Science+Business Media New York

About this chapter

Cite this chapter

van der Grinten, C.P.M., Luijendijk, S.C.M. (1992). A Model for the Contribution of Lung Receptors to the Control of Breathing: Positive and Negative Feed-Backs. In: Honda, Y., Miyamoto, Y., Konno, K., Widdicombe, J.G. (eds) Control of Breathing and Its Modeling Perspective. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-9847-0_69

Download citation

  • DOI: https://doi.org/10.1007/978-1-4757-9847-0_69

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4757-9849-4

  • Online ISBN: 978-1-4757-9847-0

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation