Skip to main content

Phosphoinositides and Signal Transduction in the Cat Carotid Body

  • Chapter

Abstract

The phosphoinositides, namely phosphatidylinositol-4,5-bisphosphate (PIP2) and phosphatidylinositol (PI) play an influential role in intracellular signaling. Phospholipase C (PLC) hydrolyzes PIP2 and PI to produce the signaling molecules inositol 1,4,5-trisphosphate (IP3) and diacylglycerol (DAG) which act to mobilize intracellular calcium and to stimulate protein phosphorylation, respectively.1 Quantifying PLC changes is thus one way to assess the phosphoinositide-dependent signal transduction process. We have previously reported that there are measurable amounts of PLC activity in the cat carotid body in the normoxic condition and that PLC activity is increased by hypoxia.2 Since activation of PLC may be part of the general mechanism by which the carotid body stimuli induce physiologic effects, we now extended that study by characterization of the effects on phosphoinositide metabolism of two further natural carotid body stimuli, respiratory and metabolic acidosis.

Keywords

  • Metabolic Acidosis
  • Carotid Body
  • Respiratory Acidosis
  • Signal Transduction Process
  • Phosphoinositide Metabolism

These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

This is a preview of subscription content, access via your institution.

Buying options

Chapter
USD   29.95
Price excludes VAT (USA)
  • DOI: 10.1007/978-1-4757-9847-0_65
  • Chapter length: 4 pages
  • Instant PDF download
  • Readable on all devices
  • Own it forever
  • Exclusive offer for individuals only
  • Tax calculation will be finalised during checkout
eBook
USD   129.00
Price excludes VAT (USA)
  • ISBN: 978-1-4757-9847-0
  • Instant PDF download
  • Readable on all devices
  • Own it forever
  • Exclusive offer for individuals only
  • Tax calculation will be finalised during checkout
Softcover Book
USD   169.99
Price excludes VAT (USA)
Hardcover Book
USD   249.99
Price excludes VAT (USA)

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. E. Meldrum, P.J. Parker, and A. Carozzi, The PtdIns-PLC superfamily and signal transduction, Biochim. Biophys. Acta 1092: 49 (1991).

    PubMed  CrossRef  CAS  Google Scholar 

  2. M. Pokorski and R. Strosznajder, PO2-dependence of phospholipase C in the cat carotid body, in: “Neurobiology and Cell Physiology,” P.G. Data, H. Acker, and S. Lahiri, ed., Plenum Press, London, (1992).

    Google Scholar 

  3. M. Pokorski and S. Lahiri, Aortic and carotid chemoreceptor responses to metabolic acidosis in the cat, Am. J. Physiol. 244:R652 (1983).

    PubMed  CAS  Google Scholar 

  4. P.S. Rodrigues and J.E. Dowling, Dopamine induces neurite retraction in retinal horizontal cells via diacylglycerol and protein kinase C, Proc. Natl. Acad. Sci. 87:9693 (1990).

    CrossRef  Google Scholar 

  5. A. Gomez-Nino, B. Dinger, C. Gonzalez, and S.J. Fidone, Differential stimulus coupling to dopamine and norepinephrine stores in rabbit carotid body type I cells, Brain Res. 525:160 (1990).

    PubMed  CrossRef  CAS  Google Scholar 

  6. R.H. Michell and C.J. Kirk, Studies of receptor-stimulated inositol lipid metabolism should focus upon measurements of inositol lipid breakdown, Biochem. J. 198:247 (1981).

    PubMed  CAS  Google Scholar 

  7. N. Okamura, Y. Tajima, S. Onoe, and Y. Sugita, Purification of bicarbonate-sensitive sperm adenylylcyclase by 4-acetamido-4′-isothiocyanostilbene-2,2′-disulfonic acid-affinity chromatography, J. Biol. Chem. 266:17754 (1991).

    PubMed  CAS  Google Scholar 

  8. W.J. Wang, G.F. Cheng, B.G. Dinger, and S.J. Fidone, Effects of hypoxia on cyclic nucleotide formation in rabbit carotid body in vitro, Neurosci. Lett. 105:164 (1989).

    PubMed  CrossRef  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and Permissions

Copyright information

© 1992 Springer Science+Business Media New York

About this chapter

Cite this chapter

Pokorski, M., Strosznajder, R. (1992). Phosphoinositides and Signal Transduction in the Cat Carotid Body. In: Honda, Y., Miyamoto, Y., Konno, K., Widdicombe, J.G. (eds) Control of Breathing and Its Modeling Perspective. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-9847-0_65

Download citation

  • DOI: https://doi.org/10.1007/978-1-4757-9847-0_65

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4757-9849-4

  • Online ISBN: 978-1-4757-9847-0

  • eBook Packages: Springer Book Archive