β-Endorphins-Based Inhibitory Component of the Mechanism of Ventilatory Response to Hypoxia
The hyperventilatory response to continuous hypoxic exposure in adult animals typically comprises an initial sharp rise of ventilation, a following precipitous fall to a lower level of hyperventilation (so-called “ventilatory depression”), and finally a gradual re-rising of ventilatory acclimatization. In contrast, the hypoxic ventilatory response in newborn animals and infants1, 2, 3 is predominantly hypoventilation instead of hyperventilation although an initial brief sharp rise of ventilation does appear as a rule.
KeywordsRespiratory Depression Ventilatory Response Hypoxic Exposure Inhibitory Component Hypoxic Ventilatory Response
Unable to display preview. Download preview PDF.
- 1.M.-C. Gong, S.-T. Hu, S.-Y. Huang and F.-D. Xu, Inhibitory component in the hyperventilatory response to acute hypoxia in adult rabbits and cats and evidence of participation of endorphins in the underlying mechanism, Acta Physiologica Sinica 37:107 (1985)Google Scholar
- 2.M.M. Grunstein, T.A. Harinski, and M.A. Schueter, Respiratory control during hypoxia in newborn rabbits: Implied action of endorphins, J. Appl. Physiol., Respirat., Environ., Exercise Physiol. 51:122 (1981)Google Scholar
- 3.J.P. Brady and E. Ceruti, Chemoreceptor reflexes in the newborn infant: Effect of varying degrees of hypoxia in a warm environment, J. Physiol. (Lond.) 184: 631 (1966)Google Scholar
- 4.D.-H. Huangfu, R.-Q. Huang, M.-C. Gong and S.-T. Hu, Central mechanism of hypoxia-induced respiratory depression, Chinese Journal of Physiological Sciences 6:166 (1990)Google Scholar
- 5.D.-H. Huangfu and S.-T. Hu, Changes of β-endorphins and monoamine transmitter metabolites in cat CSF during hypoxia, Chinese Journal of Physiological Sciences 6:201 (1990)Google Scholar
- 6.D.-H. Huangfu, T. Xu, H.-J. Du and S.-T. Hu, Response of neurons in the nucleus of solitary tract to transient deep hypoxia in rat medullary slices, Ibid 7: 34 (1991)Google Scholar
- 8.R.-Q. Huang, T. Xu and S.-T. Hu, Evidence for endorphin mediated analgesia induced by hypoxia in rabbits, Chinese Journal of Physiological Sciences 8:68 (1992)Google Scholar
- 9.T. Xu and S.-T. Hu, β-endorphins as basis of mechanism of hypoxic ventilatory inhibition, Ibid 8:95 (1992)Google Scholar
- 10.T. Xu and S.-T. Hu, Role of central monoamine in hypoxic ventilatory inhibition, Ibid 8:103(1992)Google Scholar
- 11.T. Xu and S.-T. Hu, Central localization of hypoxia-induced inhibitory effect of β-endorphin on ventilation in rabbits. Ibid (submitted)Google Scholar
- 12.R.-Q. Huang and S.-T. Hu, The role of nucleus parabrachialis in hypoxic respiratory inhibition in rabbits. Ibid (submitted)Google Scholar
- 13.F.E. Bloom, J. Rossier and E.L. Battenberg, β-endorphins: Cellular localization of electro-physiological and behavioral effects, in: “Advances in Biochemical Psychopharmacology,” E. Costa and M. Trabuchi ed., Raven Press, New YorkGoogle Scholar