Modulation of Respiration by Brain Hypoxia

  • J. A. Neubauer
  • J. E. Melton
  • Q. Yu
  • L. O. Chae
  • N. H. Edelman

Abstract

The dual nature of hypoxic modulation of central respiratory activity is best appreciated in the sino-aortic deafferented, anesthetized animal during progressive reductions in the arterial oxygen content.1 Figure 1 illustrates these two distinct central respiratory responses to brain hypoxia and their different oxygen thresholds; respiratory depression, which is manifested with even modest reductions in oxygenation, and respiratory excitation (gasping), which occurs only with severe reductions in the arterial oxygen content (to values less than 20%).

Keywords

Phrenic Nerve Severe Hypoxia Brain Hypoxia Neuronal Excitation Carotid Sinus Nerve 
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Copyright information

© Springer Science+Business Media New York 1992

Authors and Affiliations

  • J. A. Neubauer
    • 1
  • J. E. Melton
    • 1
  • Q. Yu
    • 1
  • L. O. Chae
    • 1
  • N. H. Edelman
    • 1
  1. 1.Division of Pulmonary and Critical Care Medicine, Department of Medicine, Robert Wood Johnson Medical SchoolUniversity of Medicine & Dentistry of New JerseyNew BrunswickUSA

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