Modulation of Respiration by Brain Hypoxia

  • J. A. Neubauer
  • J. E. Melton
  • Q. Yu
  • L. O. Chae
  • N. H. Edelman


The dual nature of hypoxic modulation of central respiratory activity is best appreciated in the sino-aortic deafferented, anesthetized animal during progressive reductions in the arterial oxygen content.1 Figure 1 illustrates these two distinct central respiratory responses to brain hypoxia and their different oxygen thresholds; respiratory depression, which is manifested with even modest reductions in oxygenation, and respiratory excitation (gasping), which occurs only with severe reductions in the arterial oxygen content (to values less than 20%).


Phrenic Nerve Severe Hypoxia Brain Hypoxia Neuronal Excitation Carotid Sinus Nerve 
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  1. 1.
    J.E. Melton, L. Oyer-Chae, J.A. Neubauer, and N.H. Edelman, Extracellular potassium homeostasis in the cat medulla during progressive brain hypoxia, J. Appl. Physiol. 70:1477 (1991).PubMedGoogle Scholar
  2. 2.
    Q.P. Yu, J.E. Melton, J.K-J. Li, J. A. Neubauer, and N.H. Edelman, The response of the phrenic neurogram to sinusoidal brain hypoxia, FASEB Journal 5:A665 (1991).Google Scholar
  3. 3.
    J.E. Melton, J.A. Neubauer, and N.H. Edelman, CO2 sensitivity of cat phrenic neurogram during hypoxic respiratory depression, J. Appl. Physiol. 65:736 (1988).PubMedGoogle Scholar
  4. 4.
    J.E. Melton, Q.P. Yu, J.A. Neubauer, and N.H. Edelman, Effect of brain hypoxia on peripheral chemoreception and respiratory afterdischarge in the cat, J. Appl. Physiol. (in press).Google Scholar
  5. 5.
    H.R. Winn, R. Rubio, and R.M. Berne, Brain adenosine concentration during hypoxia in rats, Am. J. Physiol. 241:H235 (1981).PubMedGoogle Scholar
  6. 6.
    M. Erecinska, D. Nelson, D.F. Wilson, and I.A. Silver, Neurotransmitter amino acids in the CNS. I. Regional changes in amino acid levels in rat brain during ischemia and reperfusion, Brain Res. 304:9 (1984).PubMedCrossRefGoogle Scholar
  7. 7.
    J.D. Wood, W.J. Watson, and A.J. Drucker, The effect of hypoxia on brain gamma-aminobutyric acid levels, J. Neurochem. 15:603 (1968).PubMedCrossRefGoogle Scholar
  8. 8.
    V. Chernick, and R.J. Craig, Naloxone reverses neonatal depression caused by fetal asphyxia, Science Wash. DC 216:1252 (1982).CrossRefGoogle Scholar
  9. 9.
    T.E. Duffy, S.R. Nelson, and O.H. Lowry, Cerebral carbohydrate metabolism during acute hypoxia and recovery, J. Neurochem. 19:959 (1972).PubMedCrossRefGoogle Scholar
  10. 10.
    J.A. Neubauer, A. Simone, and N.H. Edelman, Role of brain lactic acidosis in hypoxic depression of respiration, J. Appl. Physiol. 65:1324 (1988).PubMedGoogle Scholar
  11. 11.
    J.N. Davis, and A. Carlsson, Effect of hypoxia on monoamine synthesis, levels and metabolism in rat brain, J. Neurochem. 21:783 (1973).PubMedCrossRefGoogle Scholar
  12. 12.
    G.E. Gibson, M. Shimada, and J.P. Blass, Alterations in acetylcholine synthesis and in cyclic nucleotides in mild cerebral hypoxia, J. Neurochem. 31:757 (1978).PubMedCrossRefGoogle Scholar
  13. 13.
    J.A. Neubauer, M.A. Posner, T.V. Santiago, and N.H. Edelman, Naloxone reduces ventilatory depression of brain hypoxia, J. Appl. Physiol. 63:699 (1987).PubMedGoogle Scholar
  14. 14.
    F.P. Nissley, J.E. Melton, J.A. Neubauer, and N.H. Edelman, Effect of adenosine antagonism on phrenic nerve output during brain hypoxia, Fed. Proc. 45:1046 (1986).Google Scholar
  15. 15.
    J.E. Melton, J.A. Neubauer, and N.H. Edelman, GABA antagonism reverses hypoxic respiratory depression in the cat, J.Appl. Physiol. 69:1296 (1990).PubMedGoogle Scholar
  16. 16.
    M.J. Wasicko, J.E. Melton, J.A. Neubauer, N. Krawciw, and N.H. Edelman, Cervical sympathetic and phrenic nerve responses to progressive brain hypoxia, J. Appl. Physiol. 68:53 (1990).PubMedGoogle Scholar
  17. 17.
    L. Oyer-Chae, J.E. Melton, J.A. Neubauer, and N.H. Edelman, Differential phrenic (PN) and sympathetic nerve responses to an NMDA blocker in progressive brain hypoxia (PBH). FASEB Journal 4:A405 (1990).Google Scholar
  18. 18.
    L. Oyer-Chae, J.E. Melton, J.A. Neubauer, and N.H. Edelman, Non-NMDA blockade alters eupneic but not hypoxia-induced gasping activity of the phrenic nerve, FASEB Journal 5: A664 (1991).Google Scholar
  19. 19.
    M.S. Jacobi, and B.T. Thach, Effect of maturation on spontaneous recovery from hypoxic apnea by gasping, J. Appl. Physiol. 66:2384 (1989).PubMedGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1992

Authors and Affiliations

  • J. A. Neubauer
    • 1
  • J. E. Melton
    • 1
  • Q. Yu
    • 1
  • L. O. Chae
    • 1
  • N. H. Edelman
    • 1
  1. 1.Division of Pulmonary and Critical Care Medicine, Department of Medicine, Robert Wood Johnson Medical SchoolUniversity of Medicine & Dentistry of New JerseyNew BrunswickUSA

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