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Control of Breathing and Its Modeling Perspective pp 237–243Cite as

Dynamic Asymmetries of Ventilation and Pulmonary Gas Exchange during On- and Off-Transients of Heavy Exercise in Humans

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Abstract

Inferences for the physiological control mechanisms which couple: (a) tissue O2 and CO2 exchange to muscular force generation and also (b) pulmonary gas exchange to tissue gas exchange may be drawn from a precise breath-by-breath characterization of the ventilatory and pulmonary gas exchange response transients to appropriately-selected work-rate (W) forcings.1, 2, 3 As the components of these characterizations, in terms of delays (δ), time constants (τ) and gains (G), reflect the underlying physiological processes, this allows a physiological control model to be assembled. However, mathematical features of the model (i. e., the ‘what’ of parametrization) need to have as their frame of reference known, or hypothesized, physiological structures involved in the putative control scheme (i. e., the’ so what’ of model formulation).

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References

  1. B.J. Whipp and S.A. Ward, Physiological determinants of pulmonary gas exchange kinetics during exercise, Med. Sei. Sports Ex. 22:62 (1990).

    CAS  Google Scholar 

  2. T.J. Barstow, N. Lamarra, and B.J. Whipp, Modulation of muscle and pulmonary O2 uptakes by circulatory dynamics during exercise, J. Appl. Physiol. 68:979 (1990).

    Article  PubMed  CAS  Google Scholar 

  3. D. Linnarsson, Dynamics of pulmonary gas exchange and heart rate changes at start and end of exercise, Acta Physiol. Scand. (suppl.) 415:1 (1974).

    CAS  Google Scholar 

  4. R.L. Hughson, Exploring cardiorespiratory control mechanisms through gas exchange dynamics, Med. Sci. Sports Ex. 22:72 (1990).

    CAS  Google Scholar 

  5. B.J. Whipp and M. Mahler, Dynamics of gas exchange during exercise, in: “Pulmonary Gas Exchange” Vol. II, J.B. West, ed., Academic Press, New York (1980).

    Google Scholar 

  6. W.L. Roston, B.J. Whipp, J.A. Davis, D.A. Cunningham, R.M. Effros, and K. Wasserman, Oxygen uptake kinetics and lactate concentration during exercise in humans, Am. Rev. Respir. Dis. 135:1080 (1987).

    PubMed  CAS  Google Scholar 

  7. D.C. Poole, S. A. Ward, G.W. Gardner, and B.J. Whipp, Metabolic and respiratory profile of the upper limit for prolonged exercise in man, Ergonomics 31:1265(1988).

    Article  PubMed  CAS  Google Scholar 

  8. R. Casaburi, T.W. Storer, I. Ben Dov, and K. Wasserman, Effect of endurance training on possible determinants of V-̇O2 during heavy exercise, J. Appl. Physiol. 62: 199 (1987).

    PubMed  CAS  Google Scholar 

  9. B.J. Whipp, J.A. Davis, F. Torres, and K. Wasserman, A test to determine the parameters of aerobic function during exercise, J. Appl. Physiol. 50:217(1981).

    PubMed  CAS  Google Scholar 

  10. G.D. Swanson and R.L. Hughson, On the modelling and interpretation of oxygen uptake kinetics from ramp work rate tests, J. Appl. Physiol. 65:2453 (1988).

    PubMed  CAS  Google Scholar 

  11. T. Yoshida, Gas exchange responses to ramp exercise, Ann. Physiol. Anthrop. 9:167(1990).

    Article  CAS  Google Scholar 

  12. D.H. Paterson and B.J. Whipp, Asymmetries of oxygen uptake transients at the on-and off-set ofheavy exercise in humans, J.Physiol. (Lond.). 443:575(1991).

    CAS  Google Scholar 

  13. G.A. Gaesser, S.A. Ward, V.C. Baum, and B.J. Whipp, The effects of infused epinephrine on the “excess” 02 uptake of heavy exercise in humans, Fed. Proc. April (1992).

    Google Scholar 

  14. D.A. Roth, W.C. Stanley, and G.A. Brooks, Induced lactacidemia does not affect post-exercise O2 consumption, J. Appl. Physiol. 65:1045 (1988).

    PubMed  CAS  Google Scholar 

  15. J.M. Krisanda, T.S. Moreland, and M.J. Kushmerik, ATP supply and demand during exercise, in: “Exercise, Nutrition, and Energy Metabolism,” E.S. Horton and R.L. Terjung, MacMillan, New York (1988).

    Google Scholar 

  16. P.G. Schantz and J. Henriksson, Enzyme levels of the NADH shuttle systems: measurements in isolated muscle fibers from humans of differing physical activity, Acta Physiol. Scand. 129:505 (1987).

    Article  PubMed  CAS  Google Scholar 

  17. T.J. Barstow and P.J. Molé, Linear and nonlinear characteristics of oxygen uptake kinetics during heavy exercise, J. Appl. Physiol. 71:2099 (1991).

    PubMed  CAS  Google Scholar 

  18. J.E. Hansen, R. Casaburi, D.M. Cooper and K. Wasserman, Oxygen uptake as related to work rate increment during cycle ergometer exercise, Europ. J. Appl. Physiol 57:140(1988).

    Article  CAS  Google Scholar 

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Author information

Authors and Affiliations

  1. Department of Physiology, UCLA, Los Angeles, CA, 90024, USA

    Brian J. Whipp

  2. Department of Anesthesiology, UCLA, Los Angeles, CA, 90024, USA

    Susan A. Ward

  3. Department of Physical Education, University of Western Ontario, Canada

    D. A. Paterson

Authors
  1. Brian J. Whipp
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  2. Susan A. Ward
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  3. D. A. Paterson
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Editor information

Editors and Affiliations

  1. Chiba University, Chiba, Japan

    Yoshiyuki Honda

  2. Yamagata University, Yonezawa, Japan

    Yoshimi Miyamoto

  3. Tokyo Women’s Medical College, Tokyo, Japan

    Kimio Konno

  4. St. George’s Hospital Medical School, London, UK

    John G. Widdicombe

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© 1992 Springer Science+Business Media New York

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Whipp, B.J., Ward, S.A., Paterson, D.A. (1992). Dynamic Asymmetries of Ventilation and Pulmonary Gas Exchange during On- and Off-Transients of Heavy Exercise in Humans. In: Honda, Y., Miyamoto, Y., Konno, K., Widdicombe, J.G. (eds) Control of Breathing and Its Modeling Perspective. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-9847-0_41

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  • DOI: https://doi.org/10.1007/978-1-4757-9847-0_41

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4757-9849-4

  • Online ISBN: 978-1-4757-9847-0

  • eBook Packages: Springer Book Archive

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