Dynamic Asymmetries of Ventilation and Pulmonary Gas Exchange during On- and Off-Transients of Heavy Exercise in Humans

  • Brian J. Whipp
  • Susan A. Ward
  • D. A. Paterson


Inferences for the physiological control mechanisms which couple: (a) tissue O2 and CO2 exchange to muscular force generation and also (b) pulmonary gas exchange to tissue gas exchange may be drawn from a precise breath-by-breath characterization of the ventilatory and pulmonary gas exchange response transients to appropriately-selected work-rate (W) forcings.1, 2, 3 As the components of these characterizations, in terms of delays (δ), time constants (τ) and gains (G), reflect the underlying physiological processes, this allows a physiological control model to be assembled. However, mathematical features of the model (i. e., the ‘what’ of parametrization) need to have as their frame of reference known, or hypothesized, physiological structures involved in the putative control scheme (i. e., the’ so what’ of model formulation).


Work Rate Lactate Threshold Heavy Exercise Glycogen Resynthesis Oxygen Uptake Kinetic 
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Copyright information

© Springer Science+Business Media New York 1992

Authors and Affiliations

  • Brian J. Whipp
    • 1
  • Susan A. Ward
    • 2
  • D. A. Paterson
    • 3
  1. 1.Department of PhysiologyUCLALos AngelesUSA
  2. 2.Department of AnesthesiologyUCLALos AngelesUSA
  3. 3.Department of Physical EducationUniversity of Western OntarioCanada

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