Effects of Testosterone on Hypoxic Ventilatory and Carotid Body Neural Responsiveness
Hypoxic ventilatory response (HVR) is known to be influenced by administration of testosterone but prior studies report conflicting results1, 2. White et al.1 reported an augmented HVR after testosterone replacement in hypogonadal males, whereas Matsumoto et al.2 found HVR decreased after testosterone treatment. In addition, the site at which the hormone acts remains unclear. No studies have been undertaken to determine whether testosterone alters carotid body neural responsiveness to hypoxia and, if so, whether it acts directly on the peripheral chemoreceptors and/or on the central nervous system translation of carotid sinus nerve (CSN) output into ventilation.
KeywordsCarotid Body Anesthetize Animal Testosterone Replacement Testosterone Treatment Peripheral Chemoreceptor
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