Does Sustained Hypoxia Have Biphasic Effects on the Sensation of Dyspnea?

  • Tatsuya Chonan
  • Wataru Hida
  • Shinichi Okabe
  • Yeontae Chung
  • Yoshihiro Kikuchi
  • Tamotsu Takishima

Abstract

The effect of sustained hypoxia on respiration is reported to be biphasic and comprised of an initial stimulatory phase mediated by peripheral chemoreceptors and a following depressive phase caused by central mechanisms (Neubauer, 1990). However, it is not clear how sustained hypoxia affects respiratory sensations. In this study we wished to ascertain whether sustained hypoxia has a biphasic effects on the sensation of dyspnea as well as on ventilation.

Keywords

Minute Ventilation Hypoxic Exposure Biphasic Effect Peripheral Chemoreceptor Mouth Pressure 
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Copyright information

© Springer Science+Business Media New York 1992

Authors and Affiliations

  • Tatsuya Chonan
    • 1
  • Wataru Hida
    • 1
  • Shinichi Okabe
    • 1
  • Yeontae Chung
    • 1
  • Yoshihiro Kikuchi
    • 1
  • Tamotsu Takishima
    • 1
  1. 1.First Department of Internal MedicineTohoku University School of MedicineSendaiJapan

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