Abstract
The effect of sustained hypoxia on respiration is reported to be biphasic and comprised of an initial stimulatory phase mediated by peripheral chemoreceptors and a following depressive phase caused by central mechanisms (Neubauer, 1990). However, it is not clear how sustained hypoxia affects respiratory sensations. In this study we wished to ascertain whether sustained hypoxia has a biphasic effects on the sensation of dyspnea as well as on ventilation.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsPreview
Unable to display preview. Download preview PDF.
References
Cherniack, N.S., 1986, Potential role of optimization in alveolar hypoventilation and respiratory instability, in: “Neurobiology of the Control of Breathing, “C von. Euler and H. Lagercrants, eds., Raven Press, New York.
Chonan, T., Mulholland, M.B., Leitner, J., Altose, M.D., and Cherniack, N.S., 1990, Sensation of dyspnea during hypercapnia, exercise, and voluntary hyperventilation, J Appl Physiol. 68: 2100.
Chonan, T., Altose, M.D., and Cherniack, N.S., 1990, Effects of expiratory resistive loading on the sensationof dyspnea, J Appl Physiol. 69: 91.
Chonan, T., Mulholland, M.B., Altose, M.D., and Cherniack, N.S., 1990, Effects of changes in level and pattern of breathing of on the sensation of dyspnea, J Appl Physiol. 69:1290.
Killian, K.J., Gandevia, S.C, Summers, E., and Campbell, E.J.M., 1984, Effect of increased lung volume on perception of breathlessness, effort and tension, J Appl Physiol. 57: 686.
Neubauer, J.A., Melton, J.E., and Edelman, N.H., 1990, Modulation of respiration during brain hypoxia, J Appl Physiol. 68:441.
Ward, S.A., and Whipp, B.J., 1989, Effects of peripheral and central chemoreflex activation on the isopnoeic rating of breathig in exercising humans, J Physiol [London]. 411:27.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1992 Springer Science+Business Media New York
About this chapter
Cite this chapter
Chonan, T., Hida, W., Okabe, S., Chung, Y., Kikuchi, Y., Takishima, T. (1992). Does Sustained Hypoxia Have Biphasic Effects on the Sensation of Dyspnea?. In: Honda, Y., Miyamoto, Y., Konno, K., Widdicombe, J.G. (eds) Control of Breathing and Its Modeling Perspective. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-9847-0_33
Download citation
DOI: https://doi.org/10.1007/978-1-4757-9847-0_33
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4757-9849-4
Online ISBN: 978-1-4757-9847-0
eBook Packages: Springer Book Archive