Redundancy Structures in Respiratory Control

  • George D. Swanson


The observation that arterial CO2 tension is regulated (remains at the resting value) under a metabolic CO2 load via exercise, but increases under an airway CO2 load via inspiratory CO2, has motivated numerous theories about the structure of the respiratory controller. This respiratory control system behavior appears to be most consistent with a feedforward/feedback control system structure.1 The peripheral chemoreceptors (carotid body) and indirectly central brain chemoreceptors act as feedback mechanisms with respect to the regulation of arterial CO2 tension. Feedforward mechanisms (signals related to metabolic CO2 production during exercise) are more controversial. Part of this controversy relates to the traditional “search” for a “single” mechanism that will explain the exercise hyperpnea response.2 However, in general, biological systems are characterized by redundancy, suggesting that many “signals” may be combined to form an appropriate feedforward stimulus.


Carotid Body Optimal Controller Peripheral Chemoreceptor Redundancy Structure Carotid Sinus Nerve 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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  1. 1.
    G. D. Swanson, Overview of ventilating control during exercise, Med. Sci. Sports 11: 221–226 (1979).PubMedGoogle Scholar
  2. 2.
    J. H. Comroe, Physiology of Respiration, Year Book Medical Chicago (1974).Google Scholar
  3. 3.
    G. D. Swanson, “Respiratory control during exercise,” in Encyclopedia of Systems and Control, M. Singh, Ed. Oxford: Pergamon, pp. 4045–4051 (1988).Google Scholar
  4. 4.
    W. S. Yamamoto, Computer simulation of ventilatory control by both neural and humoral CO2 signals. Am. 7. Physiol. 238: 28–35 (1980).Google Scholar
  5. 5.
    E. Neil, R. G. O’Regan, The effects of electrical stimulation of the distal and the cut sinus and aortic nerves on peripheral arterial chemoreception activity in the cat. J. Physiol. 215: 15–32 (1971).PubMedGoogle Scholar
  6. 6.
    E. Neil, R. G. O’Regan, Efferent and afferent impulse activity recorded from few-fibre preparations of outher intact sinus and aortic nerves. J. Physiol. 215: 33–47 (1971).PubMedGoogle Scholar
  7. 7.
    R. Lugliani, B. J. Whipp, C. Seard, K. Wasserman, Effects of bilateral carotid body resection on ventilatory control at rest and during exercise in man. N. Eng. J. Med., 285: 1105–1111 (1971).CrossRefGoogle Scholar
  8. 8.
    C.S. Poon, Optimal Control of ventilation in hypoxia, hypercapnia and exercise. In: B. J. Whipp, D. M. Wiberg (eds.) Proc. Symp. Modelling and Control of Breathing. Elsevier, Amsterdam, pp. 189–196 (1983).Google Scholar
  9. 9.
    G. D. Swanson and P. A. Robbins, Optimal respiratory controller structures, IEEE Trans. Biomed Engr. 33: 677–680 (1986).CrossRefGoogle Scholar
  10. 10.
    G. D. Swanson, Reply to comments on “Optimal respiratory controller structures.” IEEE Trans. Biomed. Engr. 35-395-397 (1988).Google Scholar
  11. 11.
    G. C. Moore, C. W. Zwillich, J. D. Battaglia, E. K. Cotton, and J. V. Weill, “Respiratory failure associated with familial depression of ventilatory response of hypoxia and hypercapnia,” New England, J. Med., vol. 295, pp. 862–865 (1976).Google Scholar
  12. 12.
    S. A. Shea, L. P. Andres, R. B. Banzett, A. Guz and D. C. Shannon, The ventilatory response to exercise in the absence of CO2 sensitivity, Am. Rev. Respir, Dis. 143: A593 (1991).CrossRefGoogle Scholar
  13. 13.
    S. A. Ward and B. J. Whipp, “Ventilatory control during exercise with increased external dead space,” J. Appl. Physiol. vol. 48, pp. 225–231 (1980).PubMedGoogle Scholar
  14. 14.
    G. D. Swanson, The exercise hyperpnea dilemma, Chest 73: 270–272 (1978).Google Scholar
  15. 15.
    W. W. Harmon, “A re-examination of the metaphysical foundations of modern science,” The Institute of Noctic Sciences, Sausalito, California (1991).Google Scholar
  16. 16.
    Yogi Ramachavaka, “A Science of Breath,” The Yogi Publication Society, Chicago (1905).Google Scholar

Copyright information

© Springer Science+Business Media New York 1992

Authors and Affiliations

  • George D. Swanson
    • 1
  1. 1.Department of Physical Education and Pacific Wellness InstituteCalifornia State UniversityChicoUSA

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